| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)-5-hydroxybenzenesulfonate 20.28 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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63 genes differentially expressed following the CRCGN008_HEPG2_24H:J07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYLK | myosin light chain kinase | 5.54965 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.1189 |
| ATP11B | ATPase, class VI, type 11B | 5.08265 |
| CCL2 | chemokine (C-C motif) ligand 2 | 4.5515 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.3744 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 3.9367 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.76265 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.69873 |
| ARL4C | ADP-ribosylation factor-like 4C | 3.64103 |
| KDM5A | lysine (K)-specific demethylase 5A | 3.5393 |
| EVL | Enah/Vasp-like | 3.3278 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.21345 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 3.03685 |
| CHN1 | chimerin 1 | 2.97475 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 2.94517 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.75427 |
| GPATCH8 | G patch domain containing 8 | 2.6826 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | 2.59335 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 2.4904 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 2.42995 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.37025 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.362 |
| EXOC2 | exocyst complex component 2 | 2.26645 |
| SCAMP4 | secretory carrier membrane protein 4 | 2.25025 |
| RAB31 | RAB31, member RAS oncogene family | 2.21048 |
| CELF2 | CUGBP, Elav-like family member 2 | 2.14868 |
| KCNJ14 | potassium channel, inwardly rectifying subfamily J, member 14 | 2.14595 |
| VSTM4 | V-set and transmembrane domain containing 4 | 2.1156 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.0898 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -6.376 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -5.55445 |
| LDHD | lactate dehydrogenase D | -5.2325 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -5.09765 |
| DNM1L | dynamin 1-like | -5.0091 |
| CDC20 | cell division cycle 20 | -5.0 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -4.95528 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.832 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -4.83165 |
| DUSP6 | dual specificity phosphatase 6 | -4.69617 |
| GNAS | GNAS complex locus | -4.40302 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -4.20565 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -3.99125 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.2605 |
| CCNB2 | cyclin B2 | -3.2526 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.95962 |
| ZW10 | zw10 kinetochore protein | -2.91855 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.82095 |
| RGS2 | regulator of G-protein signaling 2 | -2.8072 |
| ETNK1 | ethanolamine kinase 1 | -2.79803 |
| SNX11 | sorting nexin 11 | -2.6881 |
| GLOD4 | glyoxalase domain containing 4 | -2.601 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.56935 |
| AFF4 | AF4/FMR2 family, member 4 | -2.5403 |
| CSRP1 | cysteine and glycine-rich protein 1 | -2.46135 |
| DUSP2 | dual specificity phosphatase 2 | -2.42955 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.41905 |
| PRPF4 | pre-mRNA processing factor 4 | -2.30792 |
| DNASE2B | deoxyribonuclease II beta | -2.2678 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -2.23345 |
| TTLL7 | tubulin tyrosine ligase-like family member 7 | -2.13465 |
| EIF1B | eukaryotic translation initiation factor 1B | -2.13345 |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | -2.1211 |
| NMI | N-myc (and STAT) interactor | -2.04295 |
