CRCGN008_HEPG2_24H:I04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 2.59 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

473 genes differentially expressed following the CRCGN008_HEPG2_24H:I04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
CNPY3 canopy FGF signaling regulator 3 7.47455
LSR lipolysis stimulated lipoprotein receptor 7.41355
INPP1 inositol polyphosphate-1-phosphatase 6.8934
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 6.8183
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 6.76865
IER3 immediate early response 3 6.71735
KIFBP kinesin family binding protein 6.2928
GLRX glutaredoxin (thioltransferase) 5.63145
ACOT9 acyl-CoA thioesterase 9 5.5302
TIMP2 TIMP metallopeptidase inhibitor 2 5.2792
PPARG peroxisome proliferator-activated receptor gamma 5.26075
LCN2 lipocalin 2 5.2473
EGF epidermal growth factor 5.1476
CXCL2 chemokine (C-X-C motif) ligand 2 5.1263
CDCA4 cell division cycle associated 4 5.0761
IGFBP3 insulin-like growth factor binding protein 3 5.05965
NOTCH1 notch 1 4.87765
CAPN1 calpain 1, (mu/I) large subunit 4.7566
SPAG7 sperm associated antigen 7 4.67135
SQOR sulfide quinone oxidoreductase 4.596
MVP major vault protein 4.4262
FZD7 frizzled class receptor 7 4.41353
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.37743
S100A4 S100 calcium binding protein A4 4.3735
LGALS8 lectin, galactoside-binding, soluble, 8 4.34479
DYNLT3 dynein, light chain, Tctex-type 3 4.33555
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.3307
CCP110 centriolar coiled coil protein 110kDa 4.22215
NPC1 Niemann-Pick disease, type C1 4.2031
LAP3 leucine aminopeptidase 3 4.1816
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.16668
ARL4C ADP-ribosylation factor-like 4C 4.16642
CHMP6 charged multivesicular body protein 6 4.1435
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.069
HOXA10 homeobox A10 3.9894
GTPBP8 GTP-binding protein 8 (putative) 3.983
SLC35F2 solute carrier family 35, member F2 3.97205
LOC124907782 dual specificity protein phosphatase 22 3.83255
KHDC4 KH domain containing 4, pre-mRNA splicing factor 3.8037
DUSP4 dual specificity phosphatase 4 3.78895
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.77853
SOX4 SRY (sex determining region Y)-box 4 3.53813
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 3.51133
GHR growth hormone receptor 3.5087
PXDC1 PX domain containing 1 3.4517
DUSP6 dual specificity phosphatase 6 3.43668
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.4302
GRB10 growth factor receptor-bound protein 10 3.3533
BLVRA biliverdin reductase A 3.294
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.2937
VAT1 vesicle amine transport 1 3.22455
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 3.17385
TWF2 twinfilin actin binding protein 2 3.17215
FAT1 FAT atypical cadherin 1 3.1266
VGLL4 vestigial-like family member 4 3.1229
PKN1 protein kinase N1 3.11087
CORO1A coronin, actin binding protein, 1A 3.11045
TRIB1 tribbles pseudokinase 1 3.0893
WDTC1 WD and tetratricopeptide repeats 1 3.07588
MUC1 mucin 1, cell surface associated 3.06647
BCOR BCL6 corepressor 3.03265
RALB v-ral simian leukemia viral oncogene homolog B 2.99213
CUL4B cullin 4B 2.9758
ANGPTL4 angiopoietin-like 4 2.9716
KLHL9 kelch-like family member 9 2.9601
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.9601
PRKCD protein kinase C, delta 2.93465
PEX11A peroxisomal biogenesis factor 11 alpha 2.92977
MAP7 microtubule-associated protein 7 2.91847
CLTB clathrin, light chain B 2.91706
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.90135
CALCOCO1 calcium binding and coiled-coil domain 1 2.8623
ITFG1 integrin alpha FG-GAP repeat containing 1 2.85785
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.82388
BAZ2B bromodomain adjacent to zinc finger domain, 2B 2.81755
SERINC1 serine incorporator 1 2.8106
IGF2R insulin-like growth factor 2 receptor 2.7779
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.76227
SQSTM1 sequestosome 1 2.75988
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.75945
GPER1 G protein-coupled estrogen receptor 1 2.75595
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.7535
ECHDC2 enoyl CoA hydratase domain containing 2 2.7114
BRD9 bromodomain containing 9 2.711
KDM5A lysine (K)-specific demethylase 5A 2.68942
MICALL1 MICAL-like 1 2.65907
IFT20 intraflagellar transport 20 2.6483
KDM3A lysine (K)-specific demethylase 3A 2.6446
DNM1L dynamin 1-like 2.6147
ATP9A ATPase, class II, type 9A 2.6114
KEAP1 kelch-like ECH-associated protein 1 2.5992
NUDC nudC nuclear distribution protein 2.59908
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.5688
