| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)-5-hydroxybenzenesulfonate 10.14 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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83 genes differentially expressed following the CRCGN008_HEPG2_24H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| E2F2 | E2F transcription factor 2 | 10.0 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 5.19955 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.84805 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.7021 |
| RPL39L | ribosomal protein L39-like | 4.63915 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 4.51786 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.4723 |
| ARL4C | ADP-ribosylation factor-like 4C | 4.33777 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 4.15732 |
| SSBP2 | single-stranded DNA binding protein 2 | 4.14025 |
| ANO10 | anoctamin 10 | 3.91495 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.67725 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 3.50215 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 3.25005 |
| KDM5A | lysine (K)-specific demethylase 5A | 3.24832 |
| PRR15L | proline rich 15-like | 3.1428 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 3.07514 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.0656 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 3.05805 |
| MAP7 | microtubule-associated protein 7 | 3.0577 |
| TLR4 | toll-like receptor 4 | 3.00865 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 2.6866 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.59402 |
| ZNF589 | zinc finger protein 589 | 2.5616 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.54275 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.44025 |
| IRX5 | iroquois homeobox 5 | 2.4028 |
| CYCS | cytochrome c, somatic | 2.28875 |
| HSPA1A | heat shock 70kDa protein 1A | 2.2592 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 2.218 |
| STK17B | serine/threonine kinase 17b | 2.2066 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.19835 |
| WDR82 | WD repeat domain 82 | 2.19115 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.1866 |
| ARMC6 | armadillo repeat containing 6 | 2.17955 |
| RAB35 | RAB35, member RAS oncogene family | 2.17745 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.10855 |
| DYNC1LI1 | dynein, cytoplasmic 1, light intermediate chain 1 | 2.10005 |
| PGR | progesterone receptor | 2.0732 |
| TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | 2.0649 |
| CST3 | cystatin C | 2.0473 |
| MCTS1 | malignant T cell amplified sequence 1 | 2.04115 |
| PBK | PDZ binding kinase | 2.01505 |
| PITX2 | paired-like homeodomain 2 | 2.0014 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -9.92898 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -6.13003 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -5.5756 |
| PCNA | proliferating cell nuclear antigen | -5.33725 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.0711 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -5.0395 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -5.0 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -5.0 |
| ADI1 | acireductone dioxygenase 1 | -4.989 |
| GOLT1B | golgi transport 1B | -4.8803 |
| VAT1 | vesicle amine transport 1 | -4.8175 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -4.7997 |
| FAIM | Fas apoptotic inhibitory molecule | -4.3679 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.98472 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -3.90295 |
| GNAS | GNAS complex locus | -3.49625 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -3.23672 |
| PEG10 | paternally expressed 10 | -3.21665 |
| MTA1 | metastasis associated 1 | -2.96248 |
| LINC02762 | long intergenic non-protein coding RNA 2762 | -2.69532 |
| FHL2 | four and a half LIM domains 2 | -2.58255 |
| ATOX1 | antioxidant 1 copper chaperone | -2.4399 |
| PNPLA6 | patatin-like phospholipase domain containing 6 | -2.3978 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.379 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -2.335 |
| KIAA0930 | KIAA0930 | -2.25017 |
| GLOD4 | glyoxalase domain containing 4 | -2.2268 |
| PRODH2 | proline dehydrogenase (oxidase) 2 | -2.18365 |
| SERPINI2 | serpin peptidase inhibitor, clade I (pancpin), member 2 | -2.15835 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.1556 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -2.12902 |
| SLC23A1 | solute carrier family 23 (ascorbic acid transporter), member 1 | -2.10312 |
| CYP21A2 | cytochrome P450, family 21, subfamily A, polypeptide 2 | -2.0665 |
| TMEM184B | transmembrane protein 184B | -2.06525 |
| LY86 | lymphocyte antigen 86 | -2.055 |
| FECH | ferrochelatase | -2.05275 |
| BHMT | betaine--homocysteine S-methyltransferase | -2.0518 |
| PDS5A | PDS5 cohesin associated factor A | -2.04776 |
| TLN1 | talin 1 | -2.0322 |
