CRCGN008_HEPG2_24H:K06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-4-aminoazobenzene 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN008_HEPG2_24H:K06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
SQOR sulfide quinone oxidoreductase 5.3179
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.13385
ALDOC aldolase C, fructose-bisphosphate 4.9866
CARMIL1 capping protein regulator and myosin 1 linker 1 4.9635
SNAP25 synaptosomal-associated protein, 25kDa 4.8539
BACE2 beta-site APP-cleaving enzyme 2 4.75235
JADE2 jade family PHD finger 2 4.75128
PPARG peroxisome proliferator-activated receptor gamma 4.73125
LYN LYN proto-oncogene, Src family tyrosine kinase 4.66697
MYLK myosin light chain kinase 4.643
LCN2 lipocalin 2 4.4915
FCHO1 FCH domain only 1 3.84645
CBR3 carbonyl reductase 3 3.73595
HDGFL3 HDGF like 3 3.58939
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.355
CD40 CD40 molecule, TNF receptor superfamily member 5 3.25226
PRR15L proline rich 15-like 3.18385
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 3.01733
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.99905
ABHD6 abhydrolase domain containing 6 2.96463
TBP TATA box binding protein 2.94345
CCNA1 cyclin A1 2.92525
CEP57 centrosomal protein 57kDa 2.84417
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.7777
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.75875
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.74005
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.72785
IFI44L interferon-induced protein 44-like 2.7114
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.63265
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.59545
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.5657
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.4988
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.4739
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.46235
CHN1 chimerin 1 2.45735
IFI44 interferon-induced protein 44 2.40373
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.3191
TFF1 trefoil factor 1 2.30435
MX1 MX dynamin-like GTPase 1 2.29265
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.26627
MX2 MX dynamin-like GTPase 2 2.24455
GSTZ1 glutathione S-transferase zeta 1 2.2421
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.1545
RSAD2 radical S-adenosyl methionine domain containing 2 2.11725
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.10535
CCL4 chemokine (C-C motif) ligand 4 2.10345
SNRPC small nuclear ribonucleoprotein polypeptide C 2.0478
RPS27L ribosomal protein S27-like 2.042
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.0185
PHF11 PHD finger protein 11 2.01165

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.45225
CDC20 cell division cycle 20 -5.0
TUBB6 tubulin, beta 6 class V -4.78095
HMG20B high mobility group 20B -4.25432
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.92705
RGS2 regulator of G-protein signaling 2 -3.924
NGRN neugrin, neurite outgrowth associated -3.85485
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.7242
CLIC4 chloride intracellular channel 4 -3.54155
SPAG4 sperm associated antigen 4 -3.46895
OXA1L oxidase (cytochrome c) assembly 1-like -3.1742
TOR1A torsin family 1, member A (torsin A) -2.9257
CHIC2 cysteine-rich hydrophobic domain 2 -2.80445
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.71618
NLRP4 NLR family, pyrin domain containing 4 -2.5276
INPPL1 inositol polyphosphate phosphatase-like 1 -2.5248
MCOLN1 mucolipin 1 -2.466
CCNB1 cyclin B1 -2.4422
DNAI4 dynein axonemal intermediate chain 4 -2.3588
SNX11 sorting nexin 11 -2.33627
PRPF4 pre-mRNA processing factor 4 -2.30308
CAPN1 calpain 1, (mu/I) large subunit -2.29965
HSPA8 heat shock 70kDa protein 8 -2.22825
EDN1 endothelin 1 -2.17835
SLC35B1 solute carrier family 35, member B1 -2.15555
TMSB4X thymosin beta 4, X-linked -2.1449
DDIT4 DNA-damage-inducible transcript 4 -2.13595
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -2.13035
SZT2 seizure threshold 2 homolog (mouse) -2.12372
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.061
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.05755
POMT1 protein-O-mannosyltransferase 1 -2.0287
RBM15B RNA binding motif protein 15B -2.01815
DNM1 dynamin 1 -2.0045