ANXA1 annexin A1 2.5526
EDN1 endothelin 1 2.54295
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 2.54093
S100A13 S100 calcium binding protein A13 2.53242
SIRT3 sirtuin 3 2.52538
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.5222
ZSCAN9 zinc finger and SCAN domain containing 9 2.517
PCDHGA5 protocadherin gamma subfamily A, 5 2.5138
CSNK1E casein kinase 1, epsilon 2.5118
NPDC1 neural proliferation, differentiation and control, 1 2.5111
SKAP2 src kinase associated phosphoprotein 2 2.50388
VAMP8 vesicle-associated membrane protein 8 2.50185
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.5015
HSPA1A heat shock 70kDa protein 1A 2.49135
TLE5 TLE family member 5, transcriptional modulator 2.48725
KRT19 keratin 19, type I 2.4782
GPATCH8 G patch domain containing 8 2.47438
DCK deoxycytidine kinase 2.46805
ZNF84 zinc finger protein 84 2.4673
CRY2 cryptochrome circadian clock 2 2.46725
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.467
CYCS cytochrome c, somatic 2.46035
SPRY2 sprouty homolog 2 (Drosophila) 2.457
TACC2 transforming, acidic coiled-coil containing protein 2 2.44275
GOLT1B golgi transport 1B 2.43315
CDC25B cell division cycle 25B 2.41275
PNKP polynucleotide kinase 3'-phosphatase 2.4091
TXNIP thioredoxin interacting protein 2.40617
XPC xeroderma pigmentosum, complementation group C 2.3993
CD40 CD40 molecule, TNF receptor superfamily member 5 2.39684
WHRN whirlin 2.39365
E2F2 E2F transcription factor 2 2.3803
EPS8L2 EPS8-like 2 2.3673
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.36702
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.364
INPP5K inositol polyphosphate-5-phosphatase K 2.36137
FIG4 FIG4 phosphoinositide 5-phosphatase 2.34745
EGR1 early growth response 1 2.33757
ZNF195 zinc finger protein 195 2.33635
RBP4 retinol binding protein 4, plasma 2.33205
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.3299
TMSB4X thymosin beta 4, X-linked 2.3183
EFHC1 EF-hand domain (C-terminal) containing 1 2.3176
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 2.315
CD58 CD58 molecule 2.31428
ABHD5 abhydrolase domain containing 5 2.30843
KRT15 keratin 15, type I 2.2981
HP1BP3 heterochromatin protein 1, binding protein 3 2.2936
NT5M 5',3'-nucleotidase, mitochondrial 2.28865
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.2881
EPCAM epithelial cell adhesion molecule 2.28735
ZNF136 zinc finger protein 136 2.2835
IL7R interleukin 7 receptor 2.2785
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.2771
CASC3 cancer susceptibility candidate 3 2.2756
RBMX2 RNA binding motif protein, X-linked 2 2.2754
RHOF ras homolog family member F (in filopodia) 2.2714
CST2 cystatin SA 2.2713
PTCRA pre T-cell antigen receptor alpha 2.2689
TCL1A T-cell leukemia/lymphoma 1A 2.2627
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.25423
ARID5A AT rich interactive domain 5A (MRF1-like) 2.24775
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 2.24542
PRSS16 protease, serine, 16 (thymus) 2.2412
CST1 cystatin SN 2.2206
CRY1 cryptochrome circadian clock 1 2.22035
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.2165
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.21645
ZNF589 zinc finger protein 589 2.21473
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 2.2122
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough 2.20587
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) 2.20522
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 2.205
SUN2 Sad1 and UNC84 domain containing 2 2.1995
MBNL2 muscleblind-like splicing regulator 2 2.19385
P3H3 prolyl 3-hydroxylase 3 2.19355
ADGRE5 adhesion G protein-coupled receptor E5 2.18695
AAMDC adipogenesis associated, Mth938 domain containing 2.17535
SLCO4C1 solute carrier organic anion transporter family, member 4C1 2.1646
BICRAL BICRA like chromatin remodeling complex associated protein 2.1637
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.16085
DNM1 dynamin 1 2.1602
LDHA lactate dehydrogenase A 2.1538
BCL2L1 BCL2-like 1 2.13893
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.13885
ZFAND5 zinc finger, AN1-type domain 5 2.13398
CDK7 cyclin-dependent kinase 7 2.13315
CENPC centromere protein C 2.1306
PARP8 poly (ADP-ribose) polymerase family, member 8 2.12635
S100A6 S100 calcium binding protein A6 2.12585
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.12337
DUSP8 dual specificity phosphatase 8 2.121
KLHL24 kelch-like family member 24 2.11657
WDR7 WD repeat domain 7 2.1157
OPTN optineurin 2.11273
ARL17B ADP-ribosylation factor-like 17B 2.1098
ITGB5 integrin, beta 5 2.0924
AXIN1 axin 1 2.09065
