CRCGN008_HEPG2_24H:H21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2's,6r,7r,z)-7-hydroxy-3',6,7,14-tetramethyl-2,9-dioxa-14-azaspiro[bicyclo[9.5.1]heptadec[11]ene-4,2'-oxirane]-3,8,17-trione 4.98 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN008_HEPG2_24H:H21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CBR3 carbonyl reductase 3 4.9335
ANO1 anoctamin 1, calcium activated chloride channel 4.7865
ADRB2 adrenoceptor beta 2, surface 4.72055
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.309
PIH1D1 PIH1 domain containing 1 4.0373
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.89375
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.6911
SNAP25 synaptosomal-associated protein, 25kDa 3.66473
GPER1 G protein-coupled estrogen receptor 1 3.61045
ADAT1 adenosine deaminase, tRNA-specific 1 3.50115
MAP7 microtubule-associated protein 7 3.41002
RPA3 replication protein A3, 14kDa 3.0052
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.93045
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.90275
CDCA4 cell division cycle associated 4 2.7455
CCNF cyclin F 2.69712
RAB31 RAB31, member RAS oncogene family 2.52603
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.52185
CEP57 centrosomal protein 57kDa 2.51172
SNX7 sorting nexin 7 2.3173
KRT23 keratin 23, type I 2.157
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.04948
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.03165
CD40 CD40 molecule, TNF receptor superfamily member 5 2.01434

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.35905
OXA1L oxidase (cytochrome c) assembly 1-like -5.5548
GOLT1B golgi transport 1B -5.04195
LDHD lactate dehydrogenase D -4.94305
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7953
ZNF586 zinc finger protein 586 -4.718
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.6336
ZMIZ1 zinc finger, MIZ-type containing 1 -4.55055
ADI1 acireductone dioxygenase 1 -4.3658
RBM42 RNA binding motif protein 42 -4.16325
SLC35F2 solute carrier family 35, member F2 -3.931
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.8913
HLA-DMA major histocompatibility complex, class II, DM alpha -3.73075
GNAS GNAS complex locus -3.70293
MAPK13 mitogen-activated protein kinase 13 -3.55732
TM9SF3 transmembrane 9 superfamily member 3 -3.48335
CAPNS1 calpain, small subunit 1 -2.9996
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.9657
TMEM147 transmembrane protein 147 -2.9092
PSENEN presenilin enhancer gamma secretase subunit -2.59375
PLA2G15 phospholipase A2, group XV -2.5408
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.51305
RNF167 ring finger protein 167 -2.4885
ZNF146 zinc finger protein 146 -2.20655
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.12795
TBCB tubulin folding cofactor B -2.11413
GPATCH1 G patch domain containing 1 -2.1058
ADIPOR2 adiponectin receptor 2 -2.10285
SNUPN snurportin 1 -2.07575
ANXA11 annexin A11 -2.0222