CRCGN008_HEPG2_24H:J05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4'-amino[1,1'-biphenyl]-4-ylamine 1.22 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN008_HEPG2_24H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
JADE2 jade family PHD finger 2 5.80925
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.038
STIMATE STIM activating enhancer 4.7639
SNAP25 synaptosomal-associated protein, 25kDa 4.67103
STK10 serine/threonine kinase 10 4.17153
SSBP2 single-stranded DNA binding protein 2 4.06865
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.00585
EGF epidermal growth factor 3.81635
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 3.7427
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.09525
CHN1 chimerin 1 2.98625
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.767
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.68525
ADAT1 adenosine deaminase, tRNA-specific 1 2.6433
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.6368
TIAM1 T-cell lymphoma invasion and metastasis 1 2.5857
ZNF589 zinc finger protein 589 2.40493
UXS1 UDP-glucuronate decarboxylase 1 2.37625
STXBP2 syntaxin binding protein 2 2.36395
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.35663
NFIL3 nuclear factor, interleukin 3 regulated 2.26275
CEP57 centrosomal protein 57kDa 2.25567
VANGL1 VANGL planar cell polarity protein 1 2.0673
RBMS1 RNA binding motif, single stranded interacting protein 1 2.06194

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCDC86 coiled-coil domain containing 86 -5.26925
ZNF586 zinc finger protein 586 -5.05665
CHMP4B charged multivesicular body protein 4B -4.61945
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.4664
RFC2 replication factor C (activator 1) 2, 40kDa -3.96525
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.17455
OXA1L oxidase (cytochrome c) assembly 1-like -3.0397
MAPK13 mitogen-activated protein kinase 13 -3.03877
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.7641
MAGEL2 melanoma antigen family L2 -2.6986
RBM34 RNA binding motif protein 34 -2.56223
ZNF215 zinc finger protein 215 -2.5086
DAPK2 death-associated protein kinase 2 -2.45605
NRIP1 nuclear receptor interacting protein 1 -2.3225
CDC25B cell division cycle 25B -2.31845
CCKAR cholecystokinin A receptor -2.2253
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) -2.21703
HROB homologous recombination factor with OB-fold -2.1839
ZNF528 zinc finger protein 528 -2.15375
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.13345
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.1323
TMEM143 transmembrane protein 143 -2.11345
TEX13B testis expressed 13B -2.07855
PFKM phosphofructokinase, muscle -2.063
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 -2.0265
CD300C CD300c molecule -2.0249
IL18R1 interleukin 18 receptor 1 -2.02345
HCCS holocytochrome c synthase -2.0103