MDM4 MDM4, p53 regulator 2.08035
WNT11 wingless-type MMTV integration site family, member 11 2.07425
CEL carboxyl ester lipase 2.07055
MED15 mediator complex subunit 15 2.0684
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.06685
CD59 CD59 molecule, complement regulatory protein 2.06273
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.05945
RTN4 reticulon 4 2.0565
CD19 CD19 molecule 2.0562
TMC5 transmembrane channel-like 5 2.0557
TRAK1 trafficking protein, kinesin binding 1 2.05347
TRIOBP TRIO and F-actin binding protein 2.04828
NPIPB4 nuclear pore complex interacting protein family, member B4 2.04265
TMED1 transmembrane emp24 protein transport domain containing 1 2.0401
CD24 CD24 molecule 2.03637
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.03475
LSG1 large 60S subunit nuclear export GTPase 1 2.03355
SIGLEC15 sialic acid binding Ig-like lectin 15 2.03155
DEAF1 DEAF1 transcription factor 2.02545
LOC127933115 uncharacterized LOC127933115 2.02215
BTG2 BTG family, member 2 2.02205
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.0211
ZNF783 zinc finger family member 783 2.01657
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.01455
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.00825
AGBL5 ATP/GTP binding protein-like 5 2.0028

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
NT5DC2 5'-nucleotidase domain containing 2 -10.0
AURKB aurora kinase B -7.32995
PLK1 polo-like kinase 1 -7.32265
ISOC1 isochorismatase domain containing 1 -7.2032
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -6.9331
ANKRD10 ankyrin repeat domain 10 -6.80845
PSRC1 proline/serine-rich coiled-coil 1 -6.60885
TMEM109 transmembrane protein 109 -6.476
FGFR4 fibroblast growth factor receptor 4 -6.3228
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -6.1514
ARID5B AT rich interactive domain 5B (MRF1-like) -5.96475
OXA1L oxidase (cytochrome c) assembly 1-like -5.8284
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -5.61193
CCNB1 cyclin B1 -5.52835
CD320 CD320 molecule -5.47195
TCTN1 tectonic family member 1 -5.39625
B4GAT1 beta-1,4-glucuronyltransferase 1 -5.3705
ICAM3 intercellular adhesion molecule 3 -5.30085
FASTKD5 FAST kinase domains 5 -5.26835
CCNA2 cyclin A2 -5.21147
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.12385
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.094
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0495
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.0061
LAGE3 L antigen family, member 3 -4.9336
HADH hydroxyacyl-CoA dehydrogenase -4.77452
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.67882
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -4.6257
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -4.511
PCNA proliferating cell nuclear antigen -4.50795
MRPS2 mitochondrial ribosomal protein S2 -4.4014
RPP38 ribonuclease P/MRP 38kDa subunit -4.37215
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -4.35248
TCERG1 transcription elongation regulator 1 -4.29665
LDHD lactate dehydrogenase D -4.26295
NIT1 nitrilase 1 -4.25705
SH3D19 SH3 domain containing 19 -4.23725
RXYLT1 ribitol xylosyltransferase 1 -4.18385
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -4.1377
PLA2G15 phospholipase A2, group XV -4.11205
DDIT4 DNA-damage-inducible transcript 4 -4.09745
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.0732
NR2F6 nuclear receptor subfamily 2, group F, member 6 -4.04332
NLRP2B NLR family pyrin domain containing 2B -3.9962
RUVBL1 RuvB-like AAA ATPase 1 -3.97165
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.8705
TOP2A topoisomerase (DNA) II alpha 170kDa -3.81472
INTS3 integrator complex subunit 3 -3.7632
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.60355
RBM15B RNA binding motif protein 15B -3.52185
NENF neudesin neurotrophic factor -3.5175
CNOT7 CCR4-NOT transcription complex, subunit 7 -3.51125
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.5046
HEBP1 heme binding protein 1 -3.4508
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -3.43495
LBR lamin B receptor -3.42055
LYRM1 LYR motif containing 1 -3.3929
MELK maternal embryonic leucine zipper kinase -3.33855
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.3244
SOAT2 sterol O-acyltransferase 2 -3.30492
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.29735
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.27465
RPIA ribose 5-phosphate isomerase A -3.22745
ENTR1 endosome associated trafficking regulator 1 -3.20135
CDKN3 cyclin-dependent kinase inhibitor 3 -3.18095
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -3.1609
IL36G interleukin 36, gamma -3.14815
