CRCGN008_HEPG2_24H:I12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dibutyl-2-oxohydrazine 0.67 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

217 genes differentially expressed following the CRCGN008_HEPG2_24H:I12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 10.0
KCNK1 potassium channel, two pore domain subfamily K, member 1 7.61303
DYNLT3 dynein, light chain, Tctex-type 3 6.66825
CCL2 chemokine (C-C motif) ligand 2 6.6244
MSRA methionine sulfoxide reductase A 5.9822
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 5.63145
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.47165
TBPL1 TBP-like 1 5.2846
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 5.2659
CARMIL1 capping protein regulator and myosin 1 linker 1 5.03325
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.76245
ADRB2 adrenoceptor beta 2, surface 4.72055
EPHA3 EPH receptor A3 4.69502
MMP2 matrix metallopeptidase 2 4.6837
HLA-DMA major histocompatibility complex, class II, DM alpha 4.6076
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.57455
CSK c-src tyrosine kinase 4.48185
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.47835
CXCR4 chemokine (C-X-C motif) receptor 4 4.46382
CDPF1 cysteine-rich, DPF motif domain containing 1 4.27545
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.189
CHN1 chimerin 1 3.94295
HLA-DRA major histocompatibility complex, class II, DR alpha 3.91315
DENND2D DENN/MADD domain containing 2D 3.86775
H2BC12 H2B clustered histone 12 3.86315
MOK MOK protein kinase 3.8136
PRKCH protein kinase C, eta 3.7462
CXCL2 chemokine (C-X-C motif) ligand 2 3.68395
VGLL4 vestigial-like family member 4 3.59688
ZNF589 zinc finger protein 589 3.5712
FZD7 frizzled class receptor 7 3.4494
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.43508
SSBP2 single-stranded DNA binding protein 2 3.38083
GSTZ1 glutathione S-transferase zeta 1 3.36085
MAP7 microtubule-associated protein 7 3.26618
SAP30BP SAP30 binding protein 3.24675
PRKCD protein kinase C, delta 3.2351
TRIM13 tripartite motif containing 13 3.10705
CCDC85B coiled-coil domain containing 85B 3.10535
FCHO1 FCH domain only 1 2.9647
RBKS ribokinase 2.82548
FOXO3 forkhead box O3 2.81412
GPATCH8 G patch domain containing 8 2.76715
RBM34 RNA binding motif protein 34 2.72022
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.69948
JADE2 jade family PHD finger 2 2.63558
TNIP1 TNFAIP3 interacting protein 1 2.62435
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.58505
CERT1 ceramide transporter 1 2.48595
MCUR1 mitochondrial calcium uniporter regulator 1 2.47195
SOCS2 suppressor of cytokine signaling 2 2.47013
ELOVL6 ELOVL fatty acid elongase 6 2.44065
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.4293
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.42025
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.41045
H2BC5 H2B clustered histone 5 2.4069
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.40515
CRLF3 cytokine receptor-like factor 3 2.40465
CTSZ cathepsin Z 2.4025
MAMLD1 mastermind-like domain containing 1 2.38315
TMEM243 transmembrane protein 243, mitochondrial 2.3767
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.3637
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.3528
BAMBI BMP and activin membrane-bound inhibitor 2.3495
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.30215
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.2924
CD79B CD79b molecule, immunoglobulin-associated beta 2.2663
TXNL4B thioredoxin-like 4B 2.24965
ZNF165 zinc finger protein 165 2.2474
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2.2387
BAX BCL2-associated X protein 2.2267
HEBP1 heme binding protein 1 2.2211
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.20955
ARMC1 armadillo repeat containing 1 2.1816
MSN moesin 2.1815
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.15815
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.13042
RPL39L ribosomal protein L39-like 2.1298
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 2.1173
SNRPA small nuclear ribonucleoprotein polypeptide A 2.1082
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.1042
RNF139 ring finger protein 139 2.0901
LRP2 low density lipoprotein receptor-related protein 2 2.07885
FKBP11 FK506 binding protein 11, 19 kDa 2.06992
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.06945
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.0406
INSIG1 insulin induced gene 1 2.02592
CSRP2 cysteine and glycine-rich protein 2 2.01747
PDE5A phosphodiesterase 5A, cGMP-specific 2.00615

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.7596
SPAG4 sperm associated antigen 4 -6.11195
SLC35F2 solute carrier family 35, member F2 -5.6324
LDHD lactate dehydrogenase D -5.5742
NGRN neugrin, neurite outgrowth associated -5.51295
TRIB3 tribbles pseudokinase 3 -5.13145
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0
TWF2 twinfilin actin binding protein 2 -4.9917
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.96055
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.83595
CCNB2 cyclin B2 -4.764
ZW10 zw10 kinetochore protein -4.66865
ADI1 acireductone dioxygenase 1 -4.661
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.4588
EXT1 exostosin glycosyltransferase 1 -4.40685
