CRCGN008_HEPG2_24H:J20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monoethylhexylphthalate 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN008_HEPG2_24H:J20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 5.25815
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.5842
MAMLD1 mastermind-like domain containing 1 4.43345
CBR3 carbonyl reductase 3 4.3373
LOC122526780 uncharacterized LOC122526780 4.29575
CCNH cyclin H 4.0195
SMIM40 small integral membrane protein 40 3.98625
VGLL4 vestigial-like family member 4 3.82203
KLHL9 kelch-like family member 9 3.72235
MEST mesoderm specific transcript 3.50385
ZNF589 zinc finger protein 589 3.1898
TRIM13 tripartite motif containing 13 2.9772
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.92215
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.83418
CORO1A coronin, actin binding protein, 1A 2.76235
FSD1 fibronectin type III and SPRY domain containing 1 2.56295
CREB1 cAMP responsive element binding protein 1 2.43937
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.39915
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.3105
HEBP1 heme binding protein 1 2.1085
RMDN3 regulator of microtubule dynamics 3 2.05255
CTSL cathepsin L 2.0178

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
RPN1 ribophorin I -5.419
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8195
SLC35F2 solute carrier family 35, member F2 -4.7955
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.32702
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.7247
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -3.3078
OXA1L oxidase (cytochrome c) assembly 1-like -3.281
APOE apolipoprotein E -3.26203
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.25775
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.9852
COPG1 coatomer protein complex, subunit gamma 1 -2.97295
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.9415
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.92565
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.70715
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.4918
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.49135
SBNO1 strawberry notch homolog 1 (Drosophila) -2.45925
CHEK1 checkpoint kinase 1 -2.42213
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.36235
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.32705
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.3041
CSF1R colony stimulating factor 1 receptor -2.3039
KDM3B lysine (K)-specific demethylase 3B -2.22835
RBBP4 retinoblastoma binding protein 4 -2.13243
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) -2.12015
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa -2.1028
FOXO4 forkhead box O4 -2.0912
SRSF9 serine/arginine-rich splicing factor 9 -2.0793
KRT4 keratin 4, type II -2.0772
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.06537
PRSS23 protease, serine, 23 -2.0548
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.004