| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (2's,6r,7r,z)-7-hydroxy-3',6,7,14-tetramethyl-2,9-dioxa-14-azaspiro[bicyclo[9.5.1]heptadec[11]ene-4,2'-oxirane]-3,8,17-trione 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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68 genes differentially expressed following the CRCGN008_HEPG2_24H:H23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 5.03565 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.81265 |
| SQOR | sulfide quinone oxidoreductase | 4.6122 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 4.5959 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.5867 |
| RPL39L | ribosomal protein L39-like | 4.4415 |
| E2F2 | E2F transcription factor 2 | 4.4135 |
| PRR15L | proline rich 15-like | 4.3195 |
| HOXA10 | homeobox A10 | 4.22218 |
| EGF | epidermal growth factor | 4.16165 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.9515 |
| PMM2 | phosphomannomutase 2 | 3.68805 |
| MAP7 | microtubule-associated protein 7 | 3.67358 |
| CHN1 | chimerin 1 | 3.5448 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 3.01708 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.95715 |
| VGLL4 | vestigial-like family member 4 | 2.9215 |
| EPHA3 | EPH receptor A3 | 2.65887 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.586 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.4512 |
| S100A8 | S100 calcium binding protein A8 | 2.3707 |
| ECM1 | extracellular matrix protein 1 | 2.3702 |
| HOXA10-HOXA9 | HOXA10-HOXA9 readthrough | 2.33475 |
| PRELID3B | PRELI domain containing 3B | 2.28975 |
| KRT4 | keratin 4, type II | 2.25865 |
| CCDC85B | coiled-coil domain containing 85B | 2.22995 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 2.2296 |
| NKX2-5 | NK2 homeobox 5 | 2.2286 |
| HAND2 | heart and neural crest derivatives expressed 2 | 2.1772 |
| AFF4 | AF4/FMR2 family, member 4 | 2.16995 |
| CRNKL1 | crooked neck pre-mRNA splicing factor 1 | 2.14955 |
| TRIP10 | thyroid hormone receptor interactor 10 | 2.1355 |
| STK10 | serine/threonine kinase 10 | 2.11547 |
| CSDC2 | cold shock domain containing C2, RNA binding | 2.09775 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.0628 |
| TMPRSS11E | transmembrane protease, serine 11E | 2.03165 |
| CALB1 | calbindin 1, 28kDa | 2.03148 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.03015 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | 2.02365 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCDC86 | coiled-coil domain containing 86 | -10.0 |
| CCNB2 | cyclin B2 | -9.115 |
| ANKRD10 | ankyrin repeat domain 10 | -5.6157 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -5.47475 |
| MRPS2 | mitochondrial ribosomal protein S2 | -5.10305 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.6877 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.50385 |
| NGRN | neugrin, neurite outgrowth associated | -3.72975 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -3.6553 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.97777 |
| HSPA8 | heat shock 70kDa protein 8 | -2.72802 |
| PRPF19 | pre-mRNA processing factor 19 | -2.70185 |
| ICAM3 | intercellular adhesion molecule 3 | -2.67595 |
| RGS2 | regulator of G-protein signaling 2 | -2.6402 |
| MEN1 | multiple endocrine neoplasia I | -2.5667 |
| ANO10 | anoctamin 10 | -2.3196 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | -2.3095 |
| PAAF1 | proteasomal ATPase-associated factor 1 | -2.2545 |
| ODR4 | odr-4 GPCR localization factor homolog | -2.21735 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | -2.21385 |
| HSPBAP1 | HSPB (heat shock 27kDa) associated protein 1 | -2.1946 |
| AHNAK | AHNAK nucleoprotein | -2.1507 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -2.1476 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -2.13335 |
| MARCHF8 | membrane associated ring-CH-type finger 8 | -2.09525 |
| ANAPC2 | anaphase promoting complex subunit 2 | -2.0664 |
| MAP1LC3C | microtubule-associated protein 1 light chain 3 gamma | -2.02365 |
| PAEP | progestagen-associated endometrial protein | -2.0218 |
| PRPF4 | pre-mRNA processing factor 4 | -2.00198 |
