CRCGN008_HEPG2_24H:I03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 5.17 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

611 genes differentially expressed following the CRCGN008_HEPG2_24H:I03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIMP2 TIMP metallopeptidase inhibitor 2 8.9887
CNPY3 canopy FGF signaling regulator 3 8.8347
INPP1 inositol polyphosphate-1-phosphatase 7.92085
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 7.37415
TUBB6 tubulin, beta 6 class V 7.0164
KIFBP kinesin family binding protein 6.7237
LSR lipolysis stimulated lipoprotein receptor 6.70425
IER3 immediate early response 3 6.3445
IGFBP3 insulin-like growth factor binding protein 3 5.85732
PPARG peroxisome proliferator-activated receptor gamma 5.77255
GLRX glutaredoxin (thioltransferase) 5.2851
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0847
ACOT9 acyl-CoA thioesterase 9 5.07235
S100A4 S100 calcium binding protein A4 5.02955
MVP major vault protein 4.92425
CIAO3 cytosolic iron-sulfur assembly component 3 4.8296
CCDC92 coiled-coil domain containing 92 4.7982
BACE2 beta-site APP-cleaving enzyme 2 4.7738
NOTCH1 notch 1 4.62625
SQOR sulfide quinone oxidoreductase 4.59665
LGALS8 lectin, galactoside-binding, soluble, 8 4.58578
RRAGA Ras-related GTP binding A 4.5274
CCP110 centriolar coiled coil protein 110kDa 4.33155
DDB2 damage-specific DNA binding protein 2, 48kDa 4.30255
DUSP6 dual specificity phosphatase 6 4.18077
AMDHD2 amidohydrolase domain containing 2 4.1208
GATA2 GATA binding protein 2 4.03562
LCN2 lipocalin 2 3.9928
FOS FBJ murine osteosarcoma viral oncogene homolog 3.94255
SPAG7 sperm associated antigen 7 3.70795
METRN meteorin, glial cell differentiation regulator 3.4849
ANTKMT adenine nucleotide translocase lysine methyltransferase 3.42565
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.3246
TRIB1 tribbles pseudokinase 1 3.3204
CYCS cytochrome c, somatic 3.2921
SLC35F2 solute carrier family 35, member F2 3.2859
TERF2IP telomeric repeat binding factor 2, interacting protein 3.20665
ITFG1 integrin alpha FG-GAP repeat containing 1 3.19805
TWF2 twinfilin actin binding protein 2 3.1408
RALB v-ral simian leukemia viral oncogene homolog B 3.12413
MICALL1 MICAL-like 1 3.06485
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.0351
LOC124907782 dual specificity protein phosphatase 22 3.019
CST7 cystatin F (leukocystatin) 3.0052
LAP3 leucine aminopeptidase 3 2.99285
NPC1 Niemann-Pick disease, type C1 2.98712
JADE2 jade family PHD finger 2 2.9709
ZFP36 ZFP36 ring finger protein 2.9649
AMOTL2 angiomotin like 2 2.9013
SOX4 SRY (sex determining region Y)-box 4 2.89193
CD2 CD2 molecule 2.8774
GOLT1B golgi transport 1B 2.8663
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.8662
ECD ecdysoneless homolog (Drosophila) 2.86095
CCNH cyclin H 2.82185
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.80715
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.79135
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.7894
GBE1 glucan (1,4-alpha-), branching enzyme 1 2.78325
MCOLN1 mucolipin 1 2.7708
CD58 CD58 molecule 2.74897
STXBP2 syntaxin binding protein 2 2.74305
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 2.73377
PXDC1 PX domain containing 1 2.72685
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.69558
FBN1 fibrillin 1 2.68475
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 2.6808
LIMA1 LIM domain and actin binding 1 2.66945
S100A13 S100 calcium binding protein A13 2.66385
IGF2R insulin-like growth factor 2 receptor 2.66323
SKIC2 SKI2 subunit of superkiller complex 2.65455
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.6402
CYTH1 cytohesin 1 2.63063
PTCRA pre T-cell antigen receptor alpha 2.62205
FAT1 FAT atypical cadherin 1 2.6195
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.61455
PLSCR3 phospholipid scramblase 3 2.60503
CDPF1 cysteine-rich, DPF motif domain containing 1 2.5981
PMM2 phosphomannomutase 2 2.59505
CDK7 cyclin-dependent kinase 7 2.5798
GZMK granzyme K (granzyme 3; tryptase II) 2.56035
NANOS3 nanos homolog 3 (Drosophila) 2.55785
GTPBP8 GTP-binding protein 8 (putative) 2.5549
BLVRA biliverdin reductase A 2.54805
TBC1D15 TBC1 domain family, member 15 2.5415
