CRCGN008_HEPG2_24H:I20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description felbamate 10.07 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN008_HEPG2_24H:I20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
CYCS cytochrome c, somatic 6.1699
HLA-DMA major histocompatibility complex, class II, DM alpha 5.29355
RPL39L ribosomal protein L39-like 5.0887
LAGE3 L antigen family, member 3 4.9832
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.91505
ALDOC aldolase C, fructose-bisphosphate 4.8781
ADRB2 adrenoceptor beta 2, surface 4.7935
E2F2 E2F transcription factor 2 4.681
MAMLD1 mastermind-like domain containing 1 4.53865
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.457
HOXA10 homeobox A10 4.42005
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.3309
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.28115
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.93898
CDCA4 cell division cycle associated 4 3.7157
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.6586
PMM2 phosphomannomutase 2 3.34855
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 3.26102
EVL Enah/Vasp-like 3.2111
HEBP1 heme binding protein 1 3.0695
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.92178
TIAM1 T-cell lymphoma invasion and metastasis 1 2.8466
BTK Bruton agammaglobulinemia tyrosine kinase 2.82005
STXBP2 syntaxin binding protein 2 2.71315
WDTC1 WD and tetratricopeptide repeats 1 2.63437
PTK2 protein tyrosine kinase 2 2.6343
GPATCH8 G patch domain containing 8 2.51433
KIF20A kinesin family member 20A 2.4568
ZNF589 zinc finger protein 589 2.37327
EPHA3 EPH receptor A3 2.36708
SFTPB surfactant protein B 2.34248
ALOX12 arachidonate 12-lipoxygenase 2.3091
HOXA11 homeobox A11 2.30268
TXNL4B thioredoxin-like 4B 2.2825
CORO1A coronin, actin binding protein, 1A 2.2739
GLO1 glyoxalase I 2.27385
NPDC1 neural proliferation, differentiation and control, 1 2.27045
AHR aryl hydrocarbon receptor 2.1997
MRPS10 mitochondrial ribosomal protein S10 2.1988
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.198
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.1931
FBXO34 F-box protein 34 2.1539
ZBTB5 zinc finger and BTB domain containing 5 2.1352
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.11655
COL11A2 collagen, type XI, alpha 2 2.11077
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 2.09575
SINHCAF SIN3-HDAC complex associated factor 2.09405
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.07805
ZNF492 zinc finger protein 492 2.0753
ZC3H3 zinc finger CCCH-type containing 3 2.0679
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.05615
DLK2 delta-like 2 homolog (Drosophila) 2.04975
GMPPA GDP-mannose pyrophosphorylase A 2.0481
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.02945
VAMP7 vesicle-associated membrane protein 7 2.0187
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.016
BCAS3 breast carcinoma amplified sequence 3 2.0083
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.00375

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.25245
DSG2 desmoglein 2 -5.56835
INPP1 inositol polyphosphate-1-phosphatase -5.4132
SLC35F2 solute carrier family 35, member F2 -5.3845
TSPAN4 tetraspanin 4 -5.03923
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.86795
LDHD lactate dehydrogenase D -4.8129
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.4768
CCNB2 cyclin B2 -4.41865
RPS5 ribosomal protein S5 -4.37015
NRIP1 nuclear receptor interacting protein 1 -4.1288
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.6837
MAPK13 mitogen-activated protein kinase 13 -3.6557
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.5627
REEP5 receptor accessory protein 5 -3.34538
MTA1 metastasis associated 1 -3.19235
TXNRD1 thioredoxin reductase 1 -3.1417
GLOD4 glyoxalase domain containing 4 -2.91215
TOR1A torsin family 1, member A (torsin A) -2.88558
NVL nuclear VCP-like -2.78615
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.72893
CD58 CD58 molecule -2.64657
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.53115
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.38893
ZNF586 zinc finger protein 586 -2.3823
BAZ1A bromodomain adjacent to zinc finger domain, 1A -2.36373
FBXO3 F-box protein 3 -2.29395
CLNS1A chloride channel, nucleotide-sensitive, 1A -2.23855
FOS FBJ murine osteosarcoma viral oncogene homolog -2.2348
ETHE1 ethylmalonic encephalopathy 1 -2.2099
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -2.19805
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.19185
RWDD1 RWD domain containing 1 -2.17525
EVA1B eva-1 homolog B (C. elegans) -2.15297
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.12195
TMEM87A transmembrane protein 87A -2.0806
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa -2.0786
CSNK1G3 casein kinase 1, gamma 3 -2.04045
RAB26 RAB26, member RAS oncogene family -2.0267
PEX13 peroxisomal biogenesis factor 13 -2.022