CRCGN008_HEPG2_24H:I11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dibutyl-2-oxohydrazine 1.34 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

87 genes differentially expressed following the CRCGN008_HEPG2_24H:I11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.58105
EAPP E2F-associated phosphoprotein 5.41765
DYNLT3 dynein, light chain, Tctex-type 3 5.18115
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8736
PPARG peroxisome proliferator-activated receptor gamma 4.78685
GPER1 G protein-coupled estrogen receptor 1 4.36705
FZD7 frizzled class receptor 7 4.21352
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.0971
MBOAT7 membrane bound O-acyltransferase domain containing 7 3.5833
CHN1 chimerin 1 3.0953
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.0351
EGR1 early growth response 1 3.02498
PLSCR3 phospholipid scramblase 3 2.88215
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.7008
TXNL4B thioredoxin-like 4B 2.6547
CEMIP2 cell migration inducing hyaluronidase 2 2.6211
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 2.54852
RNF167 ring finger protein 167 2.4311
NLGN4X neuroligin 4, X-linked 2.4122
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.3927
ARSA arylsulfatase A 2.3678
ANO1 anoctamin 1, calcium activated chloride channel 2.2916
LIPF lipase, gastric 2.27355
CLEC5A C-type lectin domain family 5, member A 2.2584
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.2427
TLR4 toll-like receptor 4 2.21805
FPR2 formyl peptide receptor 2 2.212
FSD1 fibronectin type III and SPRY domain containing 1 2.21085
PSIP1 PC4 and SFRS1 interacting protein 1 2.20958
AXIN1 axin 1 2.199
WDTC1 WD and tetratricopeptide repeats 1 2.1916
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 2.18365
KAT6A K(lysine) acetyltransferase 6A 2.1706
KRT2 keratin 2, type II 2.16765
NPDC1 neural proliferation, differentiation and control, 1 2.16025
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.1446
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 2.1322
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.12935
MBIP MAP3K12 binding inhibitory protein 1 2.1225
CBLIF cobalamin binding intrinsic factor 2.101
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.09288
FFAR2 free fatty acid receptor 2 2.0741
FGL2 fibrinogen-like 2 2.05975
CLEC4A C-type lectin domain family 4, member A 2.0518
ZNF180 zinc finger protein 180 2.04615
RAP1GAP2 RAP1 GTPase activating protein 2 2.03345
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 2.0083
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B 2.0029
TLR1 toll-like receptor 1 2.00015

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCNB2 cyclin B2 -8.6272
SOAT2 sterol O-acyltransferase 2 -5.01113
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.9158
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.7136
TRIB3 tribbles pseudokinase 3 -4.66275
ZMIZ1 zinc finger, MIZ-type containing 1 -4.6556
PLK1 polo-like kinase 1 -4.64025
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.4361
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.1742
GNAS GNAS complex locus -4.15979
PRPF4 pre-mRNA processing factor 4 -3.7729
MTA1 metastasis associated 1 -3.72195
OXA1L oxidase (cytochrome c) assembly 1-like -3.12485
FBXL12 F-box and leucine-rich repeat protein 12 -2.9956
HSPA8 heat shock 70kDa protein 8 -2.9555
SNX11 sorting nexin 11 -2.91525
MACF1 microtubule-actin crosslinking factor 1 -2.91336
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.81917
NBPF19 neuroblastoma breakpoint family, member 19 -2.5998
TXNDC9 thioredoxin domain containing 9 -2.57658
WASHC4 WASH complex subunit 4 -2.53415
NRIP1 nuclear receptor interacting protein 1 -2.48078
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.4335
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.42295
RNF111 ring finger protein 111 -2.33685
IMMT inner membrane protein, mitochondrial -2.1387
NTAQ1 N-terminal glutamine amidase 1 -2.1356
NLRP4 NLR family, pyrin domain containing 4 -2.12545
ZNHIT3 zinc finger, HIT-type containing 3 -2.11685
RARS1 arginyl-tRNA synthetase 1 -2.10885
TRIP4 thyroid hormone receptor interactor 4 -2.08085
NGF nerve growth factor (beta polypeptide) -2.0755
CD58 CD58 molecule -2.05417
NBPF10 neuroblastoma breakpoint family, member 10 -2.0482
FGF17 fibroblast growth factor 17 -2.0131
ZBTB5 zinc finger and BTB domain containing 5 -2.0092
FOXC1 forkhead box C1 -2.0081