CRCGN008_HEPG2_24H:I17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-benzyl 2-butyl phthalate 1.32 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN008_HEPG2_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO1 anoctamin 1, calcium activated chloride channel 6.2434
PNKP polynucleotide kinase 3'-phosphatase 5.79
E2F2 E2F transcription factor 2 5.16375
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.14425
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.13775
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.10865
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 5.0
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.5497
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.01355
SSBP2 single-stranded DNA binding protein 2 3.91753
GPER1 G protein-coupled estrogen receptor 1 3.4884
CHEK2 checkpoint kinase 2 3.4214
FPGS folylpolyglutamate synthase 3.3382
PRR15L proline rich 15-like 3.29335
CYCS cytochrome c, somatic 3.2352
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.1804
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.05452
CCL2 chemokine (C-C motif) ligand 2 3.0263
WASF3 WAS protein family, member 3 2.718
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.7113
LSR lipolysis stimulated lipoprotein receptor 2.7048
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.6594
HLA-DRA major histocompatibility complex, class II, DR alpha 2.62248
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.53895
CD163L1 CD163 molecule-like 1 2.4651
SELENOW selenoprotein W 2.45525
AK4 adenylate kinase 4 2.4367
GMEB1 glucocorticoid modulatory element binding protein 1 2.43585
TRAPPC13 trafficking protein particle complex 13 2.42135
CEMIP2 cell migration inducing hyaluronidase 2 2.3792
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.3249
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.26215
INHA inhibin, alpha 2.2253
BAG3 BCL2-associated athanogene 3 2.2056
LOC122526780 uncharacterized LOC122526780 2.1612
NUP93 nucleoporin 93kDa 2.1598
TFCP2L1 transcription factor CP2-like 1 2.149
KLHDC8A kelch domain containing 8A 2.1404
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.13375
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.10885
CGRRF1 cell growth regulator with ring finger domain 1 2.10015
RGN regucalcin 2.0916
FICD FIC domain containing 2.06635
ZCCHC10 zinc finger, CCHC domain containing 10 2.05475
MAGT1 magnesium transporter 1 2.03535
NLGN4X neuroligin 4, X-linked 2.0252
HOMER1 homer scaffolding protein 1 2.02145

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -10.0
DNM1L dynamin 1-like -5.22515
LDHD lactate dehydrogenase D -5.08075
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.9478
CCDC86 coiled-coil domain containing 86 -4.78445
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.71465
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.70845
TSPAN4 tetraspanin 4 -4.64372
ADI1 acireductone dioxygenase 1 -4.5923
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -4.31035
GNAS GNAS complex locus -3.81759
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.80015
HLA-DMA major histocompatibility complex, class II, DM alpha -3.79315
YME1L1 YME1-like 1 ATPase -3.78312
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.5087
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.405
OXA1L oxidase (cytochrome c) assembly 1-like -3.2226
SCAND1 SCAN domain containing 1 -3.04515
CCNB2 cyclin B2 -2.88545
AURKB aurora kinase B -2.80045
STAT1 signal transducer and activator of transcription 1, 91kDa -2.59314
CTAG2 cancer/testis antigen 2 -2.31738
MEN1 multiple endocrine neoplasia I -2.3066
EGFL6 EGF-like-domain, multiple 6 -2.21865
MAGEA9B melanoma antigen family A9B -2.18855
GPR19 G protein-coupled receptor 19 -2.16535
DAPL1 death associated protein-like 1 -2.1357
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -2.1192
LOC100533997 MAGEA10-MAGEA5 readthrough -2.08535
ZNF423 zinc finger protein 423 -2.0468
MCTP2 multiple C2 domains, transmembrane 2 -2.0361
MAGEA12 melanoma antigen family A12 -2.01285