CRCGN008_HEPG2_24H:J01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4'-amino[1,1'-biphenyl]-4-ylamine 19.54 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN008_HEPG2_24H:J01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 6.7321
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.45715
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.2021
MMP2 matrix metallopeptidase 2 4.87795
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.81815
PPARG peroxisome proliferator-activated receptor gamma 4.29535
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.2573
ADGRE5 adhesion G protein-coupled receptor E5 4.1387
SSBP2 single-stranded DNA binding protein 2 4.04868
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.03682
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.65892
LPAR2 lysophosphatidic acid receptor 2 3.62902
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.51512
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.46222
SNAP25 synaptosomal-associated protein, 25kDa 3.20907
VGLL4 vestigial-like family member 4 3.18105
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.1119
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.78845
PPA2 pyrophosphatase (inorganic) 2 2.77805
CHN1 chimerin 1 2.7663
CCNF cyclin F 2.742
MTA2 metastasis associated 1 family, member 2 2.6111
ADAM10 ADAM metallopeptidase domain 10 2.49887
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.4964
CREG1 cellular repressor of E1A-stimulated genes 1 2.41085
BPHL biphenyl hydrolase-like (serine hydrolase) 2.3919
EML3 echinoderm microtubule associated protein like 3 2.36933
JADE2 jade family PHD finger 2 2.35512
PEX11B peroxisomal biogenesis factor 11 beta 2.29285
KLHL9 kelch-like family member 9 2.21848
TLR4 toll-like receptor 4 2.0727
MRPL12 mitochondrial ribosomal protein L12 2.0715
BSG basigin (Ok blood group) 2.06715
NUP133 nucleoporin 133kDa 2.06395

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -5.318
SLC35F2 solute carrier family 35, member F2 -4.64755
FGFR4 fibroblast growth factor receptor 4 -3.9598
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.7644
FASTKD5 FAST kinase domains 5 -3.3533
DERA deoxyribose-phosphate aldolase (putative) -3.27355
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.10855
ICAM3 intercellular adhesion molecule 3 -2.8948
OXA1L oxidase (cytochrome c) assembly 1-like -2.69965
DPH2 DPH2 homolog (S. cerevisiae) -2.49765
FHL2 four and a half LIM domains 2 -2.3737
FBXL12 F-box and leucine-rich repeat protein 12 -2.36305
EXT1 exostosin glycosyltransferase 1 -2.28557
RGS2 regulator of G-protein signaling 2 -2.24795
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.1883
FAM169A family with sequence similarity 169, member A -2.0823
FLNB filamin B, beta -2.06358
PALM2AKAP2 PALM2 and AKAP2 fusion -2.01723