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.54115
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.5409
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.53255
CLTB clathrin, light chain B 2.51487
NBAS neuroblastoma amplified sequence 2.49775
EDN1 endothelin 1 2.49375
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.4619
MBNL2 muscleblind-like splicing regulator 2 2.46042
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.45005
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.44565
ARHGAP10 Rho GTPase activating protein 10 2.44045
ITGAV integrin, alpha V 2.4396
SUN2 Sad1 and UNC84 domain containing 2 2.43705
SERINC1 serine incorporator 1 2.436
EGR1 early growth response 1 2.42315
FBXO7 F-box protein 7 2.41945
IL7R interleukin 7 receptor 2.4185
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.4131
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.41185
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.3968
TXNRD1 thioredoxin reductase 1 2.3966
XAB2 XPA binding protein 2 2.3724
RABEP2 rabaptin, RAB GTPase binding effector protein 2 2.37093
MED15 mediator complex subunit 15 2.3469
CASC3 cancer susceptibility candidate 3 2.3451
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.34165
XPC xeroderma pigmentosum, complementation group C 2.3325
TMEM135 transmembrane protein 135 2.3277
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.308
PTGES prostaglandin E synthase 2.30725
GIPC1 GIPC PDZ domain containing family, member 1 2.30495
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.30295
SEC24C SEC24 family member C 2.2973
YIPF3 Yip1 domain family, member 3 2.2954
PRKCD protein kinase C, delta 2.28285
ANGPTL4 angiopoietin-like 4 2.27605
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.27245
INPP5K inositol polyphosphate-5-phosphatase K 2.2694
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.25625
ACTN4 actinin, alpha 4 2.23265
CCL5 chemokine (C-C motif) ligand 5 2.2248
PTPN3 protein tyrosine phosphatase, non-receptor type 3 2.21005
DOHH deoxyhypusine hydroxylase/monooxygenase 2.20555
BIRC3 baculoviral IAP repeat containing 3 2.20485
FRG1 FSHD region gene 1 2.1976
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.1832
WIPF1 WAS/WASL interacting protein family, member 1 2.17855
P3H3 prolyl 3-hydroxylase 3 2.1677
DYNLT3 dynein, light chain, Tctex-type 3 2.1636
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.15772
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2.15427
CDC25B cell division cycle 25B 2.15355
PRSS22 protease, serine, 22 2.14885
TMEM59 transmembrane protein 59 2.1382
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.13225
SFXN3 sideroflexin 3 2.12602
CD8A CD8a molecule 2.1246
MYO6 myosin VI 2.12147
PNKP polynucleotide kinase 3'-phosphatase 2.12035
DUSP4 dual specificity phosphatase 4 2.11863
ITGB5 integrin, beta 5 2.1186
TAC4 tachykinin 4 (hemokinin) 2.1182
SQSTM1 sequestosome 1 2.11547
LTB lymphotoxin beta (TNF superfamily, member 3) 2.1154
SYF2 SYF2 pre-mRNA-splicing factor 2.11135
GNB5 guanine nucleotide binding protein (G protein), beta 5 2.10667
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.10035
GARRE1 granule associated Rac and RHOG effector 1 2.0981
WDR13 WD repeat domain 13 2.0883
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.08515
GBA1 glucosylceramidase beta 1 2.08505
OPTN optineurin 2.07245
DCK deoxycytidine kinase 2.06875
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.04325
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.0387
BORCS6 BLOC-1 related complex subunit 6 2.0363
ELP3 elongator acetyltransferase complex subunit 3 2.03535
CUL7 cullin 7 2.0326
ARID4B AT rich interactive domain 4B (RBP1-like) 2.0274
POLH polymerase (DNA directed), eta 2.01615
PRPF38B pre-mRNA processing factor 38B 2.01312
NT5E 5'-nucleotidase, ecto (CD73) 2.00625
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 2.00505
IL2RB interleukin 2 receptor, beta 2.00155
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.0012
ANXA4 annexin A4 2.00063
CHN1 chimerin 1 2.00005

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -9.97805
ISOC1 isochorismatase domain containing 1 -9.6304
NT5DC2 5'-nucleotidase domain containing 2 -9.18145
