| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (2's,6r,7r,z)-7-hydroxy-3',6,7,14-tetramethyl-2,9-dioxa-14-azaspiro[bicyclo[9.5.1]heptadec[11]ene-4,2'-oxirane]-3,8,17-trione 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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61 genes differentially expressed following the CRCGN008_HEPG2_24H:H22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.23495 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.21545 |
| ARL4C | ADP-ribosylation factor-like 4C | 4.65248 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 4.29642 |
| NMU | neuromedin U | 4.10715 |
| ABHD6 | abhydrolase domain containing 6 | 3.76678 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.7514 |
| KIFBP | kinesin family binding protein | 3.37395 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.0152 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.98595 |
| MAP7 | microtubule-associated protein 7 | 2.96775 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.9649 |
| MAMLD1 | mastermind-like domain containing 1 | 2.85545 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 2.7761 |
| TXNL4B | thioredoxin-like 4B | 2.66715 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.47685 |
| CYCS | cytochrome c, somatic | 2.41375 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.38355 |
| GPATCH8 | G patch domain containing 8 | 2.37755 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.35085 |
| USP6NL | USP6 N-terminal like | 2.2891 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | 2.25875 |
| MMP1 | matrix metallopeptidase 1 | 2.11383 |
| NAE1 | NEDD8 activating enzyme E1 subunit 1 | 2.07065 |
| EMD | emerin | 2.0675 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 2.0619 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 2.0606 |
| MSN | moesin | 2.04545 |
| CCNF | cyclin F | 2.03695 |
| CPA4 | carboxypeptidase A4 | 2.0034 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -6.52865 |
| CCNB1 | cyclin B1 | -4.90985 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -4.85895 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -4.85725 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.813 |
| PCNA | proliferating cell nuclear antigen | -4.77245 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.7246 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.62225 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -4.56415 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -4.51755 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -4.2069 |
| FASTKD5 | FAST kinase domains 5 | -4.11135 |
| ICAM3 | intercellular adhesion molecule 3 | -3.6799 |
| CCNB2 | cyclin B2 | -3.64985 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -3.44672 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.09075 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.0646 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.85122 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.80195 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.47135 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.4617 |
| TBXAS1 | thromboxane A synthase 1 (platelet) | -2.4208 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.41995 |
| VILL | villin-like | -2.27325 |
| PRPF4 | pre-mRNA processing factor 4 | -2.26125 |
| LILRA5 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 | -2.06135 |
| CYB561D2 | cytochrome b561 family, member D2 | -2.04425 |
| HSD17B3 | hydroxysteroid (17-beta) dehydrogenase 3 | -2.02035 |
| ALX4 | ALX homeobox 4 | -2.01595 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -2.00745 |
| CCDC170 | coiled-coil domain containing 170 | -2.0025 |
