CRCGN008_HEPG2_24H:J06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4'-amino[1,1'-biphenyl]-4-ylamine 0.61 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

147 genes differentially expressed following the CRCGN008_HEPG2_24H:J06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SQOR sulfide quinone oxidoreductase 5.1753
BACE2 beta-site APP-cleaving enzyme 2 5.10785
UBQLN2 ubiquilin 2 5.012
CBR3 carbonyl reductase 3 5.0
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.8063
STK10 serine/threonine kinase 10 4.7594
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.6965
HOXA10 homeobox A10 4.68865
PNKP polynucleotide kinase 3'-phosphatase 4.407
EGF epidermal growth factor 4.3287
ARL4C ADP-ribosylation factor-like 4C 4.24995
SSBP2 single-stranded DNA binding protein 2 4.05577
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.00305
CYCS cytochrome c, somatic 3.64575
CHN1 chimerin 1 3.28055
LCN2 lipocalin 2 3.00085
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.87555
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.78645
TDG thymine-DNA glycosylase 2.75085
NPDC1 neural proliferation, differentiation and control, 1 2.72935
RAB21 RAB21, member RAS oncogene family 2.6927
MLF1 myeloid leukemia factor 1 2.67275
HLA-DRA major histocompatibility complex, class II, DR alpha 2.5452
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 2.41765
CTPS1 CTP synthase 1 2.2679
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2.2433
BPHL biphenyl hydrolase-like (serine hydrolase) 2.13895
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.12103
EPHA3 EPH receptor A3 2.07855
WLS wntless Wnt ligand secretion mediator 2.0302
CRY1 cryptochrome circadian clock 1 2.02775
MORC3 MORC family CW-type zinc finger 3 2.0092
RALY RALY heterogeneous nuclear ribonucleoprotein 2.00585
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 2.00505

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -10.0
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -10.0
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.5963
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.49305
LDHD lactate dehydrogenase D -5.03465
ZNF586 zinc finger protein 586 -4.9132
FASTKD5 FAST kinase domains 5 -4.9118
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.62225
MRPS2 mitochondrial ribosomal protein S2 -4.5942
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.33815
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.34705
MAPK13 mitogen-activated protein kinase 13 -3.08833
PPP1R26 protein phosphatase 1, regulatory subunit 26 -3.0795
OXA1L oxidase (cytochrome c) assembly 1-like -3.0454
RNF208 ring finger protein 208 -2.9493
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.90805
GATA1 GATA binding protein 1 (globin transcription factor 1) -2.79835
NRIP1 nuclear receptor interacting protein 1 -2.77142
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 -2.6145
OBP2A odorant binding protein 2A -2.60015
COQ4 coenzyme Q4 -2.58915
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.58835
KEL Kell blood group, metallo-endopeptidase -2.5879
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.57603
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.57015
ARID4A AT rich interactive domain 4A (RBP1-like) -2.56105
CD46 CD46 molecule, complement regulatory protein -2.51127
OXT oxytocin/neurophysin I prepropeptide -2.50815
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.47175
PF4 platelet factor 4 -2.46925
CETN1 centrin, EF-hand protein, 1 -2.46755
PLA2G2E phospholipase A2, group IIE -2.43235
PAEP progestagen-associated endometrial protein -2.42365
TTLL12 tubulin tyrosine ligase-like family member 12 -2.41625
WNT11 wingless-type MMTV integration site family, member 11 -2.39905
SHPK sedoheptulokinase -2.3769
HOXC8 homeobox C8 -2.37465
CTNNA3 catenin (cadherin-associated protein), alpha 3 -2.36285
CLDN15 claudin 15 -2.339
TAC3 tachykinin 3 -2.32825
BTNL3 butyrophilin-like 3 -2.32555
RAB3D RAB3D, member RAS oncogene family -2.319
LGALS14 lectin, galactoside-binding, soluble, 14 -2.28365
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -2.2782
ZNF273 zinc finger protein 273 -2.278
RBM34 RNA binding motif protein 34 -2.26627
TET3 tet methylcytosine dioxygenase 3 -2.2643
IHH indian hedgehog -2.2578
GPR52 G protein-coupled receptor 52 -2.2506
ANAPC2 anaphase promoting complex subunit 2 -2.2466
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I -2.24355
OVGP1 oviductal glycoprotein 1, 120kDa -2.2343
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.2296
PRAMEF26 PRAME family member 26 -2.2159
ZNF282 zinc finger protein 282 -2.2097
HR hair growth associated -2.197
GFRA4 GDNF family receptor alpha 4 -2.19485
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 -2.1932
TREH trehalase (brush-border membrane glycoprotein) -2.1928
ZFAND1 zinc finger, AN1-type domain 1 -2.1605
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) -2.16025
PRDM16 PR domain containing 16 -2.15745
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.15615
LMTK2 lemur tyrosine kinase 2 -2.1473
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 -2.1472
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -2.14057
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -2.12825
PLXNB1 plexin B1 -2.1227
CD163L1 CD163 molecule-like 1 -2.1168
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.1125
ZNRF4 zinc and ring finger 4 -2.11085
CHRM4 cholinergic receptor, muscarinic 4 -2.1042
EIF3D eukaryotic translation initiation factor 3, subunit D -2.1037
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -2.10365
KLHL35 kelch-like family member 35 -2.10175
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.0968
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 -2.09535
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -2.0937
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -2.08693
H2AP H2A.P histone -2.08185
LUZP4 leucine zipper protein 4 -2.0809
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -2.08045
APOA4 apolipoprotein A-IV -2.0718
LRRC3 leucine rich repeat containing 3 -2.07065
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.06995
PES1 pescadillo ribosomal biogenesis factor 1 -2.06905
ICAM3 intercellular adhesion molecule 3 -2.06875
HLA-DOB major histocompatibility complex, class II, DO beta -2.0675
RASA4B RAS p21 protein activator 4B -2.06665
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.0603
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa -2.0567
DLEC1 deleted in lung and esophageal cancer 1 -2.0563
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I -2.0561
GLRA2 glycine receptor, alpha 2 -2.0542
PSPN persephin -2.0518
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -2.03865
OR2H1 olfactory receptor, family 2, subfamily H, member 1 -2.0351
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.032
ZNF324B zinc finger protein 324B -2.03095
ZBTB7B zinc finger and BTB domain containing 7B -2.02595
KLF15 Kruppel-like factor 15 -2.0255
DENND1C DENN/MADD domain containing 1C -2.02455
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.02445
CAB39 calcium binding protein 39 -2.0192
WDR4 WD repeat domain 4 -2.0164
DNAH2 dynein, axonemal, heavy chain 2 -2.014
RGS2 regulator of G-protein signaling 2 -2.0123
PMM1 phosphomannomutase 1 -2.0078
SIRT6 sirtuin 6 -2.00665
MELTF melanotransferrin -2.0064
HOXB1 homeobox B1 -2.00375
KCTD15 potassium channel tetramerization domain containing 15 -2.00365
HROB homologous recombination factor with OB-fold -2.00275