| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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76 genes differentially expressed following the CRCGN008_HEPG2_24H:K18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 5.3278 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 5.2688 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.23275 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 5.23055 |
| PRKCD | protein kinase C, delta | 5.2202 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 5.0968 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 5.0713 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.01705 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 4.92135 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.9053 |
| RPL39L | ribosomal protein L39-like | 4.72345 |
| GSTZ1 | glutathione S-transferase zeta 1 | 4.6791 |
| CNPY3 | canopy FGF signaling regulator 3 | 4.40165 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 4.2774 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 4.18729 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 4.09775 |
| HDGFL3 | HDGF like 3 | 4.05288 |
| ARL4C | ADP-ribosylation factor-like 4C | 3.9223 |
| VGLL4 | vestigial-like family member 4 | 2.98272 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.97585 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.84258 |
| TENT2 | terminal nucleotidyltransferase 2 | 2.67905 |
| CCNF | cyclin F | 2.6553 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | 2.4434 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.4071 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.3818 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 2.3296 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.289 |
| COPS7A | COP9 signalosome subunit 7A | 2.2171 |
| HEBP1 | heme binding protein 1 | 2.1544 |
| TXNL4B | thioredoxin-like 4B | 2.0897 |
| TBCB | tubulin folding cofactor B | 2.0458 |
| GUK1 | guanylate kinase 1 | 2.0376 |
| NEK1 | NIMA-related kinase 1 | 2.02223 |
| MFSD1 | major facilitator superfamily domain containing 1 | 2.01365 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 2.0087 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OXA1L | oxidase (cytochrome c) assembly 1-like | -5.57585 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -5.31625 |
| KDM3A | lysine (K)-specific demethylase 3A | -5.2263 |
| CD320 | CD320 molecule | -4.8967 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -4.85895 |
| ADI1 | acireductone dioxygenase 1 | -4.84645 |
| TUBB6 | tubulin, beta 6 class V | -4.6862 |
| LDHD | lactate dehydrogenase D | -4.4867 |
| TLCD3A | TLC domain containing 3A | -4.1231 |
| CCNB2 | cyclin B2 | -3.86975 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -3.60372 |
| HSPA8 | heat shock 70kDa protein 8 | -3.00167 |
| RGS2 | regulator of G-protein signaling 2 | -2.80215 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.7036 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.64225 |
| RPS5 | ribosomal protein S5 | -2.56605 |
| PHOSPHO2-KLHL23 | PHOSPHO2-KLHL23 readthrough | -2.50905 |
| PRPF4 | pre-mRNA processing factor 4 | -2.45222 |
| CAPRIN1 | cell cycle associated protein 1 | -2.39188 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -2.37523 |
| SLC41A3 | solute carrier family 41, member 3 | -2.28795 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | -2.27915 |
| F2R | coagulation factor II (thrombin) receptor | -2.25785 |
| TRIM36 | tripartite motif containing 36 | -2.2498 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | -2.2005 |
| TMEM259 | transmembrane protein 259 | -2.19907 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | -2.1839 |
| PDE11A | phosphodiesterase 11A | -2.1578 |
| LGALS14 | lectin, galactoside-binding, soluble, 14 | -2.13315 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | -2.11565 |
| CLTB | clathrin, light chain B | -2.11413 |
| DCN | decorin | -2.103 |
| BSG | basigin (Ok blood group) | -2.0971 |
| AZIN2 | antizyme inhibitor 2 | -2.0971 |
| NPY1R | neuropeptide Y receptor Y1 | -2.06165 |
| RGS5 | regulator of G-protein signaling 5 | -2.0307 |
| FHL2 | four and a half LIM domains 2 | -2.026 |
| TXNDC9 | thioredoxin domain containing 9 | -2.00795 |
| ZNF253 | zinc finger protein 253 | -2.0066 |
| OCRL | oculocerebrorenal syndrome of Lowe | -2.0046 |
