CRCGN008_HEPG2_24H:K04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-4-aminoazobenzene 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

92 genes differentially expressed following the CRCGN008_HEPG2_24H:K04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 5.56295
AMDHD2 amidohydrolase domain containing 2 5.31225
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.14345
TESK1 testis-specific kinase 1 5.0529
EGF epidermal growth factor 4.95235
UBQLN2 ubiquilin 2 4.8898
CDPF1 cysteine-rich, DPF motif domain containing 1 4.84205
MAMLD1 mastermind-like domain containing 1 4.80305
PNKP polynucleotide kinase 3'-phosphatase 4.68545
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 4.53805
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.41945
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.4177
GPER1 G protein-coupled estrogen receptor 1 4.31975
TIMP2 TIMP metallopeptidase inhibitor 2 4.17055
ARL4C ADP-ribosylation factor-like 4C 4.04183
TBC1D31 TBC1 domain family, member 31 3.9828
EVL Enah/Vasp-like 3.9145
ABHD4 abhydrolase domain containing 4 3.79525
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 3.32293
CYCS cytochrome c, somatic 3.30135
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.81198
HEBP1 heme binding protein 1 2.73545
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.72365
PCID2 PCI domain containing 2 2.6177
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.59125
LPAR2 lysophosphatidic acid receptor 2 2.56248
VGLL4 vestigial-like family member 4 2.54612
TXNL4B thioredoxin-like 4B 2.47815
KLHL9 kelch-like family member 9 2.36685
ZNF589 zinc finger protein 589 2.36187
NECAB3 N-terminal EF-hand calcium binding protein 3 2.35305
FDXR ferredoxin reductase 2.27955
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.27365
HSPB3 heat shock 27kDa protein 3 2.2416
ZHX2 zinc fingers and homeoboxes 2 2.224
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.1469
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 2.13895
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 2.12355
STK10 serine/threonine kinase 10 2.10827
NEUROG2 neurogenin 2 2.062
APOBR apolipoprotein B receptor 2.03685
TXNRD1 thioredoxin reductase 1 2.02015

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.63035
C2CD5 C2 calcium-dependent domain containing 5 -5.4772
ISOC1 isochorismatase domain containing 1 -5.4526
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.1238
ADI1 acireductone dioxygenase 1 -5.0797
KDM3A lysine (K)-specific demethylase 3A -5.05685
ZNF586 zinc finger protein 586 -5.05665
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.0
LDHD lactate dehydrogenase D -4.93295
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.8821
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.66405
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.66275
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.5045
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.43105
ILK integrin-linked kinase -3.9644
NGRN neugrin, neurite outgrowth associated -3.88585
FASTKD5 FAST kinase domains 5 -3.6989
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.62755
PTPRK protein tyrosine phosphatase, receptor type, K -3.5567
CCNB2 cyclin B2 -3.52345
OXA1L oxidase (cytochrome c) assembly 1-like -3.39
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.37135
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -3.35652
HEATR1 HEAT repeat containing 1 -3.1299
ELOVL1 ELOVL fatty acid elongase 1 -2.86737
LEFTY2 left-right determination factor 2 -2.73165
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -2.64385
PROS1 protein S (alpha) -2.45565
CD40LG CD40 ligand -2.44815
RABGAP1L RAB GTPase activating protein 1-like -2.43083
AK4 adenylate kinase 4 -2.38745
FOXJ1 forkhead box J1 -2.3764
PAQR6 progestin and adipoQ receptor family member VI -2.3717
RNF167 ring finger protein 167 -2.35545
RLF rearranged L-myc fusion -2.3317
GP1BA glycoprotein Ib (platelet), alpha polypeptide -2.28215
RBM7 RNA binding motif protein 7 -2.2378
C5 complement component 5 -2.1706
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.15985
RERGL RERG/RAS-like -2.11765
RTN3 reticulon 3 -2.09545
OARD1 O-acyl-ADP-ribose deacylase 1 -2.09055
DNAH6 dynein, axonemal, heavy chain 6 -2.07385
FURIN furin (paired basic amino acid cleaving enzyme) -2.0716
RESF1 retroelement silencing factor 1 -2.05755
ASTE1 asteroid homolog 1 (Drosophila) -2.0465
ITGB1BP1 integrin beta 1 binding protein 1 -2.0459
GATA1 GATA binding protein 1 (globin transcription factor 1) -2.0348
ZNF136 zinc finger protein 136 -2.0058