| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (2s)-2-amino-4-(ethylsulfanyl)butanoic acid 0.67 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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160 genes differentially expressed following the CRCGN008_HEPG2_24H:H18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 10.0 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 10.0 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 9.34955 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 6.53512 |
| ADRB2 | adrenoceptor beta 2, surface | 6.31155 |
| FCHO1 | FCH domain only 1 | 6.1148 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 5.84495 |
| RPL39L | ribosomal protein L39-like | 5.75745 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.08485 |
| MSRA | methionine sulfoxide reductase A | 4.8058 |
| MYLK | myosin light chain kinase | 4.52935 |
| NOSIP | nitric oxide synthase interacting protein | 4.4915 |
| PRKCD | protein kinase C, delta | 4.4711 |
| CBR3 | carbonyl reductase 3 | 4.36035 |
| EGF | epidermal growth factor | 3.96595 |
| FZD7 | frizzled class receptor 7 | 3.83273 |
| TAC4 | tachykinin 4 (hemokinin) | 3.7724 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.68815 |
| JADE2 | jade family PHD finger 2 | 3.686 |
| PRR15L | proline rich 15-like | 3.61175 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.5546 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.54738 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 3.52065 |
| ABHD6 | abhydrolase domain containing 6 | 3.4973 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 3.42918 |
| PLSCR1 | phospholipid scramblase 1 | 3.38828 |
| KLHL9 | kelch-like family member 9 | 3.26285 |
| CCDC85B | coiled-coil domain containing 85B | 3.1901 |
| MMP1 | matrix metallopeptidase 1 | 3.17173 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 3.0459 |
| CLDN10 | claudin 10 | 2.93595 |
| TBC1D31 | TBC1 domain family, member 31 | 2.8442 |
| RRAGA | Ras-related GTP binding A | 2.79625 |
| IL17RB | interleukin 17 receptor B | 2.698 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 2.6893 |
| CHN1 | chimerin 1 | 2.5197 |
| ARMCX5-GPRASP2 | ARMCX5-GPRASP2 readthrough | 2.43825 |
| CHKB | choline kinase beta | 2.4345 |
| STX1A | syntaxin 1A (brain) | 2.4247 |
| EPHA3 | EPH receptor A3 | 2.41632 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 2.395 |
| TMEM135 | transmembrane protein 135 | 2.38405 |
| OMD | osteomodulin | 2.36943 |
| BLNK | B-cell linker | 2.3373 |
| EVL | Enah/Vasp-like | 2.29755 |
| UNC93B1 | unc-93 homolog B1 (C. elegans) | 2.2948 |
| SIRT3 | sirtuin 3 | 2.29275 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | 2.29115 |
| ZNF589 | zinc finger protein 589 | 2.28533 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | 2.28513 |
| ZNF239 | zinc finger protein 239 | 2.28025 |
| SOX12 | SRY (sex determining region Y)-box 12 | 2.25785 |
| MMP13 | matrix metallopeptidase 13 | 2.2269 |
| TBPL1 | TBP-like 1 | 2.18945 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.16595 |
| COL6A3 | collagen, type VI, alpha 3 | 2.16225 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 2.1589 |
| TXNL4B | thioredoxin-like 4B | 2.15545 |
| RIN2 | Ras and Rab interactor 2 | 2.1361 |
| PMM2 | phosphomannomutase 2 | 2.1351 |
| MMP10 | matrix metallopeptidase 10 | 2.12555 |
| ACOT2 | acyl-CoA thioesterase 2 | 2.11805 |
| RBKS | ribokinase | 2.11762 |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 2.1161 |
| NME5 | NME/NM23 family member 5 | 2.10775 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 2.10355 |
| MLF1 | myeloid leukemia factor 1 | 2.10015 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 2.0995 |
| RIMBP2 | RIMS binding protein 2 | 2.0921 |
| GOLM1 | golgi membrane protein 1 | 2.0918 |
| CISH | cytokine inducible SH2-containing protein | 2.0862 |
| IFITM2 | interferon induced transmembrane protein 2 | 2.0783 |
| CSK | c-src tyrosine kinase | 2.07605 |
| TRIL | TLR4 interactor with leucine-rich repeats | 2.0713 |
| MAST3 | microtubule associated serine/threonine kinase 3 | 2.05435 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | 2.03945 |
| MCM3 | minichromosome maintenance complex component 3 | 2.0385 |
| GLB1L | galactosidase, beta 1-like | 2.03045 |
| TRIB2 | tribbles pseudokinase 2 | 2.02915 |
| PLBD1 | phospholipase B domain containing 1 | 2.0263 |
| LIFR | leukemia inhibitory factor receptor alpha | 2.0211 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -8.45145 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -5.3782 |