PCNA proliferating cell nuclear antigen -4.2674
MVP major vault protein -4.21055
FAIM Fas apoptotic inhibitory molecule -4.02475
VDAC1 voltage-dependent anion channel 1 -3.93918
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.8177
TOR1A torsin family 1, member A (torsin A) -3.59787
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.55005
CAB39 calcium binding protein 39 -3.4123
ZNF586 zinc finger protein 586 -3.09875
RGS2 regulator of G-protein signaling 2 -3.01705
SCAND1 SCAN domain containing 1 -2.99695
TSKU tsukushi, small leucine rich proteoglycan -2.9684
NPFFR1 neuropeptide FF receptor 1 -2.94325
TBX2 T-box 2 -2.9308
EGF epidermal growth factor -2.8838
DUSP4 dual specificity phosphatase 4 -2.87865
CSNK1E casein kinase 1, epsilon -2.8676
SKIC2 SKI2 subunit of superkiller complex -2.84845
SIGLEC5 sialic acid binding Ig-like lectin 5 -2.8068
HMG20B high mobility group 20B -2.796
CORO7-PAM16 CORO7-PAM16 readthrough -2.7046
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -2.6983
IARS1 isoleucyl-tRNA synthetase 1 -2.66945
SNX11 sorting nexin 11 -2.64762
RPA4 replication protein A4, 30kDa -2.63745
GLOD4 glyoxalase domain containing 4 -2.61875
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.598
EBLN2 endogenous Bornavirus-like nucleoprotein 2 -2.59545
ZNF573 zinc finger protein 573 -2.5949
TMEM165 transmembrane protein 165 -2.59395
ADGRG3 adhesion G protein-coupled receptor G3 -2.5907
GNAS GNAS complex locus -2.55439
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.5393
SCIN scinderin -2.49445
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -2.47935
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.46065
CTSG cathepsin G -2.44835
MVB12B multivesicular body subunit 12B -2.44273
TGFB3 transforming growth factor, beta 3 -2.4396
GRK1 G protein-coupled receptor kinase 1 -2.42405
FBXL12 F-box and leucine-rich repeat protein 12 -2.41805
NIT2 nitrilase family, member 2 -2.4064
NFS1 NFS1 cysteine desulfurase -2.3943
RETN resistin -2.3936
LAGE3 L antigen family, member 3 -2.37375
EFNB1 ephrin-B1 -2.3661
STAP2 signal transducing adaptor family member 2 -2.3578
PROS1 protein S (alpha) -2.352
CLTB clathrin, light chain B -2.34838
ROM1 retinal outer segment membrane protein 1 -2.3411
CLEC16A C-type lectin domain family 16, member A -2.34005
TRIM25 tripartite motif containing 25 -2.32975
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 -2.3293
RAB5IF RAB5 interacting factor -2.31515
PALMD palmdelphin -2.3027
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 -2.27315
IL4R interleukin 4 receptor -2.2715
TENT2 terminal nucleotidyltransferase 2 -2.27085
MX2 MX dynamin-like GTPase 2 -2.257
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.25655
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.25545
RTP4 receptor (chemosensory) transporter protein 4 -2.23495
PIGT phosphatidylinositol glycan anchor biosynthesis, class T -2.2285
MACF1 microtubule-actin crosslinking factor 1 -2.22849
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.22605
CCP110 centriolar coiled coil protein 110kDa -2.22485
ANKRD10 ankyrin repeat domain 10 -2.22215
CD163L1 CD163 molecule-like 1 -2.22125
CATSPER2 cation channel, sperm associated 2 -2.2082
MX1 MX dynamin-like GTPase 1 -2.20695
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.19605
GRN granulin -2.19435
PCDHGA5 protocadherin gamma subfamily A, 5 -2.18965
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -2.16995
HELLS helicase, lymphoid-specific -2.16815
ACTL8 actin-like 8 -2.16515
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough -2.1598
HAND2 heart and neural crest derivatives expressed 2 -2.1597
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.15957
MMP26 matrix metallopeptidase 26 -2.15765
CD80 CD80 molecule -2.15315
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 -2.14628
HNMT histamine N-methyltransferase -2.1261
RPP40 ribonuclease P/MRP 40kDa subunit -2.1148
MYLK myosin light chain kinase -2.08785
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.08665
AOAH acyloxyacyl hydrolase (neutrophil) -2.0853
TMEM8B transmembrane protein 8B -2.07985
MAN2B1 mannosidase, alpha, class 2B, member 1 -2.0732
FOXN1 forkhead box N1 -2.0573
KPLCE KPRP N-terminal and LCE C-terminal like protein -2.057
LAPTM4B lysosomal protein transmembrane 4 beta -2.05595
BTNL2 butyrophilin-like 2 -2.0535
PCDHGA1 protocadherin gamma subfamily A, 1 -2.0534
XPO6 exportin 6 -2.05332
ZNF500 zinc finger protein 500 -2.05318
THRB thyroid hormone receptor, beta -2.0527
NR5A1 nuclear receptor subfamily 5, group A, member 1 -2.0516
EVX1 even-skipped homeobox 1 -2.04635
TBC1D10C TBC1 domain family, member 10C -2.04585
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 -2.04025
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.0348
C2CD3 C2 calcium-dependent domain containing 3 -2.03262
LTB4R leukotriene B4 receptor -2.03127
KRT33A keratin 33A, type I -2.03035
KIF14 kinesin family member 14 -2.0293
ZNF133 zinc finger protein 133 -2.0279
SCAF4 SR-related CTD-associated factor 4 -2.01872
MKNK1 MAP kinase interacting serine/threonine kinase 1 -2.015
FDX1 ferredoxin 1 -2.00812
FHOD1 formin homology 2 domain containing 1 -2.00765
KCNK7 potassium channel, two pore domain subfamily K, member 7 -2.00475
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.0037