PSRC1 proline/serine-rich coiled-coil 1 -8.46405
PLK1 polo-like kinase 1 -8.29325
ANKRD10 ankyrin repeat domain 10 -6.62345
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.3539
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -6.2475
ZDHHC6 zinc finger, DHHC-type containing 6 -6.08825
FGFR4 fibroblast growth factor receptor 4 -6.00497
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -5.6627
CCNB1 cyclin B1 -5.50965
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.13665
OXA1L oxidase (cytochrome c) assembly 1-like -5.0962
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -5.0297
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.73952
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.68258
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.66275
RUVBL1 RuvB-like AAA ATPase 1 -4.6467
HLA-DMA major histocompatibility complex, class II, DM alpha -4.5858
FASTKD5 FAST kinase domains 5 -4.46435
BIRC5 baculoviral IAP repeat containing 5 -4.43713
AURKB aurora kinase B -4.41095
LDHD lactate dehydrogenase D -4.2275
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.16855
NIT1 nitrilase 1 -4.05365
ZMIZ1 zinc finger, MIZ-type containing 1 -4.0081
DDIT4 DNA-damage-inducible transcript 4 -4.00775
NLRP2B NLR family pyrin domain containing 2B -3.9929
TCTN1 tectonic family member 1 -3.97015
RPIA ribose 5-phosphate isomerase A -3.9562
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -3.95405
RFC2 replication factor C (activator 1) 2, 40kDa -3.92858
LBR lamin B receptor -3.91335
UBE2C ubiquitin-conjugating enzyme E2C -3.87665
LAGE3 L antigen family, member 3 -3.8446
TOP2A topoisomerase (DNA) II alpha 170kDa -3.81932
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.81175
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.80955
TCERG1 transcription elongation regulator 1 -3.76265
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.7367
DSG2 desmoglein 2 -3.69665
GNAS GNAS complex locus -3.67141
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.63645
GSTM2 glutathione S-transferase mu 2 (muscle) -3.6211
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.61945
NENF neudesin neurotrophic factor -3.5323
PECR peroxisomal trans-2-enoyl-CoA reductase -3.5205
RBM15B RNA binding motif protein 15B -3.46325
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.4272
ZNF586 zinc finger protein 586 -3.4109
CCNA2 cyclin A2 -3.3421
SH3D19 SH3 domain containing 19 -3.31472
SOAT2 sterol O-acyltransferase 2 -3.2975
MIS18A MIS18 kinetochore protein A -3.29695
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.29485
VAT1 vesicle amine transport 1 -3.27945
FAM184A family with sequence similarity 184, member A -3.1784
LIN28A lin-28 homolog A (C. elegans) -3.1702
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -3.09375
MRPL12 mitochondrial ribosomal protein L12 -3.06105
ZIC3 Zic family member 3 -3.0582
PIPOX pipecolic acid oxidase -3.03745
CDK1 cyclin-dependent kinase 1 -3.02452
CRIPTO3 cripto, EGF-CFC family member 3 -2.9667
DNAAF5 dynein, axonemal, assembly factor 5 -2.9614
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.9601
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -2.9346
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.9345
LRRC2 leucine rich repeat containing 2 -2.93355
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.91297
LYRM1 LYR motif containing 1 -2.90295
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.88335
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.88285
LRRTM4 leucine rich repeat transmembrane neuronal 4 -2.87015
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.86325
SPATA6 spermatogenesis associated 6 -2.833
CER1 cerberus 1, DAN family BMP antagonist -2.83185
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.80795
AQP4 aquaporin 4 -2.80096
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.78245
HADH hydroxyacyl-CoA dehydrogenase -2.77623
CFHR5 complement factor H-related 5 -2.7603
INTS3 integrator complex subunit 3 -2.7521
PCDHB1 protocadherin beta 1 -2.7205
ERCC6L excision repair cross-complementation group 6-like -2.71995
POLD2 polymerase (DNA directed), delta 2, accessory subunit -2.71027
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.71023
HEBP1 heme binding protein 1 -2.70475
