| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)-5-hydroxybenzenesulfonate 1.27 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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52 genes differentially expressed following the CRCGN008_HEPG2_24H:J11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CCL2 | chemokine (C-C motif) ligand 2 | 7.39355 |
| E2F2 | E2F transcription factor 2 | 5.0481 |
| UBQLN2 | ubiquilin 2 | 5.03015 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.8939 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 4.7088 |
| KLHL9 | kelch-like family member 9 | 4.43725 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.29935 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.92805 |
| GATA3 | GATA binding protein 3 | 3.88083 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.50822 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.41435 |
| EGF | epidermal growth factor | 3.39755 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 3.15355 |
| NLRP2B | NLR family pyrin domain containing 2B | 2.9847 |
| PLSCR3 | phospholipid scramblase 3 | 2.90762 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 2.8038 |
| MAP7 | microtubule-associated protein 7 | 2.68132 |
| GPATCH8 | G patch domain containing 8 | 2.67655 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.56638 |
| CCNF | cyclin F | 2.5648 |
| KIF20A | kinesin family member 20A | 2.52485 |
| HEBP1 | heme binding protein 1 | 2.47 |
| SQOR | sulfide quinone oxidoreductase | 2.44865 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 2.34235 |
| DHRS11 | dehydrogenase/reductase (SDR family) member 11 | 2.3332 |
| STXBP1 | syntaxin binding protein 1 | 2.30885 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.19365 |
| WASF3 | WAS protein family, member 3 | 2.1832 |
| LPAR6 | lysophosphatidic acid receptor 6 | 2.17245 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 2.0971 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.0919 |
| VAMP7 | vesicle-associated membrane protein 7 | 2.02185 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -6.5934 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -5.3345 |
| ADI1 | acireductone dioxygenase 1 | -4.891 |
| PCNA | proliferating cell nuclear antigen | -4.50795 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.02055 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | -2.9916 |
| ZW10 | zw10 kinetochore protein | -2.83645 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.8186 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.74185 |
| DDX23 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 | -2.28265 |
| CTDP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 | -2.25315 |
| ATF5 | activating transcription factor 5 | -2.24973 |
| PCDH17 | protocadherin 17 | -2.249 |
| NRBF2 | nuclear receptor binding factor 2 | -2.1876 |
| PCID2 | PCI domain containing 2 | -2.11915 |
| HMOX2 | heme oxygenase 2 | -2.09468 |
| GRAMD2B | GRAM domain containing 2B | -2.07755 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.04125 |
| NECTIN3 | nectin cell adhesion molecule 3 | -2.03375 |
| MYOM1 | myomesin 1 | -2.01125 |
