| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 10.09 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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97 genes differentially expressed following the CRCGN008_HEPG2_24H:K14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HOXA10 | homeobox A10 | 9.73548 |
| MOK | MOK protein kinase | 7.4231 |
| CCL2 | chemokine (C-C motif) ligand 2 | 6.93995 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.58 |
| JADE2 | jade family PHD finger 2 | 5.3585 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.1693 |
| E2F2 | E2F transcription factor 2 | 4.61845 |
| ARL4C | ADP-ribosylation factor-like 4C | 4.30755 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.16885 |
| PRR15L | proline rich 15-like | 3.9817 |
| HOXA10-HOXA9 | HOXA10-HOXA9 readthrough | 3.97905 |
| HOXA11 | homeobox A11 | 3.75495 |
| NOSIP | nitric oxide synthase interacting protein | 3.58025 |
| SH3D19 | SH3 domain containing 19 | 3.465 |
| EGF | epidermal growth factor | 3.45015 |
| HEBP1 | heme binding protein 1 | 3.03895 |
| PLSCR3 | phospholipid scramblase 3 | 2.98393 |
| LCN2 | lipocalin 2 | 2.93 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.86045 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.83422 |
| PIH1D1 | PIH1 domain containing 1 | 2.8298 |
| SCRIB | scribbled planar cell polarity protein | 2.81805 |
| MAEA | macrophage erythroblast attacher | 2.7156 |
| TBP | TATA box binding protein | 2.69255 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 2.69085 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | 2.64155 |
| AZU1 | azurocidin 1 | 2.59825 |
| SIRT3 | sirtuin 3 | 2.57633 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.56225 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 2.52842 |
| CETN3 | centrin, EF-hand protein, 3 | 2.5181 |
| ECD | ecdysoneless homolog (Drosophila) | 2.4831 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 2.4608 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 2.41505 |
| EPHA3 | EPH receptor A3 | 2.34053 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 2.3114 |
| CTRB1 | chymotrypsinogen B1 | 2.27055 |
| BCL7C | B-cell CLL/lymphoma 7C | 2.2698 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.20855 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.20598 |
| HDAC3 | histone deacetylase 3 | 2.19595 |
| CTDP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 | 2.1659 |
| CYCS | cytochrome c, somatic | 2.1627 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.1576 |
| ELANE | elastase, neutrophil expressed | 2.14485 |
| WRN | Werner syndrome, RecQ helicase-like | 2.12055 |
| INS | insulin | 2.09805 |
| EPHB4 | EPH receptor B4 | 2.0765 |
| ZNF556 | zinc finger protein 556 | 2.0746 |
| TDP1 | tyrosyl-DNA phosphodiesterase 1 | 2.04815 |
| NUP93 | nucleoporin 93kDa | 2.03545 |
| TTC27 | tetratricopeptide repeat domain 27 | 2.0335 |
| SLC75A1 | solute carrier family 75 member 1 | 2.02405 |
| TXNL4B | thioredoxin-like 4B | 2.00535 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -5.80855 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -5.6324 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -5.5316 |
| CDC20 | cell division cycle 20 | -5.33725 |
| MRPS2 | mitochondrial ribosomal protein S2 | -5.2318 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.19825 |
| SLC35F2 | solute carrier family 35, member F2 | -5.03985 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -5.03985 |
| CCDC86 | coiled-coil domain containing 86 | -4.89945 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -4.5619 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -4.1902 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -4.02335 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.8772 |
| TLCD3A | TLC domain containing 3A | -3.6763 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -3.5609 |
| GNAS | GNAS complex locus | -3.54301 |
| CCNB1 | cyclin B1 | -3.1781 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -3.0206 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -2.95325 |
| NLRP4 | NLR family, pyrin domain containing 4 | -2.6967 |
| TCTN1 | tectonic family member 1 | -2.6438 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.64165 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.64068 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.62055 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -2.39495 |
| CTSZ | cathepsin Z | -2.3738 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | -2.3314 |
| SLC6A1 | solute carrier family 6 (neurotransmitter transporter), member 1 | -2.27425 |
| PLXDC2 | plexin domain containing 2 | -2.2684 |
| ADAMTSL3 | ADAMTS-like 3 | -2.2654 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.2624 |
| RBM34 | RNA binding motif protein 34 | -2.24103 |
| ATF5 | activating transcription factor 5 | -2.1685 |
| GABRB1 | gamma-aminobutyric acid (GABA) A receptor, beta 1 | -2.1567 |
| RABGAP1L | RAB GTPase activating protein 1-like | -2.11762 |
| SRP9 | signal recognition particle 9kDa | -2.1162 |
| TKT | transketolase | -2.08952 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.08827 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.08115 |
| EPYC | epiphycan | -2.07965 |
| CCL11 | chemokine (C-C motif) ligand 11 | -2.07365 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -2.06625 |
| CLEC7A | C-type lectin domain family 7, member A | -2.02305 |
