CRCGN008_HEPG2_24H:I10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dibutyl-2-oxohydrazine 2.69 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN008_HEPG2_24H:I10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 5.4503
LAGE3 L antigen family, member 3 5.3543
HLA-DMA major histocompatibility complex, class II, DM alpha 5.3541
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.1635
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0569
LOC122526780 uncharacterized LOC122526780 4.7415
CCL2 chemokine (C-C motif) ligand 2 4.5405
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.4575
AMDHD2 amidohydrolase domain containing 2 4.4392
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.346
MELK maternal embryonic leucine zipper kinase 4.1665
GPER1 G protein-coupled estrogen receptor 1 4.00602
SNAP25 synaptosomal-associated protein, 25kDa 3.98592
CDPF1 cysteine-rich, DPF motif domain containing 1 3.9549
CD40 CD40 molecule, TNF receptor superfamily member 5 3.75148
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.2124
LPO lactoperoxidase 3.2057
RXYLT1 ribitol xylosyltransferase 1 3.17373
MMP2 matrix metallopeptidase 2 3.10275
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.06652
LPAR2 lysophosphatidic acid receptor 2 2.9975
DHDDS dehydrodolichyl diphosphate synthase 2.88763
PRB3 proline-rich protein BstNI subfamily 3 2.87825
BIRC2 baculoviral IAP repeat containing 2 2.7916
HTN3 histatin 3 2.7776
MUC7 mucin 7, secreted 2.75675
TIAM1 T-cell lymphoma invasion and metastasis 1 2.72697
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 2.6914
PRB4 proline-rich protein BstNI subfamily 4 2.65245
JADE2 jade family PHD finger 2 2.64715
EGFL8 EGF-like-domain, multiple 8 2.60278
CXCR5 chemokine (C-X-C motif) receptor 5 2.54583
TXNL4B thioredoxin-like 4B 2.5412
LTB lymphotoxin beta (TNF superfamily, member 3) 2.5258
PRH1 proline-rich protein HaeIII subfamily 1 2.4865
AQP7 aquaporin 7 2.463
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.43016
KCNIP2 Kv channel interacting protein 2 2.3921
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.387
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.37415
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.36835
SMR3B submaxillary gland androgen regulated protein 3B 2.31267
PRB2 proline-rich protein BstNI subfamily 2 2.30652
SMR3A submaxillary gland androgen regulated protein 3A 2.2863
COL11A2 collagen, type XI, alpha 2 2.26405
PTCH2 patched 2 2.26375
CREB3L4 cAMP responsive element binding protein 3-like 4 2.252
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.17812
FICD FIC domain containing 2.17575
ACR acrosin 2.17395
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.16952
EFNB1 ephrin-B1 2.1665
MATN4 matrilin 4 2.15855
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.1561
PTPRN protein tyrosine phosphatase, receptor type, N 2.1432
CATSPERH catsper channel auxiliary subunit eta 2.1356
PTK2 protein tyrosine kinase 2 2.13105
RAB26 RAB26, member RAS oncogene family 2.0897
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.08945
HTN1 histatin 1 2.07845
TMEM243 transmembrane protein 243, mitochondrial 2.03725
BPHL biphenyl hydrolase-like (serine hydrolase) 2.03435
TNIP1 TNFAIP3 interacting protein 1 2.02865
SDK2 sidekick cell adhesion molecule 2 2.02625
AQP5 aquaporin 5 2.0234
MAST3 microtubule associated serine/threonine kinase 3 2.0172
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.01355
CA7 carbonic anhydrase VII 2.0049
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.0049
CIDEA cell death-inducing DFFA-like effector a 2.0043

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.5952
CDC20 cell division cycle 20 -5.67995
INPP1 inositol polyphosphate-1-phosphatase -5.0612
ADI1 acireductone dioxygenase 1 -4.9508
VAT1 vesicle amine transport 1 -4.93225
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7749
MRPS2 mitochondrial ribosomal protein S2 -4.68325
ZMIZ1 zinc finger, MIZ-type containing 1 -4.16595
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.0629
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.8996
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.707
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.35225
FHL2 four and a half LIM domains 2 -2.996
OXA1L oxidase (cytochrome c) assembly 1-like -2.8633
USP22 ubiquitin specific peptidase 22 -2.61165
HDAC5 histone deacetylase 5 -2.5878
SCAND1 SCAN domain containing 1 -2.58085
PROS1 protein S (alpha) -2.57415
APOE apolipoprotein E -2.40425
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.4032
CDC25B cell division cycle 25B -2.3498
LRP10 low density lipoprotein receptor-related protein 10 -2.3244
SLC35F2 solute carrier family 35, member F2 -2.25695
DCK deoxycytidine kinase -2.23555
FBXL12 F-box and leucine-rich repeat protein 12 -2.2335
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.22353
MYO18A myosin XVIIIA -2.2167
MRM3 mitochondrial rRNA methyltransferase 3 -2.1097
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.10845
GLOD4 glyoxalase domain containing 4 -2.1035
ZW10 zw10 kinetochore protein -2.0427
COG4 component of oligomeric golgi complex 4 -2.04155
TPST1 tyrosylprotein sulfotransferase 1 -2.0367
GHR growth hormone receptor -2.02965
DGKD diacylglycerol kinase, delta 130kDa -2.0039