CRCGN008_HEPG2_24H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4'-amino[1,1'-biphenyl]-4-ylamine 9.77 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN008_HEPG2_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.81685
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.59835
NOTCH1 notch 1 5.0925
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.0195
ATP11B ATPase, class VI, type 11B 4.92515
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.882
STK10 serine/threonine kinase 10 4.84333
WDTC1 WD and tetratricopeptide repeats 1 4.11947
CHN1 chimerin 1 3.95175
EGF epidermal growth factor 3.85955
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.23955
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.13615
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.06617
CDK19 cyclin-dependent kinase 19 2.82302
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.68175
EPHA3 EPH receptor A3 2.65658
GPATCH8 G patch domain containing 8 2.57505
SCRN1 secernin 1 2.32655
CNPY3 canopy FGF signaling regulator 3 2.2501
ZNF750 zinc finger protein 750 2.10965
CD40 CD40 molecule, TNF receptor superfamily member 5 2.08911
CGRRF1 cell growth regulator with ring finger domain 1 2.08105
PPP6R1 protein phosphatase 6, regulatory subunit 1 2.07595
RAB5B RAB5B, member RAS oncogene family 2.07215

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.32045
ACOT9 acyl-CoA thioesterase 9 -5.1652
UGDH UDP-glucose 6-dehydrogenase -5.0
LDHD lactate dehydrogenase D -4.861
TRIB3 tribbles pseudokinase 3 -4.8087
ZMIZ1 zinc finger, MIZ-type containing 1 -4.6698
FASTKD5 FAST kinase domains 5 -4.432
HMG20B high mobility group 20B -3.6317
RPS5 ribosomal protein S5 -3.59985
ACAA1 acetyl-CoA acyltransferase 1 -2.777
TES testin LIM domain protein -2.55012
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.50853
CCP110 centriolar coiled coil protein 110kDa -2.44285
FBXL12 F-box and leucine-rich repeat protein 12 -2.3786
ITGB1BP1 integrin beta 1 binding protein 1 -2.27743
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.2349
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1174
PWP2 PWP2 periodic tryptophan protein homolog (yeast) -2.09215
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.04335