CRCGN008_HEPG2_24H:H20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2's,6r,7r,z)-7-hydroxy-3',6,7,14-tetramethyl-2,9-dioxa-14-azaspiro[bicyclo[9.5.1]heptadec[11]ene-4,2'-oxirane]-3,8,17-trione 9.96 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN008_HEPG2_24H:H20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.4173
HLA-DMA major histocompatibility complex, class II, DM alpha 5.63065
JADE2 jade family PHD finger 2 5.45073
RPP38 ribonuclease P/MRP 38kDa subunit 5.2826
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.2021
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.90775
HEBP1 heme binding protein 1 4.87255
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.7875
MYLK myosin light chain kinase 4.43685
CCL2 chemokine (C-C motif) ligand 2 3.9671
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.80562
EGF epidermal growth factor 3.74705
MICALL1 MICAL-like 1 3.60537
TBPL1 TBP-like 1 3.4123
METRN meteorin, glial cell differentiation regulator 3.36325
LPAR2 lysophosphatidic acid receptor 2 3.1478
HLA-DRA major histocompatibility complex, class II, DR alpha 3.05088
MAP7 microtubule-associated protein 7 2.84655
TIAM1 T-cell lymphoma invasion and metastasis 1 2.81715
ZNF331 zinc finger protein 331 2.45015
EPHA3 EPH receptor A3 2.29462
ZNF85 zinc finger protein 85 2.27815
BAMBI BMP and activin membrane-bound inhibitor 2.18915
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.18515
GARRE1 granule associated Rac and RHOG effector 1 2.18335
PTK2 protein tyrosine kinase 2 2.13858
ESRP1 epithelial splicing regulatory protein 1 2.13215
CNPY3 canopy FGF signaling regulator 3 2.11005
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.07293
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.05595
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.05595
KRT34 keratin 34, type I 2.0512
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 2.04005
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 2.0347
RAB31 RAB31, member RAS oncogene family 2.0114

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -5.4526
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.6202
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -4.5616
FASTKD5 FAST kinase domains 5 -4.2565
CCNB2 cyclin B2 -4.11215
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.8865
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.40928
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.03255
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.74908
SNX11 sorting nexin 11 -2.72242
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.62975
NRIP1 nuclear receptor interacting protein 1 -2.57778
CDC25B cell division cycle 25B -2.47
KIFAP3 kinesin-associated protein 3 -2.46685
FER fer (fps/fes related) tyrosine kinase -2.38085
CPAP centrosome assembly and centriole elongation protein -2.3473
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.29393
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.13665
SREK1IP1 SREK1-interacting protein 1 -2.0842
SPAG7 sperm associated antigen 7 -2.05915
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.04515
NCK2 NCK adaptor protein 2 -2.0246