CRCGN008_HEPG2_24H:J13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN008_HEPG2_24H:J13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 6.39855
PMM2 phosphomannomutase 2 5.67335
RPL39L ribosomal protein L39-like 5.0533
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.7465
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.66319
ABHD6 abhydrolase domain containing 6 4.26568
GATA3 GATA binding protein 3 4.09563
PRKCH protein kinase C, eta 4.08113
PEX11A peroxisomal biogenesis factor 11 alpha 3.98518
STK10 serine/threonine kinase 10 3.92247
EPN2 epsin 2 3.84868
RRAGA Ras-related GTP binding A 3.6302
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.59713
NMU neuromedin U 3.57755
SOCS2 suppressor of cytokine signaling 2 3.55075
RAB21 RAB21, member RAS oncogene family 3.40895
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.15583
EVL Enah/Vasp-like 3.0473
CYCS cytochrome c, somatic 3.02855
CCNF cyclin F 3.02765
HEBP1 heme binding protein 1 3.02745
JADE2 jade family PHD finger 2 3.00615
MAP7 microtubule-associated protein 7 2.9979
ZNF589 zinc finger protein 589 2.92937
RAD51C RAD51 paralog C 2.79638
GARRE1 granule associated Rac and RHOG effector 1 2.6817
CERS4 ceramide synthase 4 2.67455
GREM1 gremlin 1, DAN family BMP antagonist 2.55678
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 2.5449
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.5235
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.4707
CD2 CD2 molecule 2.45745
BPHL biphenyl hydrolase-like (serine hydrolase) 2.43645
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.41497
PDE2A phosphodiesterase 2A, cGMP-stimulated 2.4106
CD247 CD247 molecule 2.31875
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.29455
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 2.2674
RNF167 ring finger protein 167 2.2615
DNASE1L3 deoxyribonuclease I-like 3 2.2338
LPAR2 lysophosphatidic acid receptor 2 2.219
EPHA3 EPH receptor A3 2.15208
LPXN leupaxin 2.11315
IQGAP1 IQ motif containing GTPase activating protein 1 2.10992
ASTN1 astrotactin 1 2.10975
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.09998
ITPKB inositol-trisphosphate 3-kinase B 2.07835
CDK4 cyclin-dependent kinase 4 2.05935
KLRG1 killer cell lectin-like receptor subfamily G, member 1 2.0442
SNTG1 syntrophin, gamma 1 2.0409
LY9 lymphocyte antigen 9 2.0218
TTC1 tetratricopeptide repeat domain 1 2.0144
STX1A syntaxin 1A (brain) 2.0143

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -10.0
CASP7 caspase 7, apoptosis-related cysteine peptidase -7.5521
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.1027
OXA1L oxidase (cytochrome c) assembly 1-like -5.96215
CDC20 cell division cycle 20 -5.318
PCNA proliferating cell nuclear antigen -5.0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.64675
HLA-DMA major histocompatibility complex, class II, DM alpha -4.42455
ADI1 acireductone dioxygenase 1 -4.28185
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.88235
PRPF4 pre-mRNA processing factor 4 -3.56155
ARMCX5 armadillo repeat containing, X-linked 5 -3.2198
ACAA1 acetyl-CoA acyltransferase 1 -3.11975
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.94508
NT5C2 5'-nucleotidase, cytosolic II -2.57455
WASHC4 WASH complex subunit 4 -2.5436
CDC25B cell division cycle 25B -2.52815
SCCPDH saccharopine dehydrogenase (putative) -2.4783
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.45493
CNKSR1 connector enhancer of kinase suppressor of Ras 1 -2.4392
POLL polymerase (DNA directed), lambda -2.4266
NRIP1 nuclear receptor interacting protein 1 -2.33562
NGFR nerve growth factor receptor -2.26575
RBMS2 RNA binding motif, single stranded interacting protein 2 -2.2536
HSPA8 heat shock 70kDa protein 8 -2.24015
TBXAS1 thromboxane A synthase 1 (platelet) -2.2181
ZFPM1 zinc finger protein, FOG family member 1 -2.11245
P3H1 prolyl 3-hydroxylase 1 -2.1075
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -2.10068
NISCH nischarin -2.08735
UBE3C ubiquitin protein ligase E3C -2.05345
STEAP3 STEAP family member 3, metalloreductase -2.0323
ANK1 ankyrin 1, erythrocytic -2.03111
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -2.0132
TBC1D2 TBC1 domain family, member 2 -2.00925