CRCGN008_HEPG2_24H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description felbamate 5.04 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

184 genes differentially expressed following the CRCGN008_HEPG2_24H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 7.817
CYCS cytochrome c, somatic 6.5948
CBR3 carbonyl reductase 3 5.5315
TIMP2 TIMP metallopeptidase inhibitor 2 5.33725
CARMIL1 capping protein regulator and myosin 1 linker 1 5.2505
ADGRE5 adhesion G protein-coupled receptor E5 5.1899
ATP11B ATPase, class VI, type 11B 5.0262
STAP2 signal transducing adaptor family member 2 4.87715
IGFBP3 insulin-like growth factor binding protein 3 4.8568
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.6777
E2F2 E2F transcription factor 2 4.66275
PPARG peroxisome proliferator-activated receptor gamma 4.60805
EPHB2 EPH receptor B2 4.46065
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.29255
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.21755
EVL Enah/Vasp-like 3.69065
CD40 CD40 molecule, TNF receptor superfamily member 5 3.59154
PRR15L proline rich 15-like 3.5207
SLC75A1 solute carrier family 75 member 1 3.38885
DMTF1 cyclin D binding myb-like transcription factor 1 3.26938
CDC45 cell division cycle 45 3.2686
LPA lipoprotein, Lp(a) 3.0545
TIAM1 T-cell lymphoma invasion and metastasis 1 3.04875
AURKB aurora kinase B 3.02355
NOSIP nitric oxide synthase interacting protein 3.02105
CDK19 cyclin-dependent kinase 19 2.95453
LIN7B lin-7 homolog B (C. elegans) 2.925
NMU neuromedin U 2.87545
LPAR2 lysophosphatidic acid receptor 2 2.77728
LSR lipolysis stimulated lipoprotein receptor 2.6524
APOF apolipoprotein F 2.6443
AKR1D1 aldo-keto reductase family 1, member D1 2.6181
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 2.59235
SATB2 SATB homeobox 2 2.59018
GRM2 glutamate receptor, metabotropic 2 2.5799
CEMIP2 cell migration inducing hyaluronidase 2 2.55945
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 2.5562
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.551
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.54712
GARRE1 granule associated Rac and RHOG effector 1 2.53385
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.52515
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.4979
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.4738
DUSP21 dual specificity phosphatase 21 2.4684
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.4543
FOXB1 forkhead box B1 2.43895
GALK1 galactokinase 1 2.4252
FEZF2 FEZ family zinc finger 2 2.4191
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.4181
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.40135
TEF thyrotrophic embryonic factor 2.39585
CRYGA crystallin, gamma A 2.39295
NOX1 NADPH oxidase 1 2.37478
FZD8 frizzled class receptor 8 2.37305
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.36755
RDH16 retinol dehydrogenase 16 (all-trans) 2.362
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.35005
HGFAC HGF activator 2.3343
LRRC3 leucine rich repeat containing 3 2.33
CDHR1 cadherin-related family member 1 2.3234
FETUB fetuin B 2.3123
CDH8 cadherin 8, type 2 2.31095
PSPN persephin 2.30785
GYS2 glycogen synthase 2 (liver) 2.30505
OPN1MW3 opsin 1, medium wave sensitive 3 2.30375
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.29475
TULP1 tubby like protein 1 2.2937
CLDN14 claudin 14 2.27725
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.27705
THAP7 THAP domain containing 7 2.27365
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.26555
WNT2B wingless-type MMTV integration site family, member 2B 2.25507
FRYL FRY-like 2.2386
ADAP2 ArfGAP with dual PH domains 2 2.23385
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 2.21855
STMN3 stathmin-like 3 2.21815
MYH13 myosin, heavy chain 13, skeletal muscle 2.2163
CMA1 chymase 1, mast cell 2.2089
NRL neural retina leucine zipper 2.20568
CNMD chondromodulin 2.2056
GPR68 G protein-coupled receptor 68 2.20535
CDX4 caudal type homeobox 4 2.20015
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.18675
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.1853
RGS9BP regulator of G protein signaling 9 binding protein 2.17845
ZGPAT zinc finger, CCCH-type with G patch domain 2.1774
PPP1R37 protein phosphatase 1, regulatory subunit 37 2.17502
GRIK1 glutamate receptor, ionotropic, kainate 1 2.17295
GRM4 glutamate receptor, metabotropic 4 2.168
GSPT2 G1 to S phase transition 2 2.15445
MATN4 matrilin 4 2.1519
