CRCGN008_HEPG2_24H:I24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description felbamate 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN008_HEPG2_24H:I24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.1417
GPER1 G protein-coupled estrogen receptor 1 3.62318
LSR lipolysis stimulated lipoprotein receptor 3.31705
GPATCH8 G patch domain containing 8 2.65555
CCNF cyclin F 2.64298
CKM creatine kinase, muscle 2.45275
PLSCR3 phospholipid scramblase 3 2.4265
ACTA1 actin, alpha 1, skeletal muscle 2.39495
TAC4 tachykinin 4 (hemokinin) 2.3445
TMEM39B transmembrane protein 39B 2.31925
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.28338
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.19365
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.1667
MYL11 myosin light chain 11 2.16605
TRIM13 tripartite motif containing 13 2.1183
WDTC1 WD and tetratricopeptide repeats 1 2.11143
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.0659
CENPM centromere protein M 2.0587
SLAMF7 SLAM family member 7 2.03435
VRK2 vaccinia related kinase 2 2.03245
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.0247
FOXJ2 forkhead box J2 2.01855
NUP133 nucleoporin 133kDa 2.00835
CHD1L chromodomain helicase DNA binding protein 1-like 2.00735
ECD ecdysoneless homolog (Drosophila) 2.0071

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
DSG2 desmoglein 2 -5.38095
LDHD lactate dehydrogenase D -4.94305
DERA deoxyribose-phosphate aldolase (putative) -4.9237
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -4.90147
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.8821
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.7015
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.48012
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.384
ARID5B AT rich interactive domain 5B (MRF1-like) -4.25015
RHEB Ras homolog enriched in brain -4.0554
GNAS GNAS complex locus -3.70569
HLA-DMA major histocompatibility complex, class II, DM alpha -3.6978
MAPK13 mitogen-activated protein kinase 13 -3.68977
FASTKD5 FAST kinase domains 5 -3.5657
FGFR4 fibroblast growth factor receptor 4 -3.53282
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.5282
CCNB2 cyclin B2 -3.19755
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.07395
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.01938
OXA1L oxidase (cytochrome c) assembly 1-like -2.90515
TMEM230 transmembrane protein 230 -2.85055
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.83715
MAVS mitochondrial antiviral signaling protein -2.83625
ZMIZ1 zinc finger, MIZ-type containing 1 -2.80935
SNX11 sorting nexin 11 -2.71745
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.69503
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.61417
RNF167 ring finger protein 167 -2.5836
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.48125
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.4662
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.43275
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.4081
RAB5IF RAB5 interacting factor -2.4036
DDIT4 DNA-damage-inducible transcript 4 -2.3578
PLCB4 phospholipase C, beta 4 -2.33422
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.31
HSPA1B heat shock 70kDa protein 1B -2.26965
RIN2 Ras and Rab interactor 2 -2.26515
PHOX2B paired-like homeobox 2b -2.2293
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.2292
WASHC4 WASH complex subunit 4 -2.22703
ATF5 activating transcription factor 5 -2.20812
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.20675
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.20255
MTX2 metaxin 2 -2.2012
ZNF133 zinc finger protein 133 -2.1862
FKBP1C FK506 binding protein 1C -2.14572
PANK2 pantothenate kinase 2 -2.1357
OCEL1 occludin/ELL domain containing 1 -2.12765
CTNNA2 catenin (cadherin-associated protein), alpha 2 -2.12535
EIF4A3 eukaryotic translation initiation factor 4A3 -2.11485
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.10155
SNCAIP synuclein, alpha interacting protein -2.0915
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.0339
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -2.0337
PARP12 poly (ADP-ribose) polymerase family, member 12 -2.02435
DDRGK1 DDRGK domain containing 1 -2.0215
NSFL1C NSFL1 (p97) cofactor (p47) -2.01835