CRCGN008_HEPG2_24H:K17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN008_HEPG2_24H:K17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.37325
CARMIL1 capping protein regulator and myosin 1 linker 1 5.3721
UBQLN2 ubiquilin 2 5.22505
CIAO3 cytosolic iron-sulfur assembly component 3 5.1368
CBR3 carbonyl reductase 3 5.06375
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.86765
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.8568
MAMLD1 mastermind-like domain containing 1 4.6243
GSTZ1 glutathione S-transferase zeta 1 4.1677
VGLL4 vestigial-like family member 4 4.01443
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.9957
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.64588
BAD BCL2-associated agonist of cell death 3.53285
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.45103
GPER1 G protein-coupled estrogen receptor 1 3.32162
RRAGA Ras-related GTP binding A 3.21345
CHN1 chimerin 1 3.16675
CDCA4 cell division cycle associated 4 3.0627
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.91587
RPA3 replication protein A3, 14kDa 2.6384
TBP TATA box binding protein 2.6194
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.52367
CASP8AP2 caspase 8 associated protein 2 2.46915
GARRE1 granule associated Rac and RHOG effector 1 2.42725
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 2.36635
ATAD2 ATPase family, AAA domain containing 2 2.31155
MRPS33 mitochondrial ribosomal protein S33 2.30155
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.27443
TSPYL4 TSPY-like 4 2.24675
EPCIP exosomal polycystin 1 interacting protein 2.14775
BAG3 BCL2-associated athanogene 3 2.1185
NOSIP nitric oxide synthase interacting protein 2.07275
DOK5 docking protein 5 2.0354
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 2.0247
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 2.00955
LOC122526780 uncharacterized LOC122526780 2.00825
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.0041
ECI1 enoyl-CoA delta isomerase 1 2.0038
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 2.0027

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -9.16305
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.2776
CD320 CD320 molecule -5.3594
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -5.3522
CCNB2 cyclin B2 -4.8252
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.79695
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7953
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.8194
CCNB1 cyclin B1 -3.72905
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.573
SOAT2 sterol O-acyltransferase 2 -2.6801
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.5528
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.5223
CHIC2 cysteine-rich hydrophobic domain 2 -2.42965
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.4162
RNF167 ring finger protein 167 -2.3411
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 -2.3113
TSKU tsukushi, small leucine rich proteoglycan -2.14145
ACKR1 atypical chemokine receptor 1 (Duffy blood group) -2.0982
GATAD2A GATA zinc finger domain containing 2A -2.085
TMEM131 transmembrane protein 131 -2.0691
CIC capicua transcriptional repressor -2.0582
RNF19B ring finger protein 19B -2.017