CRCGN008_HEPG2_24H:K05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-4-aminoazobenzene 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN008_HEPG2_24H:K05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
GSTZ1 glutathione S-transferase zeta 1 5.47205
CDPF1 cysteine-rich, DPF motif domain containing 1 5.2105
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.4797
SSBP2 single-stranded DNA binding protein 2 4.063
NOSIP nitric oxide synthase interacting protein 4.0399
GPER1 G protein-coupled estrogen receptor 1 3.80367
PRR15L proline rich 15-like 3.7125
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.33395
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.23235
GPATCH8 G patch domain containing 8 3.08505
ZNF589 zinc finger protein 589 2.867
HEBP1 heme binding protein 1 2.80065
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 2.5591
CCNF cyclin F 2.55323
TBP TATA box binding protein 2.4941
ADAT1 adenosine deaminase, tRNA-specific 1 2.4374
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.39195
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.3563
SKIC8 SKI8 subunit of superkiller complex 2.32117
RB1 retinoblastoma 1 2.30245
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.2995
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.28705
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 2.28325
APEH acylaminoacyl-peptide hydrolase 2.27155
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.2608
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.19903
BIRC2 baculoviral IAP repeat containing 2 2.1589
ANKRD49 ankyrin repeat domain 49 2.1409
SIRT7 sirtuin 7 2.1347
CENPX centromere protein X 2.0607
SMIM5 small integral membrane protein 5 2.05137
STXBP2 syntaxin binding protein 2 2.0354
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 2.01543
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.0041

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.79344
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -4.68045
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -4.6333
TLCD3A TLC domain containing 3A -4.4606
YME1L1 YME1-like 1 ATPase -4.09715
PRPF4 pre-mRNA processing factor 4 -3.75215
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.3046
OXA1L oxidase (cytochrome c) assembly 1-like -3.20495
AKR1D1 aldo-keto reductase family 1, member D1 -3.1263
LPA lipoprotein, Lp(a) -3.0687
ATP5F1E ATP synthase F1 subunit epsilon -3.00515
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.905
CCNB1 cyclin B1 -2.82175
CCNB2 cyclin B2 -2.74565
GYS2 glycogen synthase 2 (liver) -2.73755
AFAP1 actin filament associated protein 1 -2.68475
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.61585
APOF apolipoprotein F -2.54065
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.44662
KIF5B kinesin family member 5B -2.44242
GID4 GID complex subunit 4 -2.4411
RPN2 ribophorin II -2.41362
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -2.3532
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 -2.33085
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -2.31685
RPL3 ribosomal protein L3 -2.31433
HNMT histamine N-methyltransferase -2.31333
FBXL12 F-box and leucine-rich repeat protein 12 -2.31265
FAM149A family with sequence similarity 149, member A -2.23753
ZW10 zw10 kinetochore protein -2.2346
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -2.22975
NLGN4Y neuroligin 4, Y-linked -2.2255
AFM afamin -2.2222
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.20998
PRODH2 proline dehydrogenase (oxidase) 2 -2.20925
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.20175
MSRB2 methionine sulfoxide reductase B2 -2.18928
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.18375
RAB15 RAB15, member RAS oncogene family -2.1713
ASXL3 additional sex combs like transcriptional regulator 3 -2.16
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.13591
GPR153 G protein-coupled receptor 153 -2.11933
RDH16 retinol dehydrogenase 16 (all-trans) -2.11505
KCTD20 potassium channel tetramerization domain containing 20 -2.11375
H3-3A H3.3 histone A -2.09561
PLGLB2 plasminogen-like B2 -2.07052
MORF4L2 mortality factor 4 like 2 -2.06795
PEX5L peroxisomal biogenesis factor 5-like -2.06095
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.0562
RPL30 ribosomal protein L30 -2.0418
SBDS Shwachman-Bodian-Diamond syndrome -2.03705
YBX1 Y box binding protein 1 -2.02023
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.01455
C4BPB complement component 4 binding protein, beta -2.0054
NSUN7 NOP2/Sun domain family, member 7 -2.0035