CRCGN008_HEPG2_24H:I02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 10.34 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

447 genes differentially expressed following the CRCGN008_HEPG2_24H:I02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 8.5846
TIMP2 TIMP metallopeptidase inhibitor 2 7.7152
CNPY3 canopy FGF signaling regulator 3 7.6604
INPP1 inositol polyphosphate-1-phosphatase 6.94785
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 6.2993
NPDC1 neural proliferation, differentiation and control, 1 6.19665
IER3 immediate early response 3 6.06815
KIFBP kinesin family binding protein 5.91905
GLRX glutaredoxin (thioltransferase) 5.90898
ACOT9 acyl-CoA thioesterase 9 5.87205
RRAGA Ras-related GTP binding A 5.5583
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.5329
TUBB6 tubulin, beta 6 class V 5.2304
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.0567
MVP major vault protein 4.98595
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.8439
S100A4 S100 calcium binding protein A4 4.78605
IGFBP3 insulin-like growth factor binding protein 3 4.69812
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.57945
CCP110 centriolar coiled coil protein 110kDa 4.4976
EGF epidermal growth factor 4.4746
RALB v-ral simian leukemia viral oncogene homolog B 4.39355
DUSP6 dual specificity phosphatase 6 4.37677
VAT1 vesicle amine transport 1 4.3431
SQOR sulfide quinone oxidoreductase 4.3351
DDB2 damage-specific DNA binding protein 2, 48kDa 4.25845
LAP3 leucine aminopeptidase 3 4.22245
BACE2 beta-site APP-cleaving enzyme 2 4.2153
LGALS8 lectin, galactoside-binding, soluble, 8 4.12705
SPAG7 sperm associated antigen 7 4.01565
MICALL1 MICAL-like 1 3.87587
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.79475
CCL2 chemokine (C-C motif) ligand 2 3.6434
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 3.6303
NPC1 Niemann-Pick disease, type C1 3.50307
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.4801
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.4409
TRIB1 tribbles pseudokinase 1 3.3833
JUP junction plakoglobin 3.3813
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 3.2702
BPHL biphenyl hydrolase-like (serine hydrolase) 3.26165
KEAP1 kelch-like ECH-associated protein 1 3.22995
GATA3 GATA binding protein 3 3.19738
NANOS3 nanos homolog 3 (Drosophila) 3.17585
EDN1 endothelin 1 3.15155
GPATCH8 G patch domain containing 8 3.11933
ITFG1 integrin alpha FG-GAP repeat containing 1 3.10595
SSBP2 single-stranded DNA binding protein 2 3.08483
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.97565
CD2AP CD2-associated protein 2.961
TXNL4B thioredoxin-like 4B 2.95755
MAST2 microtubule associated serine/threonine kinase 2 2.87492
TRAM2 translocation associated membrane protein 2 2.87135
TWF2 twinfilin actin binding protein 2 2.86255
FBXO7 F-box protein 7 2.82675
SOX4 SRY (sex determining region Y)-box 4 2.80281
CASC3 cancer susceptibility candidate 3 2.7906
FOS FBJ murine osteosarcoma viral oncogene homolog 2.76085
BLVRA biliverdin reductase A 2.73328
IGF2R insulin-like growth factor 2 receptor 2.72677
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.71513
SUN2 Sad1 and UNC84 domain containing 2 2.7056
MED15 mediator complex subunit 15 2.6978
RHOC ras homolog family member C 2.6931
CDCA4 cell division cycle associated 4 2.68755
ANXA4 annexin A4 2.6752
CYCS cytochrome c, somatic 2.665
CLTB clathrin, light chain B 2.65161
CDPF1 cysteine-rich, DPF motif domain containing 1 2.6401
PRKCD protein kinase C, delta 2.6234
LOC124907782 dual specificity protein phosphatase 22 2.60805
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.59722
AMOTL2 angiomotin like 2 2.59685
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.57485
RBMX2 RNA binding motif protein, X-linked 2 2.55635
ILK integrin-linked kinase 2.55015
SMAD3 SMAD family member 3 2.51416
S100A13 S100 calcium binding protein A13 2.5136
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.50835
TSPAN4 tetraspanin 4 2.48067
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.47613
POLH polymerase (DNA directed), eta 2.4712
MYO1E myosin IE 2.46765
ECD ecdysoneless homolog (Drosophila) 2.4617
ADGRE5 adhesion G protein-coupled receptor E5 2.46115
NMU neuromedin U 2.4499
DSG2 desmoglein 2 2.44
PCDHGA5 protocadherin gamma subfamily A, 5 2.43975
ITGB5 integrin, beta 5 2.43338