OR7E24 olfactory receptor, family 7, subfamily E, member 24 -2.6984
THAP9 THAP domain containing 9 -2.69765
PKNOX2 PBX/knotted 1 homeobox 2 -2.6951
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.67725
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -2.67555
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.67355
COX6C cytochrome c oxidase subunit VIc -2.66445
ZNF334 zinc finger protein 334 -2.65295
SCG3 secretogranin III -2.64415
RPP38 ribonuclease P/MRP 38kDa subunit -2.6354
ERI3 ERI1 exoribonuclease family member 3 -2.62895
GYG2 glycogenin 2 -2.6271
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.61315
CTNND2 catenin (cadherin-associated protein), delta 2 -2.61127
ELAVL1 ELAV like RNA binding protein 1 -2.59932
HYOU1 hypoxia up-regulated 1 -2.5989
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.59745
UBE2S ubiquitin-conjugating enzyme E2S -2.5963
CD320 CD320 molecule -2.5951
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.58735
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.58283
CLDN10 claudin 10 -2.57825
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.57445
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.5737
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.569
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.56505
FBXL12 F-box and leucine-rich repeat protein 12 -2.5648
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.56275
TRMT5 tRNA methyltransferase 5 -2.56235
SNAP25 synaptosomal-associated protein, 25kDa -2.5548
MELK maternal embryonic leucine zipper kinase -2.5515
MTHFSD methenyltetrahydrofolate synthetase domain containing -2.5459
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.5459
FAM76A family with sequence similarity 76, member A -2.53835
HSPA8 heat shock 70kDa protein 8 -2.5379
CA5A carbonic anhydrase VA, mitochondrial -2.53755
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.53755
JAKMIP2 janus kinase and microtubule interacting protein 2 -2.5368
MYF6 myogenic factor 6 (herculin) -2.53565
SRRD SRR1 domain containing -2.53015
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -2.52955
ASGR1 asialoglycoprotein receptor 1 -2.52915
PDZD2 PDZ domain containing 2 -2.52655
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.52635
CASQ2 calsequestrin 2 (cardiac muscle) -2.5262
ACTN2 actinin, alpha 2 -2.52432
SCARB1 scavenger receptor class B, member 1 -2.52295
TXNRD3 thioredoxin reductase 3 -2.51503
SYCP1 synaptonemal complex protein 1 -2.51175
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.5102
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.50575
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) -2.50165
CLCN2 chloride channel, voltage-sensitive 2 -2.49725
ZNF835 zinc finger protein 835 -2.49345
CDK4 cyclin-dependent kinase 4 -2.4912
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.48785
GSTM4 glutathione S-transferase mu 4 -2.48697
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.4859
MPHOSPH6 M-phase phosphoprotein 6 -2.4827
CHEK2 checkpoint kinase 2 -2.4814
TPM3 tropomyosin 3 -2.4721
PYCR1 pyrroline-5-carboxylate reductase 1 -2.47105
NCAPD2 non-SMC condensin I complex, subunit D2 -2.46665
ADISSP adipose secreted signaling protein -2.45848
RABL3 RAB, member of RAS oncogene family-like 3 -2.4575
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 -2.45276
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -2.44775
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -2.44765
HYDIN HYDIN, axonemal central pair apparatus protein -2.4474
TRHR thyrotropin-releasing hormone receptor -2.44495
CETN3 centrin, EF-hand protein, 3 -2.44465
TMEM177 transmembrane protein 177 -2.44395
TTC26 tetratricopeptide repeat domain 26 -2.44285
ZC2HC1C zinc finger, C2HC-type containing 1C -2.4413
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -2.4355
ATL2 atlastin GTPase 2 -2.43505
LEFTY1 left-right determination factor 1 -2.42975
ADA2 adenosine deaminase 2 -2.42945
GPC3 glypican 3 -2.4277
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 -2.4252
ZNF606 zinc finger protein 606 -2.42215
MSH4 mutS homolog 4 -2.4153
HMGN2 high mobility group nucleosomal binding domain 2 -2.41255
SRSF2 serine/arginine-rich splicing factor 2 -2.41143
