CRCGN008_HEPG2_24H:J09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)-5-hydroxybenzenesulfonate 5.07 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN008_HEPG2_24H:J09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 7.01485
E2F2 E2F transcription factor 2 5.2546
ADRB2 adrenoceptor beta 2, surface 4.9265
PLS1 plastin 1 4.85275
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.73085
NMU neuromedin U 4.67395
CDPF1 cysteine-rich, DPF motif domain containing 1 4.62965
ARL4C ADP-ribosylation factor-like 4C 4.61735
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.98117
CYCS cytochrome c, somatic 3.67955
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.65947
BIRC2 baculoviral IAP repeat containing 2 3.24045
TMEM45A transmembrane protein 45A 2.7364
METRN meteorin, glial cell differentiation regulator 2.66075
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.6049
CNPY3 canopy FGF signaling regulator 3 2.4959
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.2417
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.2324
UBE2M ubiquitin-conjugating enzyme E2M 2.22435
PRX periaxin 2.19775
ZIM3 zinc finger, imprinted 3 2.1341
CHEK2 checkpoint kinase 2 2.09432
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.05415
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.04345
CEP57 centrosomal protein 57kDa 2.02543
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.01215

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -5.21785
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.85895
FASTKD5 FAST kinase domains 5 -4.76535
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.6965
GNAS GNAS complex locus -4.22495
HLA-DMA major histocompatibility complex, class II, DM alpha -4.11735
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.364
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.0617
SLC35F2 solute carrier family 35, member F2 -3.00825
ACAA1 acetyl-CoA acyltransferase 1 -2.91368
SNX11 sorting nexin 11 -2.79705
HNMT histamine N-methyltransferase -2.72288
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.57575
NRIP1 nuclear receptor interacting protein 1 -2.51187
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -2.3841
RERGL RERG/RAS-like -2.3768
CDC25B cell division cycle 25B -2.226
SIL1 SIL1 nucleotide exchange factor -2.13
FOXN2 forkhead box N2 -2.10845
PHOX2B paired-like homeobox 2b -2.10615
PLA2G15 phospholipase A2, group XV -2.1027
SLCO5A1 solute carrier organic anion transporter family, member 5A1 -2.09595
AKR1C3 aldo-keto reductase family 1, member C3 -2.0902
TMOD2 tropomodulin 2 (neuronal) -2.07935
ATG9A autophagy related 9A -2.02275