CRCGN008_HEPG2_24H:J16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

93 genes differentially expressed following the CRCGN008_HEPG2_24H:J16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 5.81835
CHMP6 charged multivesicular body protein 6 5.69195
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0569
TAC4 tachykinin 4 (hemokinin) 5.0
RPL39L ribosomal protein L39-like 4.97705
RPP38 ribonuclease P/MRP 38kDa subunit 4.88705
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.6815
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.65915
E2F2 E2F transcription factor 2 4.61845
CBR3 carbonyl reductase 3 4.6148
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 4.37545
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.3691
EGF epidermal growth factor 4.3533
STIMATE STIM activating enhancer 4.25825
SNAP25 synaptosomal-associated protein, 25kDa 3.6742
CYCS cytochrome c, somatic 3.62955
TIAM1 T-cell lymphoma invasion and metastasis 1 3.40707
NMU neuromedin U 3.1959
RRAGA Ras-related GTP binding A 3.1481
PRKCH protein kinase C, eta 2.95292
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.92813
SSBP2 single-stranded DNA binding protein 2 2.8085
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.78982
GRPR gastrin-releasing peptide receptor 2.6823
EPHA3 EPH receptor A3 2.61405
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.60845
RGS19 regulator of G-protein signaling 19 2.5971
ZNF286A zinc finger protein 286A 2.56105
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.50995
SMAD3 SMAD family member 3 2.44228
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 2.42005
OR10H3 olfactory receptor, family 10, subfamily H, member 3 2.3835
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.36926
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.3364
NOCT nocturnin 2.27765
SLC46A3 solute carrier family 46, member 3 2.2755
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.2701
CLDN16 claudin 16 2.2654
CSRNP3 cysteine-serine-rich nuclear protein 3 2.2459
FGF16 fibroblast growth factor 16 2.2448
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.23692
PSG11 pregnancy specific beta-1-glycoprotein 11 2.22735
CD101 CD101 molecule 2.21465
CDON cell adhesion associated, oncogene regulated 2.2099
AXIN1 axin 1 2.20755
MC5R melanocortin 5 receptor 2.19
ERCC4 excision repair cross-complementation group 4 2.14765
MTNAP1 mitochondrial nucleoid associated protein 1 2.14645
TUBA8 tubulin, alpha 8 2.14295
WDTC1 WD and tetratricopeptide repeats 1 2.13383
CHRM5 cholinergic receptor, muscarinic 5 2.1224
LALBA lactalbumin, alpha- 2.0949
AMBN ameloblastin (enamel matrix protein) 2.07335
MCHR1 melanin-concentrating hormone receptor 1 2.055
IL22 interleukin 22 2.054
PDZD7 PDZ domain containing 7 2.04535
USP6NL USP6 N-terminal like 2.0412
GML glycosylphosphatidylinositol anchored molecule like 2.03785
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.0305
LOC124906280 uncharacterized LOC124906280 2.02955
FSD1 fibronectin type III and SPRY domain containing 1 2.02605
G6PC2 glucose-6-phosphatase, catalytic, 2 2.02165
ANGPTL8 angiopoietin like 8 2.0206
CSN1S1 casein alpha s1 2.01625
SH2D3C SH2 domain containing 3C 2.01625
PCDHA9 protocadherin alpha 9 2.00795
PSIP1 PC4 and SFRS1 interacting protein 1 2.00488
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.00145

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -8.3987
TUBB6 tubulin, beta 6 class V -5.15305
MRPS2 mitochondrial ribosomal protein S2 -5.1465
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0711
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -5.0543
TLCD3A TLC domain containing 3A -4.9135
FGFR4 fibroblast growth factor receptor 4 -4.0592
BLCAP bladder cancer associated protein -3.99065
MTFR1 mitochondrial fission regulator 1 -3.94587
RGS2 regulator of G-protein signaling 2 -3.64325
PRPF4 pre-mRNA processing factor 4 -3.6017
CCNB2 cyclin B2 -3.5554
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.69605
CHIC2 cysteine-rich hydrophobic domain 2 -2.63325
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.6128
NRIP1 nuclear receptor interacting protein 1 -2.59545
IP6K1 inositol hexakisphosphate kinase 1 -2.22795
SPAG4 sperm associated antigen 4 -2.12215
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.11147
RXRA retinoid X receptor, alpha -2.11102
AKAP8 A kinase (PRKA) anchor protein 8 -2.08282
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.0794
TKTL1 transketolase-like 1 -2.0371
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.01305
SEC16A SEC16 homolog A (S. cerevisiae) -2.0127