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.42075
SQSTM1 sequestosome 1 2.41952
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.41745
BYSL bystin-like 2.41545
PPARG peroxisome proliferator-activated receptor gamma 2.4078
GNL1 guanine nucleotide binding protein-like 1 2.4056
BECN1 beclin 1, autophagy related 2.39218
DCTN2 dynactin 2 (p50) 2.3756
IL18 interleukin 18 2.3692
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.35715
PROCR protein C receptor, endothelial 2.3412
TERF2IP telomeric repeat binding factor 2, interacting protein 2.33905
RNF103 ring finger protein 103 2.32595
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 2.32375
EVL Enah/Vasp-like 2.32115
STXBP2 syntaxin binding protein 2 2.32
RHOG ras homolog family member G 2.3147
FXYD2 FXYD domain containing ion transport regulator 2 2.30833
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.27682
TRIM33 tripartite motif containing 33 2.26576
STXBP1 syntaxin binding protein 1 2.2631
PTCRA pre T-cell antigen receptor alpha 2.26007
BAG6 BCL2-associated athanogene 6 2.24755
STN1 STN1 subunit of CST complex 2.2415
CUL7 cullin 7 2.23763
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.23345
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.20795
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.1954
FLNB filamin B, beta 2.19138
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.18388
WDR13 WD repeat domain 13 2.1765
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.1724
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.1715
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.1681
TOMM34 translocase of outer mitochondrial membrane 34 2.16625
RIOK3 RIO kinase 3 2.16045
LIMA1 LIM domain and actin binding 1 2.1512
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.13825
CDK7 cyclin-dependent kinase 7 2.13105
DYNLT3 dynein, light chain, Tctex-type 3 2.1227
KLHL21 kelch-like family member 21 2.11545
VAMP8 vesicle-associated membrane protein 8 2.11485
PARP2 poly (ADP-ribose) polymerase 2 2.11273
SLC35F2 solute carrier family 35, member F2 2.10745
GIPC1 GIPC PDZ domain containing family, member 1 2.105
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.105
SARS1 seryl-tRNA synthetase 1 2.1039
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.10315
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.09993
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.08153
ZMIZ1 zinc finger, MIZ-type containing 1 2.07975
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 2.07577
MGST3 microsomal glutathione S-transferase 3 2.0746
JOSD1 Josephin domain containing 1 2.06635
NOSIP nitric oxide synthase interacting protein 2.05985
ADGRF5 adhesion G protein-coupled receptor F5 2.05673
BCL10 B-cell CLL/lymphoma 10 2.05215
FBXW4 F-box and WD repeat domain containing 4 2.04435
MICU2 mitochondrial calcium uptake 2 2.03875
MICA MHC class I polypeptide-related sequence A 2.0366
CSNK1E casein kinase 1, epsilon 2.03655
DOCK6 dedicator of cytokinesis 6 2.03352
MACF1 microtubule-actin crosslinking factor 1 2.02915
BCAS3 breast carcinoma amplified sequence 3 2.02865
GTPBP8 GTP-binding protein 8 (putative) 2.02635
ACLY ATP citrate lyase 2.02515

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -9.51135
CDC20 cell division cycle 20 -9.4308
PLK1 polo-like kinase 1 -7.76145
PSRC1 proline/serine-rich coiled-coil 1 -7.19985
ANKRD10 ankyrin repeat domain 10 -6.96675
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -6.69497
C5 complement component 5 -6.53025
ZNF586 zinc finger protein 586 -6.51235
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.35285
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -6.23695
ISOC1 isochorismatase domain containing 1 -6.05685
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -5.85847
TRIB3 tribbles pseudokinase 3 -5.75145
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.70885
ICAM3 intercellular adhesion molecule 3 -5.5676
OXA1L oxidase (cytochrome c) assembly 1-like -5.54505
NRIP1 nuclear receptor interacting protein 1 -5.44815
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.2799
RXYLT1 ribitol xylosyltransferase 1 -5.02105
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.9442
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.71242
RUVBL1 RuvB-like AAA ATPase 1 -4.70835
FASTKD5 FAST kinase domains 5 -4.61655
PCNA proliferating cell nuclear antigen -4.6007
