CRCGN008_HEPG2_24H:H14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(ethylsulfanyl)butanoic acid 10.72 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

169 genes differentially expressed following the CRCGN008_HEPG2_24H:H14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 10.0
CHN1 chimerin 1 6.4946
CYCS cytochrome c, somatic 6.34635
STK10 serine/threonine kinase 10 5.80443
LCN2 lipocalin 2 5.7578
DYNLT3 dynein, light chain, Tctex-type 3 5.66485
NOTCH1 notch 1 5.3048
CBR3 carbonyl reductase 3 5.2606
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.19945
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.16895
GSTZ1 glutathione S-transferase zeta 1 4.96525
MYLK myosin light chain kinase 4.783
AMDHD2 amidohydrolase domain containing 2 4.6698
UBQLN2 ubiquilin 2 4.6391
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.55568
CDPF1 cysteine-rich, DPF motif domain containing 1 4.51185
SNAP25 synaptosomal-associated protein, 25kDa 4.13395
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.10618
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.9772
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.86845
SOCS2 suppressor of cytokine signaling 2 3.4416
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.25524
EVL Enah/Vasp-like 3.19165
JADE2 jade family PHD finger 2 3.15815
CTSL cathepsin L 3.1436
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 3.08265
MCM3 minichromosome maintenance complex component 3 3.08095
TIAM1 T-cell lymphoma invasion and metastasis 1 3.02325
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.9733
GPATCH8 G patch domain containing 8 2.94607
SSBP2 single-stranded DNA binding protein 2 2.7338
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.694
SELPLG selectin P ligand 2.65313
TMEM35B transmembrane protein 35B 2.64885
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.6363
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.60275
RPL18 ribosomal protein L18 2.58035
LPAR2 lysophosphatidic acid receptor 2 2.56348
PLSCR1 phospholipid scramblase 1 2.54855
ITM2C integral membrane protein 2C 2.50315
PTPRK protein tyrosine phosphatase, receptor type, K 2.4883
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.41545
ZBTB35 zinc finger and BTB domain containing 35 2.35895
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.34435
ISG15 ISG15 ubiquitin-like modifier 2.3346
IFI44L interferon-induced protein 44-like 2.32105
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.27565
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.2736
TOR1B torsin family 1, member B (torsin B) 2.25115
CCNF cyclin F 2.22005
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.21285
USP11 ubiquitin specific peptidase 11 2.2025
YJU2 YJU2 splicing factor homolog 2.1779
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 2.1578
SELL selectin L 2.1566
FIP1L1 factor interacting with PAPOLA and CPSF1 2.15495
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.1521
ITK IL2-inducible T-cell kinase 2.1461
EMP3 epithelial membrane protein 3 2.14375
SNX10 sorting nexin 10 2.12035
CD99 CD99 molecule 2.11125
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.10955
OCEL1 occludin/ELL domain containing 1 2.0926
ICAM2 intercellular adhesion molecule 2 2.0773
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.07095
STRADA STE20-related kinase adaptor alpha 2.06542
NAP1L2 nucleosome assembly protein 1-like 2 2.06435
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.0563
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.0545
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.05205
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.0439
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2.04365
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.04015
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.0339
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.0285
GSTT1 glutathione S-transferase theta 1 2.02745
GOLGA8F golgin A8 family, member F 2.02285
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.02225
CTPS1 CTP synthase 1 2.02135
PTK2 protein tyrosine kinase 2 2.0115
EIF4A3 eukaryotic translation initiation factor 4A3 2.0088

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.94945
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.75275
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.25325
ZNF586 zinc finger protein 586 -5.09785
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.99855
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.9834
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.83655
ADI1 acireductone dioxygenase 1 -4.6102
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.4745
CCNB1 cyclin B1 -4.09615
TOMM70 translocase of outer mitochondrial membrane 70 -3.94402
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.6586
LYPLA1 lysophospholipase I -3.5443
FOS FBJ murine osteosarcoma viral oncogene homolog -3.5334
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.49245
RGS2 regulator of G-protein signaling 2 -3.42785
YME1L1 YME1-like 1 ATPase -3.30335
OXA1L oxidase (cytochrome c) assembly 1-like -3.24045
HSPA8 heat shock 70kDa protein 8 -3.05773
NVL nuclear VCP-like -3.0082
GREB1L growth regulation by estrogen in breast cancer-like -2.9588
CAB39 calcium binding protein 39 -2.80395
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.7439
CLIC4 chloride intracellular channel 4 -2.70407
ST7L suppression of tumorigenicity 7 like -2.6851
NRIP1 nuclear receptor interacting protein 1 -2.62348
NMD3 NMD3 ribosome export adaptor -2.61695
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.613
FBXL12 F-box and leucine-rich repeat protein 12 -2.5691
PRPF4 pre-mRNA processing factor 4 -2.5583
CYB5A cytochrome b5 type A (microsomal) -2.53935
TENT4A terminal nucleotidyltransferase 4A -2.5338
MITF microphthalmia-associated transcription factor -2.4968
CD58 CD58 molecule -2.48597
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.4391
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -2.4311
RGS18 regulator of G-protein signaling 18 -2.42715
ALS2CL ALS2 C-terminal like -2.3535
RABL6 RAB, member RAS oncogene family-like 6 -2.3455
IRS4 insulin receptor substrate 4 -2.3148
TM9SF3 transmembrane 9 superfamily member 3 -2.30705
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) -2.305
ZNF175 zinc finger protein 175 -2.29265
TMEM186 transmembrane protein 186 -2.28815
RAB11FIP3 RAB11 family interacting protein 3 (class II) -2.27848
PEAK1 pseudopodium-enriched atypical kinase 1 -2.2338
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -2.21793
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 -2.18845
ELL3 elongation factor RNA polymerase II-like 3 -2.18068
TXNDC9 thioredoxin domain containing 9 -2.17957
RAB36 RAB36, member RAS oncogene family -2.17315
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.16695
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.1639
ZNF324 zinc finger protein 324 -2.1637
TFDP3 transcription factor Dp family, member 3 -2.15765
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.15565
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.1501
ANKRD26 ankyrin repeat domain 26 -2.14707
TNS4 tensin 4 -2.14485
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -2.1441
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 -2.14245
SYT17 synaptotagmin XVII -2.1309
THEM6 thioesterase superfamily member 6 -2.12785
PRAMEF26 PRAME family member 26 -2.1163
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.1121
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit -2.1088
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A -2.10853
TSKU tsukushi, small leucine rich proteoglycan -2.0976
SH2D3C SH2 domain containing 3C -2.09755
NIPAL2 NIPA-like domain containing 2 -2.0939
CLTB clathrin, light chain B -2.09025
IFT22 intraflagellar transport 22 -2.0796
NMI N-myc (and STAT) interactor -2.0762
FSTL1 follistatin-like 1 -2.07145
NIT2 nitrilase family, member 2 -2.0673
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -2.06315
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -2.0547
GJA1 gap junction protein, alpha 1, 43kDa -2.0417
NAV2 neuron navigator 2 -2.0415
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.033
CLUH clustered mitochondria (cluA/CLU1) homolog -2.03085
ANK1 ankyrin 1, erythrocytic -2.02603
GAR1 GAR1 ribonucleoprotein -2.02275
PLEKHA6 pleckstrin homology domain containing, family A member 6 -2.0227
WNT5A wingless-type MMTV integration site family, member 5A -2.02213
FMNL3 formin-like 3 -2.0202
SH2D4A SH2 domain containing 4A -2.0079