CRCGN008_HEPG2_24H:J19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monoethylhexylphthalate 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

137 genes differentially expressed following the CRCGN008_HEPG2_24H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.82195
ADRB2 adrenoceptor beta 2, surface 5.4206
HLA-DMA major histocompatibility complex, class II, DM alpha 5.39965
TATDN2 TatD DNase domain containing 2 5.2061
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0549
CCL2 chemokine (C-C motif) ligand 2 4.9174
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.7595
CHMP6 charged multivesicular body protein 6 4.6161
TBC1D10C TBC1 domain family, member 10C 4.59535
BACE2 beta-site APP-cleaving enzyme 2 4.5868
MCUR1 mitochondrial calcium uniporter regulator 1 4.49
MOK MOK protein kinase 4.4308
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.3936
PPARG peroxisome proliferator-activated receptor gamma 4.38875
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.18496
ARL4C ADP-ribosylation factor-like 4C 4.14622
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.99995
HOXA10 homeobox A10 3.93872
LCN2 lipocalin 2 3.62425
AXIN1 axin 1 3.5551
SNAP25 synaptosomal-associated protein, 25kDa 3.53548
MAP7 microtubule-associated protein 7 3.41225
RRAGA Ras-related GTP binding A 3.2495
PRKCH protein kinase C, eta 2.97825
C2CD2 C2 calcium-dependent domain containing 2 2.9584
PLSCR1 phospholipid scramblase 1 2.95592
RPA3 replication protein A3, 14kDa 2.8636
TAC4 tachykinin 4 (hemokinin) 2.788
CHN1 chimerin 1 2.76695
CCNF cyclin F 2.61797
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 2.58315
JADE2 jade family PHD finger 2 2.58008
C4A complement component 4A (Rodgers blood group) 2.54838
ANO10 anoctamin 10 2.54785
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.5043
ERMP1 endoplasmic reticulum metallopeptidase 1 2.46535
SCRN1 secernin 1 2.445
HEBP1 heme binding protein 1 2.4395
NCALD neurocalcin delta 2.388
CORO1A coronin, actin binding protein, 1A 2.38415
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.36738
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.32427
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.30653
NPTX1 neuronal pentraxin I 2.28095
DCLRE1C DNA cross-link repair 1C 2.27635
MRPS10 mitochondrial ribosomal protein S10 2.26895
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.24563
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.23525
USP6NL USP6 N-terminal like 2.23275
CKLF-CMTM1 CKLF-CMTM1 readthrough 2.21742
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.2131
FXYD2 FXYD domain containing ion transport regulator 2 2.19462
GPN3 GPN-loop GTPase 3 2.19445
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.1891
HEBP2 heme binding protein 2 2.171
VCAM1 vascular cell adhesion molecule 1 2.1698
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.1678
CEMIP2 cell migration inducing hyaluronidase 2 2.1597
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.11895
MDC1 mediator of DNA-damage checkpoint 1 2.10438
HBG1 hemoglobin, gamma A 2.09993
CENPT centromere protein T 2.09965
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 2.0799
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 2.07125
CCDC85B coiled-coil domain containing 85B 2.05645
DYNLRB1 dynein, light chain, roadblock-type 1 2.05433
SLC2A4RG SLC2A4 regulator 2.0519
TRIP6 thyroid hormone receptor interactor 6 2.0423
SKIC2 SKI2 subunit of superkiller complex 2.0392
VEGFB vascular endothelial growth factor B 2.03695
TEX30 testis expressed 30 2.03105
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 2.0238
AGO1 argonaute RISC catalytic component 1 2.0122
PRMT7 protein arginine methyltransferase 7 2.01035

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.0034
ARID5B AT rich interactive domain 5B (MRF1-like) -8.5227
OXA1L oxidase (cytochrome c) assembly 1-like -6.5343
KDM3A lysine (K)-specific demethylase 3A -5.89215
NGRN neugrin, neurite outgrowth associated -5.30015
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.12385
CD320 CD320 molecule -4.98315
CDC20 cell division cycle 20 -4.6933
TLCD3A TLC domain containing 3A -4.6638
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.61585
TUBB6 tubulin, beta 6 class V -4.48725
RGS2 regulator of G-protein signaling 2 -4.1171
CXCL2 chemokine (C-X-C motif) ligand 2 -3.843
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.68535
TM9SF3 transmembrane 9 superfamily member 3 -3.62695
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -3.60965
GNAS GNAS complex locus -3.57895
CCNB1 cyclin B1 -3.27465
CHIC2 cysteine-rich hydrophobic domain 2 -3.2576
CTNND1 catenin (cadherin-associated protein), delta 1 -3.23783
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.17432
FOS FBJ murine osteosarcoma viral oncogene homolog -3.1166
ACVRL1 activin A receptor type II-like 1 -2.8958
ETHE1 ethylmalonic encephalopathy 1 -2.76585
SESN1 sestrin 1 -2.7418
DET1 de-etiolated homolog 1 (Arabidopsis) -2.73165
IGSF1 immunoglobulin superfamily, member 1 -2.7308
PUDP pseudouridine 5'-phosphatase -2.69475
SOX11 SRY (sex determining region Y)-box 11 -2.65545
FASTKD5 FAST kinase domains 5 -2.545
DERA deoxyribose-phosphate aldolase (putative) -2.49325
PNMA8A PNMA family member 8A -2.42775
FBXL12 F-box and leucine-rich repeat protein 12 -2.3609
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -2.3579
CRABP1 cellular retinoic acid binding protein 1 -2.3474
SPAG4 sperm associated antigen 4 -2.33125
GABARAP GABA(A) receptor-associated protein -2.30535
NRIP1 nuclear receptor interacting protein 1 -2.29058
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 -2.2517
GPA33 glycoprotein A33 (transmembrane) -2.2421
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.2369
ZFHX4 zinc finger homeobox 4 -2.23415
RGS5 regulator of G-protein signaling 5 -2.21575
ANKRD46 ankyrin repeat domain 46 -2.20215
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.19635
FLT4 fms-related tyrosine kinase 4 -2.1434
MGAT4C MGAT4 family, member C -2.14035
GIMAP6 GTPase, IMAP family member 6 -2.1213
LRRC8E leucine rich repeat containing 8 family, member E -2.10685
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 -2.09695
CD300C CD300c molecule -2.0904
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.08883
FLT1 fms-related tyrosine kinase 1 -2.08687
EPHB2 EPH receptor B2 -2.08612
COL9A2 collagen, type IX, alpha 2 -2.0855
DPYSL4 dihydropyrimidinase-like 4 -2.08098
RPH3AL rabphilin 3A-like (without C2 domains) -2.07985
LRRC47 leucine rich repeat containing 47 -2.06755
PSEN1 presenilin 1 -2.04067
C5 complement component 5 -2.03525
GATA6 GATA binding protein 6 -2.0337
LEFTY1 left-right determination factor 1 -2.0253
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -2.0007