GRTP1 growth hormone regulated TBC protein 1 2.14765
TPMT thiopurine S-methyltransferase 2.14447
BRSK2 BR serine/threonine kinase 2 2.1378
GSTZ1 glutathione S-transferase zeta 1 2.13515
AKAP5 A kinase (PRKA) anchor protein 5 2.1273
NPC1L1 NPC1-like 1 2.1236
HMHB1 histocompatibility (minor) HB-1 2.1226
JCAD junctional cadherin 5 associated 2.1197
ADAT1 adenosine deaminase, tRNA-specific 1 2.1147
MMP23B matrix metallopeptidase 23B 2.1103
FABP1 fatty acid binding protein 1, liver 2.10825
GRIK4 glutamate receptor, ionotropic, kainate 4 2.10665
OSBPL7 oxysterol binding protein-like 7 2.10192
LMTK2 lemur tyrosine kinase 2 2.0995
AKT2 v-akt murine thymoma viral oncogene homolog 2 2.0988
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.09875
AANAT aralkylamine N-acetyltransferase 2.0979
CCL24 chemokine (C-C motif) ligand 24 2.0952
CD160 CD160 molecule 2.0914
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.08565
DGKB diacylglycerol kinase, beta 90kDa 2.07715
NEUROG1 neurogenin 1 2.0764
WNT3 wingless-type MMTV integration site family, member 3 2.07325
NR1I2 nuclear receptor subfamily 1, group I, member 2 2.07323
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 2.06935
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.06735
FGF8 fibroblast growth factor 8 (androgen-induced) 2.05785
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.0553
NANOS2 nanos homolog 2 (Drosophila) 2.05055
RXFP3 relaxin/insulin-like family peptide receptor 3 2.05015
RPE65 retinal pigment epithelium-specific protein 65kDa 2.04905
WNT1 wingless-type MMTV integration site family, member 1 2.04805
PCDH11X protocadherin 11 X-linked 2.04759
SSTR1 somatostatin receptor 1 2.0417
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.03548
DBF4B DBF4 zinc finger B 2.03505
EPN3 epsin 3 2.02745
NMUR1 neuromedin U receptor 1 2.02575
INSL5 insulin-like 5 2.02125
FOXD3 forkhead box D3 2.0112
BTBD8 BTB (POZ) domain containing 8 2.01055
FSCN2 fascin actin-bundling protein 2, retinal 2.0058
GSTT1 glutathione S-transferase theta 1 2.00095
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 2.0009
OCLN occludin 2.0002

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.9757
OXA1L oxidase (cytochrome c) assembly 1-like -6.07925
TLCD3A TLC domain containing 3A -5.4796
ISOC1 isochorismatase domain containing 1 -5.30285
NT5DC2 5'-nucleotidase domain containing 2 -5.28385
TUBB6 tubulin, beta 6 class V -5.12595
CD320 CD320 molecule -5.01685
DNM1L dynamin 1-like -4.96225
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.83225
PCNA proliferating cell nuclear antigen -4.77245
CDC20 cell division cycle 20 -4.6933
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -4.6161
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.49585
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -4.24807
HLA-DMA major histocompatibility complex, class II, DM alpha -4.17005
TRAPPC3 trafficking protein particle complex 3 -4.0059
CCNB2 cyclin B2 -3.9547
FASTKD5 FAST kinase domains 5 -3.81375
FHL2 four and a half LIM domains 2 -3.7255
ASCC3 activating signal cointegrator 1 complex subunit 3 -3.43215
RHEB Ras homolog enriched in brain -3.29357
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.90275
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.8985
CPNE3 copine III -2.89175
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.77085
FBXL12 F-box and leucine-rich repeat protein 12 -2.7384
UIMC1 ubiquitin interaction motif containing 1 -2.4919
MRPS15 mitochondrial ribosomal protein S15 -2.4321
WASHC4 WASH complex subunit 4 -2.39247
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.31945
NRDC nardilysin convertase -2.26095
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.2608
ZNF384 zinc finger protein 384 -2.2029
PTPRG protein tyrosine phosphatase, receptor type, G -2.1951
NOP2 NOP2 nucleolar protein -2.1438
TFG TRK-fused gene -2.1384
KDM3B lysine (K)-specific demethylase 3B -2.13093
LIMS1 LIM and senescent cell antigen-like domains 1 -2.1282
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1105
BMP4 bone morphogenetic protein 4 -2.0763
LMBR1L limb development membrane protein 1-like -2.07145
IFT81 intraflagellar transport 81 -2.06015
DRAM1 DNA-damage regulated autophagy modulator 1 -2.05295
ARHGAP17 Rho GTPase activating protein 17 -2.03785
APH1B APH1B gamma secretase subunit -2.031
TRIT1 tRNA isopentenyltransferase 1 -2.02705
TRIM22 tripartite motif containing 22 -2.01765
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.0061