CRCGN008_HEPG2_24H:J17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN008_HEPG2_24H:J17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HLA-DMA major histocompatibility complex, class II, DM alpha 5.4565
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.4012
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.92995
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.79255
CCDC85B coiled-coil domain containing 85B 4.6965
ADGRE5 adhesion G protein-coupled receptor E5 4.67125
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.4226
HLA-DRA major histocompatibility complex, class II, DR alpha 4.16648
SSBP2 single-stranded DNA binding protein 2 4.11355
SNAP25 synaptosomal-associated protein, 25kDa 4.10833
GPER1 G protein-coupled estrogen receptor 1 4.08642
PEX11A peroxisomal biogenesis factor 11 alpha 3.87277
VGLL4 vestigial-like family member 4 3.54608
CCL2 chemokine (C-C motif) ligand 2 3.39145
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.30055
PRR15L proline rich 15-like 3.08955
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.0534
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.9558
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.81718
GSTZ1 glutathione S-transferase zeta 1 2.7676
BPIFA1 BPI fold containing family A, member 1 2.4378
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.36405
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough 2.29395
FGF4 fibroblast growth factor 4 2.2602
WASF3 WAS protein family, member 3 2.2594
SCRN1 secernin 1 2.24175
EPHA3 EPH receptor A3 2.17035
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.16541
PRELID3A PRELI domain containing 3A 2.1528
WDTC1 WD and tetratricopeptide repeats 1 2.13315
FBP1 fructose-1,6-bisphosphatase 1 2.12945
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.09795
CRYGB crystallin, gamma B 2.0794
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.0468
STK26 serine/threonine protein kinase 26 2.03425
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.0026

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.6081
OXA1L oxidase (cytochrome c) assembly 1-like -6.3438
UGDH UDP-glucose 6-dehydrogenase -5.13795
TLCD3A TLC domain containing 3A -5.12155
TRIB3 tribbles pseudokinase 3 -4.8087
NRIP1 nuclear receptor interacting protein 1 -4.7426
LDHD lactate dehydrogenase D -4.66275
ANKRD10 ankyrin repeat domain 10 -4.6515
PCNA proliferating cell nuclear antigen -4.6007
NT5DC2 5'-nucleotidase domain containing 2 -4.4187
FASTKD5 FAST kinase domains 5 -3.7213
MAP7 microtubule-associated protein 7 -3.71273
VDAC1 voltage-dependent anion channel 1 -3.36725
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.35555
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.2871
CCNB2 cyclin B2 -3.28455
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.21698
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.1271
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.6085
CA2 carbonic anhydrase II -2.307
DUSP14 dual specificity phosphatase 14 -2.278
PCGF3 polycomb group ring finger 3 -2.24283
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.16605
PRODH proline dehydrogenase (oxidase) 1 -2.15695
SPRR1A small proline-rich protein 1A -2.1521
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.0833
LOC102724428 serine/threonine-protein kinase SIK1 -2.0188