| SPAG4 | sperm associated antigen 4 | -5.0169 |
| LDHD | lactate dehydrogenase D | -4.8849 |
| TCTN1 | tectonic family member 1 | -4.8479 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.8396 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -4.7986 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.79555 |
| RGS2 | regulator of G-protein signaling 2 | -4.42945 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.4187 |
| ANKRD10 | ankyrin repeat domain 10 | -4.3245 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.96045 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -3.50432 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -3.46315 |
| CCNB1 | cyclin B1 | -3.40105 |
| PLA2G2D | phospholipase A2, group IID | -3.3637 |
| SNX11 | sorting nexin 11 | -3.3182 |
| NCK2 | NCK adaptor protein 2 | -3.1045 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.04182 |
| CCNH | cyclin H | -3.0008 |
| RPS5 | ribosomal protein S5 | -2.9458 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -2.8679 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.8671 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.59485 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | -2.58855 |
| PAGE1 | P antigen family, member 1 (prostate associated) | -2.54695 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -2.52925 |
| WNT11 | wingless-type MMTV integration site family, member 11 | -2.52105 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -2.4414 |
| NUP58 | nucleoporin 58 | -2.42575 |
| RPL18A | ribosomal protein L18a | -2.4248 |
| CAB39 | calcium binding protein 39 | -2.40975 |
| HOXA1 | homeobox A1 | -2.4078 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -2.40335 |
| BCL2A1 | BCL2-related protein A1 | -2.3589 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -2.34825 |
| PRR7 | proline rich 7 (synaptic) | -2.3204 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -2.31715 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -2.3115 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -2.26835 |
| CCP110 | centriolar coiled coil protein 110kDa | -2.2666 |
| FGF17 | fibroblast growth factor 17 | -2.25875 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -2.2442 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -2.2271 |
| CCNE1 | cyclin E1 | -2.21435 |
| MACF1 | microtubule-actin crosslinking factor 1 | -2.20938 |
| HOXD13 | homeobox D13 | -2.19618 |
| PRMT8 | protein arginine methyltransferase 8 | -2.1857 |
| TEC | tec protein tyrosine kinase | -2.17645 |
| GLRA2 | glycine receptor, alpha 2 | -2.1672 |
| CCDC85C | coiled-coil domain containing 85C | -2.164 |
| TMEM165 | transmembrane protein 165 | -2.1632 |
| COX17 | COX17 cytochrome c oxidase copper chaperone | -2.16045 |
| PLEKHM2 | pleckstrin homology domain containing, family M (with RUN domain) member 2 | -2.1598 |
| CCL19 | chemokine (C-C motif) ligand 19 | -2.14245 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -2.13925 |
| HDAC11 | histone deacetylase 11 | -2.1314 |
| KIFBP | kinesin family binding protein | -2.12465 |
| NGRN | neugrin, neurite outgrowth associated | -2.124 |
| FAM8A1 | family with sequence similarity 8, member A1 | -2.1223 |
| LRRC61 | leucine rich repeat containing 61 | -2.1135 |
| TSEN34 | TSEN34 tRNA splicing endonuclease subunit | -2.1079 |
| SEMA3G | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | -2.0997 |
| MORC4 | MORC family CW-type zinc finger 4 | -2.07715 |
| ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 | -2.07595 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | -2.07465 |
| SLC35A5 | solute carrier family 35, member A5 | -2.07155 |
| POLA2 | polymerase (DNA directed), alpha 2, accessory subunit | -2.06925 |
| RMND5A | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | -2.05895 |
| METTL22 | methyltransferase like 22 | -2.05535 |
| CENPM | centromere protein M | -2.0478 |
| CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | -2.04523 |
| UBE3C | ubiquitin protein ligase E3C | -2.04215 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing | -2.03825 |
| ASB7 | ankyrin repeat and SOCS box containing 7 | -2.03195 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -2.02785 |
| TIMELESS | timeless circadian clock | -2.01715 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | -2.0075 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.00545 |