CDK1 cyclin-dependent kinase 1 -4.4728
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -4.35
TOP2A topoisomerase (DNA) II alpha 170kDa -4.34095
TCERG1 transcription elongation regulator 1 -4.31155
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.3062
CCNA2 cyclin A2 -4.26077
DDIT4 DNA-damage-inducible transcript 4 -4.2276
AURKB aurora kinase B -4.2077
HLA-DMA major histocompatibility complex, class II, DM alpha -3.9658
GOLT1B golgi transport 1B -3.95105
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.69475
TCTN1 tectonic family member 1 -3.67205
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.6692
RPIA ribose 5-phosphate isomerase A -3.62335
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -3.55875
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.5409
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -3.5332
NENF neudesin neurotrophic factor -3.48488
GNAS GNAS complex locus -3.4517
MELK maternal embryonic leucine zipper kinase -3.4495
THAP11 THAP domain containing 11 -3.4065
BIRC5 baculoviral IAP repeat containing 5 -3.37385
LBR lamin B receptor -3.3034
CCNB1 cyclin B1 -3.2918
LAGE3 L antigen family, member 3 -3.2056
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.15075
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -3.1342
AQP4 aquaporin 4 -3.13366
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.05965
CDCA3 cell division cycle associated 3 -3.0559
RPP38 ribonuclease P/MRP 38kDa subunit -3.01225
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.9992
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.9977
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -2.9798
PEG10 paternally expressed 10 -2.93183
E2F5 E2F transcription factor 5, p130-binding -2.92895
LYRM1 LYR motif containing 1 -2.9214
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.90165
UBE2C ubiquitin-conjugating enzyme E2C -2.8955
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 -2.88925
CTNND2 catenin (cadherin-associated protein), delta 2 -2.88882
COG4 component of oligomeric golgi complex 4 -2.88495
CCNF cyclin F -2.88095
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.8499
HSPA14 heat shock 70kDa protein 14 -2.84665
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.84185
PRUNE1 prune exopolyphosphatase 1 -2.8151
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.81087
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.79815
CDK6 cyclin-dependent kinase 6 -2.7654
FAM110A family with sequence similarity 110, member A -2.73405
HMGN2 high mobility group nucleosomal binding domain 2 -2.7276
DERA deoxyribose-phosphate aldolase (putative) -2.7224
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -2.69575
PECR peroxisomal trans-2-enoyl-CoA reductase -2.6901
RPH3A rabphilin 3A -2.6789
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.6653
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.6543
PIPOX pipecolic acid oxidase -2.65285
NLRP2B NLR family pyrin domain containing 2B -2.6481
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.64375
INTS3 integrator complex subunit 3 -2.63775
SOAT2 sterol O-acyltransferase 2 -2.626
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 -2.6212
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.61825
ENTREP2 endosomal transmembrane epsin interactor 2 -2.6171
TTPA tocopherol (alpha) transfer protein -2.6058
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) -2.60425
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.5984
ZNF606 zinc finger protein 606 -2.59355
RBM15B RNA binding motif protein 15B -2.59025
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.58745
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.58455
TMEM176A transmembrane protein 176A -2.56745
RPGRIP1L RPGRIP1-like -2.56425
F13B coagulation factor XIII, B polypeptide -2.56365
PREB prolactin regulatory element binding -2.56155
SMIM10L1 small integral membrane protein 10 like 1 -2.55435
PGRMC1 progesterone receptor membrane component 1 -2.5517
TDO2 tryptophan 2,3-dioxygenase -2.55145
H2AZ1 H2A.Z variant histone 1 -2.55017
RABEPK Rab9 effector protein with kelch motifs -2.54845
CNGA3 cyclic nucleotide gated channel alpha 3 -2.53755
UBE3C ubiquitin protein ligase E3C -2.53225
HMGB2 high mobility group box 2 -2.52985
GTF2A2 general transcription factor IIA, 2, 12kDa -2.52645
A1CF APOBEC1 complementation factor -2.52455