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.4103
RND2 Rho family GTPase 2 -2.40998
TEX15 testis expressed 15 -2.40915
MYCBP MYC binding protein -2.40545
GRID2 glutamate receptor, ionotropic, delta 2 -2.40543
TBC1D31 TBC1 domain family, member 31 -2.40375
TAS2R4 taste receptor, type 2, member 4 -2.39995
TCEAL2 transcription elongation factor A (SII)-like 2 -2.39335
AURKC aurora kinase C -2.39155
SCGB1D1 secretoglobin, family 1D, member 1 -2.39097
CENPS-CORT CENPS-CORT readthrough -2.38455
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.37635
RIT2 Ras-like without CAAX 2 -2.37615
SNTG1 syntrophin, gamma 1 -2.37505
TRIM24 tripartite motif containing 24 -2.37242
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.3603
EMC8 ER membrane protein complex subunit 8 -2.3585
CDCA3 cell division cycle associated 3 -2.35455
C5 complement component 5 -2.354
ZNF471 zinc finger protein 471 -2.35265
CYB5R1 cytochrome b5 reductase 1 -2.3525
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.3513
NANOG Nanog homeobox -2.34625
RUVBL2 RuvB-like AAA ATPase 2 -2.3443
KDM4D lysine (K)-specific demethylase 4D -2.3436
RAPSN receptor-associated protein of the synapse -2.34095
LOC128966622 putative protein N-methyltransferase FAM86B2 -2.33775
GOLGA6B golgin A6 family, member B -2.3344
SCN1A sodium channel, voltage gated, type I alpha subunit -2.3288
PARP1 poly (ADP-ribose) polymerase 1 -2.32795
PPP4R4 protein phosphatase 4, regulatory subunit 4 -2.3268
LY86 lymphocyte antigen 86 -2.3228
STAMBP STAM binding protein -2.3224
DPPA4 developmental pluripotency associated 4 -2.31905
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.3171
LOC128966586 pepsin A-4-like -2.31675
RIMS1 regulating synaptic membrane exocytosis 1 -2.31305
KERA keratocan -2.3114
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.30862
LUZP2 leucine zipper protein 2 -2.305
COL5A3 collagen, type V, alpha 3 -2.30415
AMT aminomethyltransferase -2.2992
PLAAT1 phospholipase A and acyltransferase 1 -2.29865
CLEC4E C-type lectin domain family 4, member E -2.2974
DTNA dystrobrevin, alpha -2.29009
ANKRD7 ankyrin repeat domain 7 -2.2895
AURKA aurora kinase A -2.28118
TNN tenascin N -2.28115
HNMT histamine N-methyltransferase -2.27363
AMELX amelogenin, X-linked -2.27225
L1TD1 LINE-1 type transposase domain containing 1 -2.27155
MYEF2 myelin expression factor 2 -2.27145
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.2629
TMEM231 transmembrane protein 231 -2.26235
IL24 interleukin 24 -2.2613
AMOT angiomotin -2.26115
MYLK3 myosin light chain kinase 3 -2.2607
MATN2 matrilin 2 -2.2595
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -2.2587
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.25785
CPNE2 copine II -2.2572
ZBTB33 zinc finger and BTB domain containing 33 -2.2567
PON1 paraoxonase 1 -2.25475
NUP62 nucleoporin 62kDa -2.25448
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 -2.24855
ZMYM4 zinc finger, MYM-type 4 -2.24842
ISOC2 isochorismatase domain containing 2 -2.2466
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.2458
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.24245
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.24225
ENTR1 endosome associated trafficking regulator 1 -2.2408
PPARA peroxisome proliferator-activated receptor alpha -2.23143
RLBP1 retinaldehyde binding protein 1 -2.23065
FRMPD1 FERM and PDZ domain containing 1 -2.2304
YBX2 Y box binding protein 2 -2.22715
CAV3 caveolin 3 -2.22605
GPR19 G protein-coupled receptor 19 -2.22595
FOXA2 forkhead box A2 -2.22385
JAM2 junctional adhesion molecule 2 -2.22125
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 -2.21855
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -2.21847
UBE3C ubiquitin protein ligase E3C -2.2182
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.2155
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.21375
PIAS2 protein inhibitor of activated STAT, 2 -2.21255
ASXL3 additional sex combs like transcriptional regulator 3 -2.2123
MAGEA8 melanoma antigen family A8 -2.21195
WDR77 WD repeat domain 77 -2.21088
SALL2 spalt-like transcription factor 2 -2.21025
AIG1 androgen-induced 1 -2.2097
NLGN4X neuroligin 4, X-linked -2.20945
CA3 carbonic anhydrase III -2.20935
