CRCGN008_HEPG2_24H:I15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-benzyl 2-butyl phthalate 5.28 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN008_HEPG2_24H:I15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SQOR sulfide quinone oxidoreductase 5.6437
RPP38 ribonuclease P/MRP 38kDa subunit 5.179
UBQLN2 ubiquilin 2 5.09935
LCN2 lipocalin 2 4.8264
CRTAP cartilage associated protein 4.5947
ARL4C ADP-ribosylation factor-like 4C 4.51535
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.5148
ANO10 anoctamin 10 4.41165
RRAGA Ras-related GTP binding A 4.28725
PRR15L proline rich 15-like 4.27365
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.2498
EPHA3 EPH receptor A3 4.13668
NMU neuromedin U 3.88085
SSBP2 single-stranded DNA binding protein 2 3.8807
EGF epidermal growth factor 3.77845
BTK Bruton agammaglobulinemia tyrosine kinase 3.70175
PRKCH protein kinase C, eta 3.43583
TRAM2 translocation associated membrane protein 2 3.32087
STXBP2 syntaxin binding protein 2 3.28275
TBP TATA box binding protein 3.09445
CHN1 chimerin 1 3.0745
SLC75A1 solute carrier family 75 member 1 3.02305
CDPF1 cysteine-rich, DPF motif domain containing 1 2.9736
KLHL9 kelch-like family member 9 2.96077
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.94877
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.9397
USP6NL USP6 N-terminal like 2.70165
BPHL biphenyl hydrolase-like (serine hydrolase) 2.69865
GPATCH8 G patch domain containing 8 2.63477
TAC4 tachykinin 4 (hemokinin) 2.61095
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.5482
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.53005
SF3B4 splicing factor 3b, subunit 4, 49kDa 2.44165
CD2AP CD2-associated protein 2.4168
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.33135
ZNF318 zinc finger protein 318 2.25152
MCM3 minichromosome maintenance complex component 3 2.248
ARHGAP9 Rho GTPase activating protein 9 2.24145
GLI2 GLI family zinc finger 2 2.21765
FLRT2 fibronectin leucine rich transmembrane protein 2 2.17943
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.13905
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.09555
ADAT1 adenosine deaminase, tRNA-specific 1 2.08265
CREG1 cellular repressor of E1A-stimulated genes 1 2.08175
SUCO SUN domain containing ossification factor 2.07975
PDCD6IP programmed cell death 6 interacting protein 2.0758
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 2.00885

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -5.33865
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.25325
PCNA proliferating cell nuclear antigen -4.81965
CAB39 calcium binding protein 39 -4.77645
ARID5B AT rich interactive domain 5B (MRF1-like) -4.7065
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.5829
ZNF586 zinc finger protein 586 -4.4959
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.4542
CCNB1 cyclin B1 -4.27515
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.21502
ITGB1BP1 integrin beta 1 binding protein 1 -4.21475
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.63505
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.48345
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.38415
GNAS GNAS complex locus -3.32404
MRPS7 mitochondrial ribosomal protein S7 -3.3025
TMEM94 transmembrane protein 94 -2.8324
CD58 CD58 molecule -2.75092
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.6792
MRPL58 mitochondrial ribosomal protein L58 -2.67075
TLR4 toll-like receptor 4 -2.64985
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.64185
BLCAP bladder cancer associated protein -2.58845
CSDC2 cold shock domain containing C2, RNA binding -2.49375
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.4819
NLRP4 NLR family, pyrin domain containing 4 -2.4615
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.44315
SAP30BP SAP30 binding protein -2.39895
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.35678
SUMO4 small ubiquitin-like modifier 4 -2.35085
PDIA5 protein disulfide isomerase family A, member 5 -2.35
ACSM5 acyl-CoA synthetase medium-chain family member 5 -2.30658
ATF5 activating transcription factor 5 -2.29682
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.2957
KCTD2 potassium channel tetramerization domain containing 2 -2.27238
SMC6 structural maintenance of chromosomes 6 -2.24635
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.23682
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.22255
ZW10 zw10 kinetochore protein -2.22155
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -2.2132
RBM15 RNA binding motif protein 15 -2.21167
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.18775
H3-3B H3.3 histone B -2.17489
TMEM248 transmembrane protein 248 -2.14145
CDR2L cerebellar degeneration-related protein 2-like -2.1278
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.12355
BLMH bleomycin hydrolase -2.12065
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -2.0175
ZDHHC6 zinc finger, DHHC-type containing 6 -2.01685
HELZ helicase with zinc finger -2.0084
CES3 carboxylesterase 3 -2.00035