CRCGN008_HEPG2_24H:H12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tiabendazole 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN008_HEPG2_24H:H12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SQOR sulfide quinone oxidoreductase 5.64335
E2F2 E2F transcription factor 2 5.33725
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.1486
HLA-DMA major histocompatibility complex, class II, DM alpha 5.12765
DYNLT3 dynein, light chain, Tctex-type 3 4.9227
CBR3 carbonyl reductase 3 4.85335
C2CD2 C2 calcium-dependent domain containing 2 4.5959
ATP11B ATPase, class VI, type 11B 4.5437
PEX11A peroxisomal biogenesis factor 11 alpha 4.28527
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.9918
CBR1 carbonyl reductase 1 3.65465
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.6362
LPAR2 lysophosphatidic acid receptor 2 3.55507
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.50623
PRR15L proline rich 15-like 3.47875
SH3D19 SH3 domain containing 19 3.4371
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.4074
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.20305
CDPF1 cysteine-rich, DPF motif domain containing 1 3.16445
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.1616
CHN1 chimerin 1 3.1502
MAP7 microtubule-associated protein 7 2.98375
HLA-DRA major histocompatibility complex, class II, DR alpha 2.9628
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.8401
SSBP2 single-stranded DNA binding protein 2 2.71725
CYCS cytochrome c, somatic 2.52695
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.5093
SCRN1 secernin 1 2.501
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.49605
PDE5A phosphodiesterase 5A, cGMP-specific 2.41175
LRRC61 leucine rich repeat containing 61 2.37905
CAMKMT calmodulin-lysine N-methyltransferase 2.36675
DMTF1 cyclin D binding myb-like transcription factor 1 2.35825
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.26345
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 2.1851
SPRY4 sprouty homolog 4 (Drosophila) 2.17535
CLIC3 chloride intracellular channel 3 2.08845
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.06362
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.0489

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.1905
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.8302
ZNF586 zinc finger protein 586 -4.5303
FASTKD5 FAST kinase domains 5 -4.34815
TMEM109 transmembrane protein 109 -4.24795
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.24205
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.78815
WASHC4 WASH complex subunit 4 -3.31255
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.26028
TCTN1 tectonic family member 1 -3.0652
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.04655
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.90595
TOMM70 translocase of outer mitochondrial membrane 70 -2.88505
FBXL12 F-box and leucine-rich repeat protein 12 -2.84655
MTA1 metastasis associated 1 -2.79283
CDC25B cell division cycle 25B -2.74555
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.72502
HMG20B high mobility group 20B -2.69102
PGM1 phosphoglucomutase 1 -2.6744
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -2.2833
ZW10 zw10 kinetochore protein -2.22055
DENND4C DENN/MADD domain containing 4C -2.2059
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.1935
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.15095
AHCYL1 adenosylhomocysteinase-like 1 -2.0778