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.52195
COPS7A COP9 signalosome subunit 7A -2.5195
CENPE centromere protein E, 312kDa -2.5121
HADH hydroxyacyl-CoA dehydrogenase -2.51117
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.50715
TOMM70 translocase of outer mitochondrial membrane 70 -2.49635
AGXT alanine-glyoxylate aminotransferase -2.496
COQ3 coenzyme Q3 methyltransferase -2.49565
C2CD5 C2 calcium-dependent domain containing 5 -2.49425
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.4916
CFHR5 complement factor H-related 5 -2.48795
TTYH1 tweety family member 1 -2.48765
GPR19 G protein-coupled receptor 19 -2.48555
ENOPH1 enolase-phosphatase 1 -2.4808
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.48055
MAPK13 mitogen-activated protein kinase 13 -2.47555
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -2.4749
ASTN1 astrotactin 1 -2.47075
APCS amyloid P component, serum -2.4706
WFS1 Wolfram syndrome 1 (wolframin) -2.46955
RBM34 RNA binding motif protein 34 -2.45355
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.4412
MYCBP MYC binding protein -2.40912
LIPG lipase, endothelial -2.40905
SH3D19 SH3 domain containing 19 -2.4028
CFHR3 complement factor H-related 3 -2.3973
ZNF143 zinc finger protein 143 -2.39125
SNTG1 syntrophin, gamma 1 -2.3911
PEX11A peroxisomal biogenesis factor 11 alpha -2.38925
CARD8 caspase recruitment domain family, member 8 -2.38915
SCN1A sodium channel, voltage gated, type I alpha subunit -2.38485
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 -2.37595
SP4 Sp4 transcription factor -2.37585
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.3758
MANEA mannosidase, endo-alpha -2.37115
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.36955
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 -2.36518
KIF15 kinesin family member 15 -2.3628
SDF2L1 stromal cell-derived factor 2-like 1 -2.36075
CCL15 chemokine (C-C motif) ligand 15 -2.3572
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.35495
AMELX amelogenin, X-linked -2.3515
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.34925
TRA2B transformer 2 beta homolog (Drosophila) -2.34828
GAP43 growth associated protein 43 -2.34415
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.332
NR2E1 nuclear receptor subfamily 2, group E, member 1 -2.3303
LOC128966622 putative protein N-methyltransferase FAM86B2 -2.32495
RNF32 ring finger protein 32 -2.31635
SCRG1 stimulator of chondrogenesis 1 -2.31545
WBP11 WW domain binding protein 11 -2.3145
ZIM3 zinc finger, imprinted 3 -2.31345
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.31125
KDM4D lysine (K)-specific demethylase 4D -2.30765
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -2.2989
FZD7 frizzled class receptor 7 -2.29395
PRH1-TAS2R14 PRH1-TAS2R14 readthrough -2.2938
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.29015
DENND2D DENN/MADD domain containing 2D -2.2896
NCAPD2 non-SMC condensin I complex, subunit D2 -2.2809
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -2.27695
NECTIN3 nectin cell adhesion molecule 3 -2.2667
POLR1G RNA polymerase I subunit G -2.26645
CPNE2 copine II -2.26335
SDC3 syndecan 3 -2.26145
ANGPTL3 angiopoietin-like 3 -2.2587
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.25373
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.25035
MLEC malectin -2.24907
TRMT5 tRNA methyltransferase 5 -2.24545
CHERP calcium homeostasis endoplasmic reticulum protein -2.2437
F9 coagulation factor IX -2.24165
SRFBP1 serum response factor binding protein 1 -2.24075
CHEK2 checkpoint kinase 2 -2.24065
RIT2 Ras-like without CAAX 2 -2.23595
CDH10 cadherin 10, type 2 (T2-cadherin) -2.2322
MRPS31 mitochondrial ribosomal protein S31 -2.23115
HSPA8 heat shock 70kDa protein 8 -2.22782
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 -2.2256
ADPRH ADP-ribosylarginine hydrolase -2.2211
KIF4A kinesin family member 4A -2.2121
SMIM8 small integral membrane protein 8 -2.20932
CFHR2 complement factor H-related 2 -2.2047
LECT2 leukocyte cell-derived chemotaxin 2 -2.1999
GYS2 glycogen synthase 2 (liver) -2.1988
TRABD TraB domain containing -2.1986
BLM Bloom syndrome, RecQ helicase-like -2.19845
SPATA1 spermatogenesis associated 1 -2.1983
ZNF302 zinc finger protein 302 -2.1951
ADH6 alcohol dehydrogenase 6 (class V) -2.1951
SLC17A2 solute carrier family 17, member 2 -2.1949
