| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disodium 2-({4-[ethyl(3-sulfonatobenzyl)amino]phenyl}{4-[ethyl(3-sulfonatobenzyl)iminio]-2,5-cyclohexadien-1-ylidene}methyl)-5-hydroxybenzenesulfonate 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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90 genes differentially expressed following the CRCGN008_HEPG2_24H:J12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NOTCH1 | notch 1 | 5.3099 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.18445 |
| CHMP6 | charged multivesicular body protein 6 | 5.1004 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 5.06125 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.80975 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 4.7981 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.6635 |
| PNKP | polynucleotide kinase 3'-phosphatase | 4.2584 |
| LOC122526780 | uncharacterized LOC122526780 | 4.18375 |
| ARL4C | ADP-ribosylation factor-like 4C | 3.91452 |
| EGF | epidermal growth factor | 3.64945 |
| STIMATE | STIM activating enhancer | 3.57515 |
| SIRT3 | sirtuin 3 | 3.21313 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.17845 |
| SFTPB | surfactant protein B | 3.10693 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.0689 |
| WDR7 | WD repeat domain 7 | 2.9572 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | 2.95245 |
| ACP2 | acid phosphatase 2, lysosomal | 2.9476 |
| LCN2 | lipocalin 2 | 2.91075 |
| GPATCH8 | G patch domain containing 8 | 2.86775 |
| DCXR | dicarbonyl/L-xylulose reductase | 2.7159 |
| ZNF589 | zinc finger protein 589 | 2.68975 |
| GSTT2B | glutathione S-transferase theta 2B (gene/pseudogene) | 2.5858 |
| CCNF | cyclin F | 2.5801 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.5365 |
| SYT17 | synaptotagmin XVII | 2.479 |
| SLC75A1 | solute carrier family 75 member 1 | 2.4299 |
| CORO1A | coronin, actin binding protein, 1A | 2.4033 |
| MAT2B | methionine adenosyltransferase II, beta | 2.38635 |
| CHN1 | chimerin 1 | 2.36665 |
| B4GALT7 | xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 | 2.3261 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.31985 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | 2.3183 |
| TBP | TATA box binding protein | 2.31215 |
| CHEK2 | checkpoint kinase 2 | 2.28793 |
| GTF3C1 | general transcription factor IIIC, polypeptide 1, alpha 220kDa | 2.28447 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | 2.27225 |
| PLA2G2D | phospholipase A2, group IID | 2.2615 |
| AP2S1 | adaptor-related protein complex 2, sigma 1 subunit | 2.24463 |
| FPGS | folylpolyglutamate synthase | 2.21345 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.20405 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 2.20285 |
| TRIM68 | tripartite motif containing 68 | 2.1734 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 2.1582 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 2.0859 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 2.0795 |
| PIH1D1 | PIH1 domain containing 1 | 2.0744 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 2.0062 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -5.4102 |
| ADI1 | acireductone dioxygenase 1 | -5.28575 |
| MRPS2 | mitochondrial ribosomal protein S2 | -4.9672 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.66275 |
| VAT1 | vesicle amine transport 1 | -4.64025 |
| PCNA | proliferating cell nuclear antigen | -4.6007 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.63415 |
| MAP7 | microtubule-associated protein 7 | -3.5541 |
| CCNB1 | cyclin B1 | -3.42835 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.2221 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -3.1944 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -2.936 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.9334 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.69285 |
| FASTKD5 | FAST kinase domains 5 | -2.6433 |
| UPK3B | uroplakin 3B | -2.62385 |
| PAEP | progestagen-associated endometrial protein | -2.513 |
| RGS2 | regulator of G-protein signaling 2 | -2.5075 |
| RBM34 | RNA binding motif protein 34 | -2.42263 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -2.42145 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.3897 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -2.3864 |
| HOMER3 | homer scaffolding protein 3 | -2.37223 |
| TSLIG3A | tRNA splicing ligase complex subunit 3A | -2.351 |
| ITM2A | integral membrane protein 2A | -2.32097 |
| RNF113A | ring finger protein 113A | -2.30855 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | -2.30183 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.29043 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.28645 |
| KRT7 | keratin 7, type II | -2.23535 |
| FAT4 | FAT atypical cadherin 4 | -2.1707 |
| MAGEA8 | melanoma antigen family A8 | -2.1684 |
| MAPK6 | mitogen-activated protein kinase 6 | -2.13995 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.12285 |
| KRT10 | keratin 10, type I | -2.08592 |
| CSDC2 | cold shock domain containing C2, RNA binding | -2.07865 |
| NCK2 | NCK adaptor protein 2 | -2.03975 |
| ADAMTSL3 | ADAMTS-like 3 | -2.01 |
| CTSF | cathepsin F | -2.0087 |
| MRPL34 | mitochondrial ribosomal protein L34 | -2.00725 |
| DUSP10 | dual specificity phosphatase 10 | -2.00597 |