CDCA3 cell division cycle associated 3 -3.13135
ELAVL1 ELAV like RNA binding protein 1 -3.1217
THAP11 THAP domain containing 11 -3.1128
NEIL3 nei endonuclease VIII-like 3 (E. coli) -3.09125
BIRC5 baculoviral IAP repeat containing 5 -3.0839
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.0515
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.0484
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -3.04225
EXOSC8 exosome component 8 -2.99355
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.96745
ERCC6L excision repair cross-complementation group 6-like -2.9633
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.96065
TGFB3 transforming growth factor, beta 3 -2.9532
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.93532
CETN3 centrin, EF-hand protein, 3 -2.93345
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.9174
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -2.9165
PYCR1 pyrroline-5-carboxylate reductase 1 -2.8777
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.87552
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.8751
NRIP1 nuclear receptor interacting protein 1 -2.874
PECR peroxisomal trans-2-enoyl-CoA reductase -2.87235
ALDOC aldolase C, fructose-bisphosphate -2.83985
TMEM177 transmembrane protein 177 -2.81345
PCDH17 protocadherin 17 -2.80455
DBF4 DBF4 zinc finger -2.8037
UBE2C ubiquitin-conjugating enzyme E2C -2.8034
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.80243
FFAR2 free fatty acid receptor 2 -2.78475
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 -2.7375
HEATR3 HEAT repeat containing 3 -2.73595
SYCP1 synaptonemal complex protein 1 -2.73222
TBC1D31 TBC1 domain family, member 31 -2.71555
GTF2A2 general transcription factor IIA, 2, 12kDa -2.7018
TEAD4 TEA domain family member 4 -2.69447
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -2.6756
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.6754
MRPS33 mitochondrial ribosomal protein S33 -2.6742
PRUNE1 prune exopolyphosphatase 1 -2.66908
MRPL12 mitochondrial ribosomal protein L12 -2.6655
POLR1G RNA polymerase I subunit G -2.654
SPDL1 spindle apparatus coiled-coil protein 1 -2.6445
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.63895
ENAH enabled homolog (Drosophila) -2.6319
THEM6 thioesterase superfamily member 6 -2.62625
COQ9 coenzyme Q9 -2.6061
HMG20B high mobility group 20B -2.6057
UNC5C unc-5 homolog C (C. elegans) -2.602
RABEPK Rab9 effector protein with kelch motifs -2.59955
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.59775
MLEC malectin -2.5962
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.59355
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.5921
ADGRB3 adhesion G protein-coupled receptor B3 -2.58495
LYSET lysosomal enzyme trafficking factor -2.5805
SDF2L1 stromal cell-derived factor 2-like 1 -2.5543
PCID2 PCI domain containing 2 -2.53825
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.53415
PNPLA3 patatin-like phospholipase domain containing 3 -2.5335
MYH10 myosin, heavy chain 10, non-muscle -2.52332
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.5144
OIP5 Opa interacting protein 5 -2.51355
ATXN2 ataxin 2 -2.503
MYCBP MYC binding protein -2.50058
MAB21L2 mab-21-like 2 (C. elegans) -2.49625
PPP1R10 protein phosphatase 1, regulatory subunit 10 -2.4934
PIPOX pipecolic acid oxidase -2.4923
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.4862
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.48315
PDF peptide deformylase (mitochondrial) -2.46535
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.46225
MRPL34 mitochondrial ribosomal protein L34 -2.45945
HNMT histamine N-methyltransferase -2.44865
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.4483
FANCG Fanconi anemia, complementation group G -2.44575
DGKH diacylglycerol kinase, eta -2.44525
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.44375
UBE3C ubiquitin protein ligase E3C -2.4343
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.41315
GAA glucosidase, alpha; acid -2.4121
ECH1 enoyl CoA hydratase 1, peroxisomal -2.40845
SMG8 SMG8 nonsense mediated mRNA decay factor -2.40735
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -2.392
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.38795
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.37985
MYO10 myosin X -2.3684
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.3542
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.35348
KRCC1 lysine-rich coiled-coil 1 -2.35055
CEP55 centrosomal protein 55kDa -2.3478
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.34308