MC4R melanocortin 4 receptor -2.20765
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.20485
USP53 ubiquitin specific peptidase 53 -2.2015
ZIM2 zinc finger, imprinted 2 -2.20035
MYO10 myosin X -2.1972
SMAD5 SMAD family member 5 -2.19362
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -2.19217
TFDP1 transcription factor Dp-1 -2.1897
NLGN4Y neuroligin 4, Y-linked -2.18945
HMGN1 high mobility group nucleosome binding domain 1 -2.18935
CDKN3 cyclin-dependent kinase inhibitor 3 -2.1889
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.1885
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.18765
PRUNE1 prune exopolyphosphatase 1 -2.1859
COL1A2 collagen, type I, alpha 2 -2.18348
IFNA16 interferon, alpha 16 -2.18227
LOC102724594 splicing factor U2AF 35 kDa subunit -2.18225
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.18055
PARPBP PARP1 binding protein -2.17965
TMEM255A transmembrane protein 255A -2.17755
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.17455
TRDN triadin -2.1724
TARDBP TAR DNA binding protein -2.17235
UXT ubiquitously-expressed, prefoldin-like chaperone -2.17122
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.1709
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 -2.1702
RPL19 ribosomal protein L19 -2.169
GPR63 G protein-coupled receptor 63 -2.16745
PCDHB8 protocadherin beta 8 -2.16515
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -2.163
RAB15 RAB15, member RAS oncogene family -2.16295
FOXH1 forkhead box H1 -2.1627
ZNF552 zinc finger protein 552 -2.1613
KIF4A kinesin family member 4A -2.15945
PRMT1 protein arginine methyltransferase 1 -2.1575
NUP88 nucleoporin 88kDa -2.15733
CRELD2 cysteine-rich with EGF-like domains 2 -2.15125
PDF peptide deformylase (mitochondrial) -2.1468
PCDHGA3 protocadherin gamma subfamily A, 3 -2.14625
LMAN2L lectin, mannose-binding 2-like -2.14605
RYR3 ryanodine receptor 3 -2.14495
LGI1 leucine-rich, glioma inactivated 1 -2.1434
CEP70 centrosomal protein 70kDa -2.1432
MLEC malectin -2.14195
CNTNAP2 contactin associated protein-like 2 -2.14141
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.14075
GAP43 growth associated protein 43 -2.1407
DOK5 docking protein 5 -2.14065
PMFBP1 polyamine modulated factor 1 binding protein 1 -2.14065
GPR75 G protein-coupled receptor 75 -2.1402
FN3K fructosamine 3 kinase -2.14005
PLCH1 phospholipase C, eta 1 -2.13915
RNF32 ring finger protein 32 -2.13865
GAN gigaxonin -2.13485
CCNE1 cyclin E1 -2.13425
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.13342
MYBPC2 myosin binding protein C, fast type -2.13285
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.13265
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.1323
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.1323
CCDC33 coiled-coil domain containing 33 -2.12995
ZNF232 zinc finger protein 232 -2.1256
BCO1 beta-carotene oxygenase 1 -2.12185
CTNNBL1 catenin, beta like 1 -2.1216
ATF5 activating transcription factor 5 -2.12147
RIBC2 RIB43A domain with coiled-coils 2 -2.12055
ZP2 zona pellucida glycoprotein 2 (sperm receptor) -2.1193
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.1186
PID1 phosphotyrosine interaction domain containing 1 -2.11685
ACTL7A actin-like 7A -2.1164
CTXND1 cortexin domain containing 1 -2.11632
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.10715
VEGFD vascular endothelial growth factor D -2.1065
TAAR2 trace amine associated receptor 2 -2.1062
DIAPH3 diaphanous-related formin 3 -2.1054
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.1019
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide -2.1012
SYNJ2BP synaptojanin 2 binding protein -2.09695
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -2.09654
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -2.09643
GRM5 glutamate receptor, metabotropic 5 -2.09477
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.09445
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -2.09435
AGBL2 ATP/GTP binding protein-like 2 -2.09115
MTCH2 mitochondrial carrier 2 -2.0906
HIGD1B HIG1 hypoxia inducible domain family, member 1B -2.08585
RPL23A ribosomal protein L23a -2.0841
RNF130 ring finger protein 130 -2.08375
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -2.08345
