CRCGN008_HEPG2_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description monoethylhexylphthalate 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

116 genes differentially expressed following the CRCGN008_HEPG2_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.1641
PPARG peroxisome proliferator-activated receptor gamma 5.0379
CBR3 carbonyl reductase 3 4.913
IDE insulin-degrading enzyme 4.7918
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.7395
MYLK myosin light chain kinase 4.5663
ARL4C ADP-ribosylation factor-like 4C 4.5585
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.5081
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.46525
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.98787
VGLL4 vestigial-like family member 4 3.64402
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.43235
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.6594
CTSL cathepsin L 2.60225
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.38505
HEBP1 heme binding protein 1 2.3243
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.27768
LOC122526780 uncharacterized LOC122526780 2.2714
PRC1 protein regulator of cytokinesis 1 2.1377
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.136
NIPSNAP2 nipsnap homolog 2 2.1255
ANKMY2 ankyrin repeat and MYND domain containing 2 2.0989
WASF3 WAS protein family, member 3 2.00705
RNASE4 ribonuclease, RNase A family, 4 2.00402

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.2303
TUBB6 tubulin, beta 6 class V -5.07015
NRIP1 nuclear receptor interacting protein 1 -4.94173
GNAS GNAS complex locus -4.91458
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.5831
CD320 CD320 molecule -4.54955
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.49415
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.38255
FASTKD5 FAST kinase domains 5 -3.90475
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.83975
MAP7 microtubule-associated protein 7 -3.78253
CLIC4 chloride intracellular channel 4 -2.96568
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.83665
TMC7 transmembrane channel-like 7 -2.706
DDIT4 DNA-damage-inducible transcript 4 -2.698
TXNDC9 thioredoxin domain containing 9 -2.66587
GRIA4 glutamate receptor, ionotropic, AMPA 4 -2.64605
CDC25B cell division cycle 25B -2.63115
RNF167 ring finger protein 167 -2.5905
GRIA3 glutamate receptor, ionotropic, AMPA 3 -2.5878
CTNNA3 catenin (cadherin-associated protein), alpha 3 -2.48415
BMP15 bone morphogenetic protein 15 -2.4757
RASL10A RAS-like, family 10, member A -2.45995
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.41623
FFAR2 free fatty acid receptor 2 -2.404
CCNH cyclin H -2.3569
OMG oligodendrocyte myelin glycoprotein -2.3523
HGFAC HGF activator -2.34985
COL19A1 collagen, type XIX, alpha 1 -2.3383
HSPA8 heat shock 70kDa protein 8 -2.32362
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.285
MAGEB4 melanoma antigen family B4 -2.27925
NSUN7 NOP2/Sun domain family, member 7 -2.27135
EDDM3B epididymal protein 3B -2.2615
UIMC1 ubiquitin interaction motif containing 1 -2.2053
IL21 interleukin 21 -2.18725
SCG3 secretogranin III -2.1835
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -2.1822
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.178
TTLL7 tubulin tyrosine ligase-like family member 7 -2.17675
ELSPBP1 epididymal sperm binding protein 1 -2.1761
BSN bassoon presynaptic cytomatrix protein -2.1754
SH2D3C SH2 domain containing 3C -2.16995
FGF12 fibroblast growth factor 12 -2.16803
AKAP6 A kinase (PRKA) anchor protein 6 -2.16698
CRISP1 cysteine-rich secretory protein 1 -2.15695
STXBP5L syntaxin binding protein 5-like -2.1514
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -2.15135
PLAAT1 phospholipase A and acyltransferase 1 -2.14348
IFNA7 interferon, alpha 7 -2.13205
POU3F2 POU class 3 homeobox 2 -2.1175
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -2.1101
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -2.108
ERVMER34-1 endogenous retrovirus group MER34, member 1 -2.1074
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -2.0993
ADRB1 adrenoceptor beta 1 -2.0874
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -2.0862
GRIK3 glutamate receptor, ionotropic, kainate 3 -2.07945
NKX2-2 NK2 homeobox 2 -2.0739
DRD1 dopamine receptor D1 -2.07215
SLITRK2 SLIT and NTRK-like family, member 2 -2.06895
USP27X ubiquitin specific peptidase 27, X-linked -2.06765
CSF3 colony stimulating factor 3 (granulocyte) -2.06705
FAM110B family with sequence similarity 110, member B -2.0648
PYGO1 pygopus family PHD finger 1 -2.0637
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.06275
SMCP sperm mitochondria-associated cysteine-rich protein -2.0596
OCLN occludin -2.0566
RBM15 RNA binding motif protein 15 -2.05632
H3-4 H3.4 histone, cluster member -2.0547
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.05405
GUCY2F guanylate cyclase 2F, retinal -2.0523
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) -2.05115
OTOR otoraplin -2.0498
HRH4 histamine receptor H4 -2.04735
MRNIP MRN complex interacting protein -2.04265
TEC tec protein tyrosine kinase -2.04225
PRSS50 protease, serine, 50 -2.0408
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -2.0367
STAMBP STAM binding protein -2.03595
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.03485
OR1E1 olfactory receptor, family 1, subfamily E, member 1 -2.03455
TDRD1 tudor domain containing 1 -2.03425
TRPS1 trichorhinophalangeal syndrome I -2.03135
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) -2.02875
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled -2.02265
TAAR5 trace amine associated receptor 5 -2.02
PKP4 plakophilin 4 -2.01569
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -2.0122
CAPZB capping protein (actin filament) muscle Z-line, beta -2.00878
TDRKH tudor and KH domain containing -2.00847
BCAN brevican -2.0008