CRCGN008_HEPG2_24H:H19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2's,6r,7r,z)-7-hydroxy-3',6,7,14-tetramethyl-2,9-dioxa-14-azaspiro[bicyclo[9.5.1]heptadec[11]ene-4,2'-oxirane]-3,8,17-trione 19.93 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN008_HEPG2_24H:H19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 7.39515
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.1996
PPARG peroxisome proliferator-activated receptor gamma 5.13065
NOSIP nitric oxide synthase interacting protein 5.0965
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.1856
CCL2 chemokine (C-C motif) ligand 2 4.09445
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.48413
MAP7 microtubule-associated protein 7 3.39782
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.36383
SCRN1 secernin 1 3.0067
SOCS2 suppressor of cytokine signaling 2 2.85873
GPATCH8 G patch domain containing 8 2.7668
GPER1 G protein-coupled estrogen receptor 1 2.76167
TBP TATA box binding protein 2.589
KIF20A kinesin family member 20A 2.58195
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.4821
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.3511
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.3026
TXNL4B thioredoxin-like 4B 2.3015
MAST2 microtubule associated serine/threonine kinase 2 2.25383
BPHL biphenyl hydrolase-like (serine hydrolase) 2.22355
ADAT1 adenosine deaminase, tRNA-specific 1 2.2153
STXBP2 syntaxin binding protein 2 2.1483
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.1157
PLPPR4 phospholipid phosphatase related 4 2.1062

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -10.0
RPIA ribose 5-phosphate isomerase A -4.93525
ZMIZ1 zinc finger, MIZ-type containing 1 -4.798
CCNB2 cyclin B2 -4.7503
CDC20 cell division cycle 20 -4.66275
LDHD lactate dehydrogenase D -4.36455
SLC35F2 solute carrier family 35, member F2 -4.191
TCTN1 tectonic family member 1 -4.1001
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.79185
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.7597
FASTKD5 FAST kinase domains 5 -3.6643
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.46315
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.29555
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.2272
HSPA8 heat shock 70kDa protein 8 -2.96425
CDC25B cell division cycle 25B -2.88005
WASHC4 WASH complex subunit 4 -2.80898
TLCD3A TLC domain containing 3A -2.7802
CCNB1 cyclin B1 -2.3217
CD58 CD58 molecule -2.30992
PDHX pyruvate dehydrogenase complex, component X -2.22363
DTX2 deltex 2, E3 ubiquitin ligase -2.2235
TM9SF2 transmembrane 9 superfamily member 2 -2.16645
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.14862
ACP3 acid phosphatase 3 -2.12545
BMP4 bone morphogenetic protein 4 -2.08285
RBM34 RNA binding motif protein 34 -2.02063
NMI N-myc (and STAT) interactor -2.0085