CRCGN008_HEPG2_24H:J10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)-5-hydroxybenzenesulfonate 2.53 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN008_HEPG2_24H:J10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.14425
PRR15L proline rich 15-like 5.08905
TAC4 tachykinin 4 (hemokinin) 5.0
NMU neuromedin U 4.8037
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.6237
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.1537
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.67238
LYN LYN proto-oncogene, Src family tyrosine kinase 3.58105
SNAP25 synaptosomal-associated protein, 25kDa 3.55888
CYCS cytochrome c, somatic 3.53715
EGF epidermal growth factor 3.53635
LOC122526780 uncharacterized LOC122526780 3.4836
TBC1D31 TBC1 domain family, member 31 3.4555
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.92462
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.72638
BPHL biphenyl hydrolase-like (serine hydrolase) 2.5784
TBP TATA box binding protein 2.48685
ILK integrin-linked kinase 2.32095
LCN2 lipocalin 2 2.2528
AUH AU RNA binding protein/enoyl-CoA hydratase 2.17005
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.15305
CDK19 cyclin-dependent kinase 19 2.11823
SNX7 sorting nexin 7 2.0886
DEPTOR DEP domain containing MTOR-interacting protein 2.07205
MTCH2 mitochondrial carrier 2 2.03945
GARRE1 granule associated Rac and RHOG effector 1 2.0258
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 2.0156

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.49845
CCNB2 cyclin B2 -4.1893
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.8055
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.78155
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -3.34728
CCNB1 cyclin B1 -2.5204
WASHC4 WASH complex subunit 4 -2.49325
RBM34 RNA binding motif protein 34 -2.39002
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.24575
RBM15 RNA binding motif protein 15 -2.19808
FBXL12 F-box and leucine-rich repeat protein 12 -2.09605
NRIP1 nuclear receptor interacting protein 1 -2.0656