CRCGN008_HEPG2_24H:I07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dibutyl-2-oxohydrazine 21.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN008_HEPG2_24H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CBR3 carbonyl reductase 3 5.5895
GPATCH8 G patch domain containing 8 5.57302
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.51235
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.4709
BACE2 beta-site APP-cleaving enzyme 2 5.2056
CCL2 chemokine (C-C motif) ligand 2 5.15705
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.0
STK10 serine/threonine kinase 10 4.89987
EPHA3 EPH receptor A3 4.60373
ADRB2 adrenoceptor beta 2, surface 4.5507
MYLK myosin light chain kinase 4.2943
IDE insulin-degrading enzyme 4.27888
CDPF1 cysteine-rich, DPF motif domain containing 1 3.67105
EGF epidermal growth factor 3.63065
CCDC85B coiled-coil domain containing 85B 3.61745
HOXA10 homeobox A10 3.56608
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.38353
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.29355
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.03097
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.00715
TIAM1 T-cell lymphoma invasion and metastasis 1 2.84802
BPHL biphenyl hydrolase-like (serine hydrolase) 2.8376
FLG filaggrin 2.7324
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.5636
CYCS cytochrome c, somatic 2.5241
NMU neuromedin U 2.5157
METRN meteorin, glial cell differentiation regulator 2.49095
LORICRIN loricrin cornified envelope precursor protein 2.46855
LHFPL6 LHFPL tetraspan subfamily member 6 2.46475
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.4601
LRRC40 leucine rich repeat containing 40 2.4454
CCN3 cellular communication network factor 3 2.39998
ZNF589 zinc finger protein 589 2.36168
OMD osteomodulin 2.34555
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.31465
LCE2B late cornified envelope 2B 2.3141
TASOR2 transcription activation suppressor family member 2 2.29015
HSPA1A heat shock 70kDa protein 1A 2.27065
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 2.27047
HMG20A high mobility group 20A 2.26565
GARRE1 granule associated Rac and RHOG effector 1 2.2597
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.2584
MMP1 matrix metallopeptidase 1 2.25542
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.24105
BIN3 bridging integrator 3 2.2349
HYAL4 hyaluronoglucosaminidase 4 2.2215
PAQR3 progestin and adipoQ receptor family member III 2.215
SEC61G Sec61 gamma subunit 2.1992
HOXA1 homeobox A1 2.192
PXMP4 peroxisomal membrane protein 4, 24kDa 2.1687
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.13245
ISG15 ISG15 ubiquitin-like modifier 2.11105
EXPH5 exophilin 5 2.10365
LOC122526780 uncharacterized LOC122526780 2.10285
FAM3C family with sequence similarity 3, member C 2.10145
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.0995
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.09445
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.07035
KRT2 keratin 2, type II 2.0553
RAB38 RAB38, member RAS oncogene family 2.05145
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.02305
HAL histidine ammonia-lyase 2.0225
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.021

decreased expression

Symbol Name Standardized Value
FBXL12 F-box and leucine-rich repeat protein 12 -7.23225
TRIB3 tribbles pseudokinase 3 -6.06165
ZMIZ1 zinc finger, MIZ-type containing 1 -4.97645
NT5DC2 5'-nucleotidase domain containing 2 -4.9652
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -4.85068
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.6333
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.59885
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.5436
CD320 CD320 molecule -4.4008
MAP7 microtubule-associated protein 7 -4.22742
FGFR4 fibroblast growth factor receptor 4 -4.21585
GNAS GNAS complex locus -4.15257
HEATR1 HEAT repeat containing 1 -3.95112
CCNB2 cyclin B2 -3.6793
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.333
ANKRD10 ankyrin repeat domain 10 -3.30705
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.28945
OXA1L oxidase (cytochrome c) assembly 1-like -3.27705
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.098
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.903
NRIP1 nuclear receptor interacting protein 1 -2.63305
CLIC4 chloride intracellular channel 4 -2.5029
RBM34 RNA binding motif protein 34 -2.47917
HSPA8 heat shock 70kDa protein 8 -2.39043
PDIA5 protein disulfide isomerase family A, member 5 -2.3702
CYTH2 cytohesin 2 -2.3525
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.3434
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.31175
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.2713
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.1828
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -2.1806
CERS2 ceramide synthase 2 -2.16675
TRAF5 TNF receptor-associated factor 5 -2.1648
NBPF3 neuroblastoma breakpoint family, member 3 -2.11605
PFDN2 prefoldin subunit 2 -2.11575
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.10585
GUK1 guanylate kinase 1 -2.09355
REXO5 RNA exonuclease 5 -2.0719
FNDC11 fibronectin type III domain containing 11 -2.0368
RAB22A RAB22A, member RAS oncogene family -2.03665
HSPH1 heat shock 105kDa/110kDa protein 1 -2.02712
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -2.0152