CRCGN008_HEPG2_24H:H13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(ethylsulfanyl)butanoic acid 21.44 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN008_HEPG2_24H:H13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.0848
PRR15L proline rich 15-like 8.106
ADRB2 adrenoceptor beta 2, surface 5.8058
CCL2 chemokine (C-C motif) ligand 2 5.5091
STK10 serine/threonine kinase 10 5.10437
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9813
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.9151
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.74155
CD40 CD40 molecule, TNF receptor superfamily member 5 4.32498
NMU neuromedin U 4.11715
ZFP36 ZFP36 ring finger protein 4.06175
EGF epidermal growth factor 3.78205
PLSCR1 phospholipid scramblase 1 3.69052
LOC122526780 uncharacterized LOC122526780 3.4671
PFKL phosphofructokinase, liver 3.34182
CYCS cytochrome c, somatic 3.3397
NPDC1 neural proliferation, differentiation and control, 1 3.13995
ANO1 anoctamin 1, calcium activated chloride channel 2.9647
ISG15 ISG15 ubiquitin-like modifier 2.8723
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.76507
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.76005
CORO1A coronin, actin binding protein, 1A 2.74205
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.7286
MX1 MX dynamin-like GTPase 1 2.72545
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.71725
GATA2 GATA binding protein 2 2.70548
IFI44L interferon-induced protein 44-like 2.69535
SYT17 synaptotagmin XVII 2.5312
IFI44 interferon-induced protein 44 2.48735
H2BC12 H2B clustered histone 12 2.47062
VEGFD vascular endothelial growth factor D 2.46285
AAMP angio-associated, migratory cell protein 2.45345
COX17 COX17 cytochrome c oxidase copper chaperone 2.3545
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.3145
BZW2 basic leucine zipper and W2 domains 2 2.24545
METTL1 methyltransferase like 1 2.239
APP amyloid beta (A4) precursor protein 2.22735
TM4SF5 transmembrane 4 L six family member 5 2.22085
ADAP2 ArfGAP with dual PH domains 2 2.2045
LY6H lymphocyte antigen 6 complex, locus H 2.18585
CENPM centromere protein M 2.18505
PCNT pericentrin 2.1774
MCMBP minichromosome maintenance complex binding protein 2.16855
DAAM1 dishevelled associated activator of morphogenesis 1 2.1677
USP18 ubiquitin specific peptidase 18 2.1233
EHD4 EH-domain containing 4 2.1108
UBE2E1 ubiquitin-conjugating enzyme E2E 1 2.10305
IFI6 interferon, alpha-inducible protein 6 2.0913
CCL19 chemokine (C-C motif) ligand 19 2.05885
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.05264
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.03925

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.96805
LDHD lactate dehydrogenase D -5.0035
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.89515
NT5DC2 5'-nucleotidase domain containing 2 -4.8292
PCNA proliferating cell nuclear antigen -4.77245
ADI1 acireductone dioxygenase 1 -4.7303
THAP11 THAP domain containing 11 -4.5284
HLA-DMA major histocompatibility complex, class II, DM alpha -4.44135
ZNF586 zinc finger protein 586 -4.31785
CCNB2 cyclin B2 -3.93715
WASHC4 WASH complex subunit 4 -3.80493
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.7463
FBXL12 F-box and leucine-rich repeat protein 12 -3.5478
ARID5B AT rich interactive domain 5B (MRF1-like) -3.5348
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.5134
S100A4 S100 calcium binding protein A4 -3.31215
RGS2 regulator of G-protein signaling 2 -3.3042
ACAA1 acetyl-CoA acyltransferase 1 -3.16277
HSPA8 heat shock 70kDa protein 8 -3.09658
MAP7 microtubule-associated protein 7 -2.99902
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.7508
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.46765
ACLY ATP citrate lyase -2.41875
CDC25B cell division cycle 25B -2.36845
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.36625
ANGPTL7 angiopoietin-like 7 -2.30955
ITGB1BP1 integrin beta 1 binding protein 1 -2.30568
ERCC6 excision repair cross-complementation group 6 -2.2226
HAUS4 HAUS augmin-like complex, subunit 4 -2.2182
LAPTM4A lysosomal protein transmembrane 4 alpha -2.13815