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.1911
PON1 paraoxonase 1 -2.18878
SLC38A4 solute carrier family 38, member 4 -2.1887
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.1831
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 -2.17985
MRPL3 mitochondrial ribosomal protein L3 -2.17715
TRMT61B tRNA methyltransferase 61B -2.17485
NUP88 nucleoporin 88kDa -2.1743
KHK ketohexokinase (fructokinase) -2.1596
EMC8 ER membrane protein complex subunit 8 -2.159
CA5A carbonic anhydrase VA, mitochondrial -2.15845
FRMPD1 FERM and PDZ domain containing 1 -2.15665
UBE2S ubiquitin-conjugating enzyme E2S -2.15635
AFM afamin -2.1539
TMEM97 transmembrane protein 97 -2.15129
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.14995
TROAP trophinin associated protein -2.13405
RBMXL2 RNA binding motif protein, X-linked-like 2 -2.1338
THAP9 THAP domain containing 9 -2.1297
MSH4 mutS homolog 4 -2.12535
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -2.12263
PCDHGA3 protocadherin gamma subfamily A, 3 -2.1216
TRIM9 tripartite motif containing 9 -2.1197
OIP5 Opa interacting protein 5 -2.1195
C8B complement component 8, beta polypeptide -2.1177
TEDC2 tubulin epsilon and delta complex 2 -2.1147
MTTP microsomal triglyceride transfer protein -2.1138
DEFA5 defensin, alpha 5, Paneth cell-specific -2.11145
CDKN3 cyclin-dependent kinase inhibitor 3 -2.11115
CRELD2 cysteine-rich with EGF-like domains 2 -2.108
TMEM260 transmembrane protein 260 -2.10725
MAP2K6 mitogen-activated protein kinase kinase 6 -2.10637
JTB jumping translocation breakpoint -2.10297
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase -2.09632
MOGAT2 monoacylglycerol O-acyltransferase 2 -2.09463
DIRAS2 DIRAS family, GTP-binding RAS-like 2 -2.09445
S100G S100 calcium binding protein G -2.0937
PMP2 peripheral myelin protein 2 -2.0925
ZNF415 zinc finger protein 415 -2.0906
TMEM158 transmembrane protein 158 (gene/pseudogene) -2.08965
MIS18A MIS18 kinetochore protein A -2.0887
BORA bora, aurora kinase A activator -2.087
C8G complement component 8, gamma polypeptide -2.08405
CERS1 ceramide synthase 1 -2.08225
CENPA centromere protein A -2.0803
MAOB monoamine oxidase B -2.07745
CETN3 centrin, EF-hand protein, 3 -2.0751
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -2.07055
SRSF2 serine/arginine-rich splicing factor 2 -2.0678
ZNF442 zinc finger protein 442 -2.067
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.06687
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 -2.0668
RNFT2 ring finger protein, transmembrane 2 -2.06625
HAT1 histone acetyltransferase 1 -2.06415
TBCEL tubulin folding cofactor E-like -2.063
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase -2.06185
UBXN2B UBX domain protein 2B -2.05715
PKNOX2 PBX/knotted 1 homeobox 2 -2.05567
PCDH8 protocadherin 8 -2.0517
TMEM161A transmembrane protein 161A -2.04938
JMJD4 jumonji domain containing 4 -2.0458
SLC30A10 solute carrier family 30, member 10 -2.0396
CALB2 calbindin 2 -2.0356
FABP7 fatty acid binding protein 7, brain -2.03442
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.0323
PCDHB1 protocadherin beta 1 -2.0307
CCNC cyclin C -2.02965
ZCCHC4 zinc finger, CCHC domain containing 4 -2.02958
PTTG1 pituitary tumor-transforming 1 -2.0293
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.02825
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.02747
KCNIP1 Kv channel interacting protein 1 -2.02625
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.02475
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.02455
MRPL11 mitochondrial ribosomal protein L11 -2.01835
UMPS uridine monophosphate synthetase -2.0151
NXT2 nuclear transport factor 2-like export factor 2 -2.01482
NCAN neurocan -2.0137
FADD Fas (TNFRSF6)-associated via death domain -2.0124
PNPLA3 patatin-like phospholipase domain containing 3 -2.00945
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.00865
IFFO1 intermediate filament family orphan 1 -2.008
LATS1 large tumor suppressor kinase 1 -2.0076
DNAAF2 dynein, axonemal, assembly factor 2 -2.0075
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.00735
LRP1B low density lipoprotein receptor-related protein 1B -2.0054
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.00535
TUBGCP3 tubulin, gamma complex associated protein 3 -2.0051
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.00405
EAPP E2F-associated phosphoprotein -2.00115