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.3314
ARL5A ADP-ribosylation factor-like 5A -2.3294
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -2.32025
ZDHHC6 zinc finger, DHHC-type containing 6 -2.32005
AURKA aurora kinase A -2.3176
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.31665
MKKS McKusick-Kaufman syndrome -2.29895
DHCR7 7-dehydrocholesterol reductase -2.2936
CCNF cyclin F -2.28792
PGRMC1 progesterone receptor membrane component 1 -2.28463
ZSCAN5A zinc finger and SCAN domain containing 5A -2.27905
GSTM2 glutathione S-transferase mu 2 (muscle) -2.277
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.26835
HMOX2 heme oxygenase 2 -2.26775
FGD1 FYVE, RhoGEF and PH domain containing 1 -2.26185
PARPBP PARP1 binding protein -2.2611
HMGN1 high mobility group nucleosome binding domain 1 -2.25875
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.2572
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.2561
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.2529
SLC38A6 solute carrier family 38, member 6 -2.2486
CBR1 carbonyl reductase 1 -2.2416
OSBPL11 oxysterol binding protein-like 11 -2.238
GATA4 GATA binding protein 4 -2.2349
NCAPD2 non-SMC condensin I complex, subunit D2 -2.23465
DPH5 diphthamide biosynthesis 5 -2.23452
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.23415
CCL7 chemokine (C-C motif) ligand 7 -2.2333
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -2.23055
TUBB6 tubulin, beta 6 class V -2.2163
LMNB1 lamin B1 -2.20005
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.19945
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.1973
CENPS-CORT CENPS-CORT readthrough -2.19165
MRPL11 mitochondrial ribosomal protein L11 -2.18525
ARSF arylsulfatase F -2.18475
RIDA reactive intermediate imine deaminase A homolog -2.17815
PPA2 pyrophosphatase (inorganic) 2 -2.17705
FASTKD3 FAST kinase domains 3 -2.1718
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.17065
IL36RN interleukin 36 receptor antagonist -2.15435
PFAS phosphoribosylformylglycinamidine synthase -2.15025
CLCN5 chloride channel, voltage-sensitive 5 -2.1478
PNLIPRP2 pancreatic lipase-related protein 2 -2.14505
RPN1 ribophorin I -2.14495
HMG20A high mobility group 20A -2.14435
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.14065
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.13645
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.12955
COL3A1 collagen, type III, alpha 1 -2.12412
HMGB2 high mobility group box 2 -2.12155
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -2.12118
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.11995
HSPA14 heat shock 70kDa protein 14 -2.1148
RACGAP1 Rac GTPase activating protein 1 -2.11285
MRPL35 mitochondrial ribosomal protein L35 -2.10795
CDK4 cyclin-dependent kinase 4 -2.1052
TRIM14 tripartite motif containing 14 -2.09951
PIMREG PICALM interacting mitotic regulator -2.0972
HSDL2 hydroxysteroid dehydrogenase like 2 -2.09648
NUP62 nucleoporin 62kDa -2.09307
TSEN34 TSEN34 tRNA splicing endonuclease subunit -2.0926
FABP1 fatty acid binding protein 1, liver -2.0895
CDK1 cyclin-dependent kinase 1 -2.08258
PUS1 pseudouridylate synthase 1 -2.0822
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -2.0812
PTCD1 pentatricopeptide repeat domain 1 -2.081
SMAD5 SMAD family member 5 -2.07982
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.07945
ZMIZ1 zinc finger, MIZ-type containing 1 -2.0789
DEFA5 defensin, alpha 5, Paneth cell-specific -2.0768
NGRN neugrin, neurite outgrowth associated -2.0753
RNF139 ring finger protein 139 -2.07255
FPGT fucose-1-phosphate guanylyltransferase -2.06785
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.0676
PDCD5 programmed cell death 5 -2.05685
NUP37 nucleoporin 37kDa -2.0559
WDR12 WD repeat domain 12 -2.052
NECTIN3 nectin cell adhesion molecule 3 -2.052
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -2.05195
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.04935
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.04765
CRELD2 cysteine-rich with EGF-like domains 2 -2.04195
MRPL16 mitochondrial ribosomal protein L16 -2.0371
PITX2 paired-like homeodomain 2 -2.0333
PLCE1 phospholipase C, epsilon 1 -2.02752
KIF18B kinesin family member 18B -2.02535
TFDP1 transcription factor Dp-1 -2.02165
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.0166
NXT1 nuclear transport factor 2-like export factor 1 -2.0158
PTDSS1 phosphatidylserine synthase 1 -2.01305
SCGB1D1 secretoglobin, family 1D, member 1 -2.00627
BCHE butyrylcholinesterase -2.0058
PMM2 phosphomannomutase 2 -2.0018
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.0014