RGN regucalcin -2.08325
KLF8 Kruppel-like factor 8 -2.0832
CEP112 centrosomal protein 112kDa -2.08285
MMP25 matrix metallopeptidase 25 -2.0821
RIC3 RIC3 acetylcholine receptor chaperone -2.0801
GPC5 glypican 5 -2.0796
FBF1 Fas (TNFRSF6) binding factor 1 -2.0787
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 -2.0779
GDF3 growth differentiation factor 3 -2.0768
DBF4 DBF4 zinc finger -2.07615
KLHL41 kelch-like family member 41 -2.07325
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.0723
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 -2.07203
EYA3 EYA transcriptional coactivator and phosphatase 3 -2.07165
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.0693
COMMD9 COMM domain containing 9 -2.06905
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.067
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.06593
DPEP2 dipeptidase 2 -2.06505
ENTREP2 endosomal transmembrane epsin interactor 2 -2.06495
TLL1 tolloid-like 1 -2.0647
COQ3 coenzyme Q3 methyltransferase -2.06465
ZNF214 zinc finger protein 214 -2.06465
TRIP13 thyroid hormone receptor interactor 13 -2.0637
RGSL1 regulator of G-protein signaling like 1 -2.06355
CCDC121 coiled-coil domain containing 121 -2.0635
SENP7 SUMO1/sentrin specific peptidase 7 -2.06315
CDCA4 cell division cycle associated 4 -2.06295
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.0625
SOX30 SRY (sex determining region Y)-box 30 -2.0623
SLC17A2 solute carrier family 17, member 2 -2.06145
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -2.06095
CNTN5 contactin 5 -2.0603
USH2A Usher syndrome 2A (autosomal recessive, mild) -2.0582
GRIA1 glutamate receptor, ionotropic, AMPA 1 -2.0579
RPA4 replication protein A4, 30kDa -2.0535
OR7A17 olfactory receptor, family 7, subfamily A, member 17 -2.053
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -2.05175
TMOD1 tropomodulin 1 -2.05148
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.05107
MYOZ3 myozenin 3 -2.0504
ELP4 elongator acetyltransferase complex subunit 4 -2.04995
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.04955
ELOVL2 ELOVL fatty acid elongase 2 -2.0477
PNPLA3 patatin-like phospholipase domain containing 3 -2.04735
LDHAL6B lactate dehydrogenase A-like 6B -2.04615
MYBPH myosin binding protein H -2.0458
MLF1 myeloid leukemia factor 1 -2.04505
MYRIP myosin VIIA and Rab interacting protein -2.0443
CA10 carbonic anhydrase X -2.0441
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.044
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.04305
MTNAP1 mitochondrial nucleoid associated protein 1 -2.04115
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.03995
IFITM3 interferon induced transmembrane protein 3 -2.03285
RIDA reactive intermediate imine deaminase A homolog -2.03265
DHCR7 7-dehydrocholesterol reductase -2.03262
SCG2 secretogranin II -2.03245
RNFT2 ring finger protein, transmembrane 2 -2.02978
SMPX small muscle protein, X-linked -2.02975
PGRMC1 progesterone receptor membrane component 1 -2.02935
TMEM35A transmembrane protein 35A -2.0271
ZNF480 zinc finger protein 480 -2.0258
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -2.02575
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.02505
FAM117A family with sequence similarity 117, member A -2.02445
TMEM161A transmembrane protein 161A -2.02355
PPP1R3A protein phosphatase 1, regulatory subunit 3A -2.0226
EIF3G eukaryotic translation initiation factor 3, subunit G -2.02255
WRNIP1 Werner helicase interacting protein 1 -2.02045
ECH1 enoyl CoA hydratase 1, peroxisomal -2.0203
AKR1D1 aldo-keto reductase family 1, member D1 -2.0184
CNGA3 cyclic nucleotide gated channel alpha 3 -2.0168
ZNF528 zinc finger protein 528 -2.01445
IFNA7 interferon, alpha 7 -2.01275
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.0117
RPGRIP1L RPGRIP1-like -2.01165
RBMXL2 RNA binding motif protein, X-linked-like 2 -2.0108
SPON1 spondin 1, extracellular matrix protein -2.00634
GLRX5 glutaredoxin 5 -2.0056
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.0041
MB myoglobin -2.00285
MYH7 myosin, heavy chain 7, cardiac muscle, beta -2.00245
SPA17 sperm autoantigenic protein 17 -2.0014
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 -2.0002