| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4'-amino[1,1'-biphenyl]-4-ylamine 2.44 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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57 genes differentially expressed following the CRCGN008_HEPG2_24H:J04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPARG | peroxisome proliferator-activated receptor gamma | 4.94425 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.9073 |
| ATP11B | ATPase, class VI, type 11B | 4.6886 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.6482 |
| ADRB2 | adrenoceptor beta 2, surface | 4.5861 |
| NMU | neuromedin U | 4.4244 |
| NOTCH1 | notch 1 | 4.2171 |
| RRAGA | Ras-related GTP binding A | 3.8698 |
| PLSCR3 | phospholipid scramblase 3 | 3.31792 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.25752 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.233 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 3.1293 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 3.10385 |
| CDCA4 | cell division cycle associated 4 | 2.77915 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.65015 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.59532 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.53985 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.5262 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.46155 |
| USP6NL | USP6 N-terminal like | 2.37845 |
| CHEK2 | checkpoint kinase 2 | 2.31765 |
| CYCS | cytochrome c, somatic | 2.28515 |
| RBM34 | RNA binding motif protein 34 | 2.25183 |
| CRTAP | cartilage associated protein | 2.1655 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.1155 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.1146 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.1047 |
| FAIM | Fas apoptotic inhibitory molecule | 2.06795 |
| SORBS3 | sorbin and SH3 domain containing 3 | 2.02432 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC20 | cell division cycle 20 | -5.318 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -5.027 |
| TRIB3 | tribbles pseudokinase 3 | -4.92065 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.5491 |
| FASTKD5 | FAST kinase domains 5 | -4.19605 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.11617 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -4.0584 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.57885 |
| GNAS | GNAS complex locus | -3.51533 |
| CCNB2 | cyclin B2 | -3.4467 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -3.31163 |
| FHL2 | four and a half LIM domains 2 | -3.2372 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.17088 |
| MAP7 | microtubule-associated protein 7 | -2.80445 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.72865 |
| CD63 | CD63 molecule | -2.6935 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.5519 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.51645 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -2.50435 |
| TOMM70 | translocase of outer mitochondrial membrane 70 | -2.47465 |
| RGS2 | regulator of G-protein signaling 2 | -2.43325 |
| RNF167 | ring finger protein 167 | -2.17385 |
| CSRNP3 | cysteine-serine-rich nuclear protein 3 | -2.1431 |
| YBX2 | Y box binding protein 2 | -2.1371 |
| HDAC11 | histone deacetylase 11 | -2.0751 |
| ZC2HC1C | zinc finger, C2HC-type containing 1C | -2.02385 |
| CDHR2 | cadherin-related family member 2 | -2.0149 |
| PPM1E | protein phosphatase, Mg2+/Mn2+ dependent, 1E | -2.00765 |
