CRCGN008_HEPG2_24H:K16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN008_HEPG2_24H:K16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 6.93045
E2F2 E2F transcription factor 2 5.8172
CHMP6 charged multivesicular body protein 6 5.41595
HLA-DMA major histocompatibility complex, class II, DM alpha 5.33725
PRKCD protein kinase C, delta 5.27895
DYNLT3 dynein, light chain, Tctex-type 3 5.04005
MEST mesoderm specific transcript 5.00835
CCL2 chemokine (C-C motif) ligand 2 4.86705
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.54565
CDPF1 cysteine-rich, DPF motif domain containing 1 4.54285
CNPY3 canopy FGF signaling regulator 3 4.49915
GPER1 G protein-coupled estrogen receptor 1 3.94618
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.5244
GADD45A growth arrest and DNA-damage-inducible, alpha 3.4194
DENND2D DENN/MADD domain containing 2D 3.30665
LPAR2 lysophosphatidic acid receptor 2 3.2675
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.08495
BAMBI BMP and activin membrane-bound inhibitor 2.81845
KIF20A kinesin family member 20A 2.6571
CDK19 cyclin-dependent kinase 19 2.63945
SSBP2 single-stranded DNA binding protein 2 2.6251
NME7 NME/NM23 family member 7 2.57535
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.57473
FOS FBJ murine osteosarcoma viral oncogene homolog 2.5228
JADE2 jade family PHD finger 2 2.50132
RNFT2 ring finger protein, transmembrane 2 2.48785
TXNL4B thioredoxin-like 4B 2.41165
CYCS cytochrome c, somatic 2.3382
KLHL9 kelch-like family member 9 2.3316
PARP12 poly (ADP-ribose) polymerase family, member 12 2.2535
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.24325
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.18057
TBP TATA box binding protein 2.1476
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.1414
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.1354
METRN meteorin, glial cell differentiation regulator 2.1087
OLA1 Obg-like ATPase 1 2.09005
BPHL biphenyl hydrolase-like (serine hydrolase) 2.0445
STXBP2 syntaxin binding protein 2 2.0241
SMYD3 SET and MYND domain containing 3 2.0153
CCP110 centriolar coiled coil protein 110kDa 2.0118

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -5.13055
NUP85 nucleoporin 85kDa -5.0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.6202
MRPS2 mitochondrial ribosomal protein S2 -4.46475
TLCD3A TLC domain containing 3A -4.3038
FASTKD5 FAST kinase domains 5 -4.08145
FGFR4 fibroblast growth factor receptor 4 -4.04583
RNF167 ring finger protein 167 -2.94345
LGMN legumain -2.9048
HSPA8 heat shock 70kDa protein 8 -2.83777
FHL2 four and a half LIM domains 2 -2.8161
SESN1 sestrin 1 -2.81415
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.8068
CCNB1 cyclin B1 -2.75155
MACF1 microtubule-actin crosslinking factor 1 -2.60941
NRIP1 nuclear receptor interacting protein 1 -2.5498
MRPS7 mitochondrial ribosomal protein S7 -2.4385
OXA1L oxidase (cytochrome c) assembly 1-like -2.4286
FEM1C fem-1 homolog c (C. elegans) -2.3976
KCTD2 potassium channel tetramerization domain containing 2 -2.31813
CDR2L cerebellar degeneration-related protein 2-like -2.29045
SYNDIG1 synapse differentiation inducing 1 -2.2788
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.21942
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.1685
IREB2 iron-responsive element binding protein 2 -2.1308
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -2.121
SREK1IP1 SREK1-interacting protein 1 -2.10205
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.091
ITGAV integrin, alpha V -2.09085
CLIC4 chloride intracellular channel 4 -2.07448
CRYBG3 beta-gamma crystallin domain containing 3 -2.00865
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -2.00725