CRCGN008_HEPG2_24H:K22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description clofibrate 2.72 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

136 genes differentially expressed following the CRCGN008_HEPG2_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
MAMLD1 mastermind-like domain containing 1 5.59455
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 5.1216
HLA-DMA major histocompatibility complex, class II, DM alpha 5.066
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.86825
E2F2 E2F transcription factor 2 4.7716
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.7383
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.7144
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.50203
LOC122526780 uncharacterized LOC122526780 4.3027
CBR3 carbonyl reductase 3 4.253
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.99995
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.93067
CCL2 chemokine (C-C motif) ligand 2 3.91345
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.7624
EGF epidermal growth factor 3.74795
VGLL4 vestigial-like family member 4 3.19222
CYCS cytochrome c, somatic 3.17185
TIAM1 T-cell lymphoma invasion and metastasis 1 3.07627
ZNF589 zinc finger protein 589 2.90388
PLSCR1 phospholipid scramblase 1 2.73295
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.6745
MAP7 microtubule-associated protein 7 2.659
GSTZ1 glutathione S-transferase zeta 1 2.64555
GOLGA6B golgin A6 family, member B 2.6422
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.61018
CRYGB crystallin, gamma B 2.58995
OR1G1 olfactory receptor, family 1, subfamily G, member 1 2.5492
IL22 interleukin 22 2.5465
PIH1D1 PIH1 domain containing 1 2.5382
ZNF26 zinc finger protein 26 2.51755
ERCC4 excision repair cross-complementation group 4 2.46905
TEX15 testis expressed 15 2.4548
MUC16 mucin 16, cell surface associated 2.41905
ART3 ADP-ribosyltransferase 3 2.4182
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.40285
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.38775
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.3864
PCDHGA10 protocadherin gamma subfamily A, 10 2.3604
FOXO3 forkhead box O3 2.33985
TRADD TNFRSF1A-associated via death domain 2.32975
LGALS13 lectin, galactoside-binding, soluble, 13 2.3234
RSAD2 radical S-adenosyl methionine domain containing 2 2.3222
CNTN1 contactin 1 2.3145
PLSCR3 phospholipid scramblase 3 2.31105
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.27935
CZIB CXXC motif containing zinc binding protein 2.2732
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 2.25925
ASB7 ankyrin repeat and SOCS box containing 7 2.25835
RTP4 receptor (chemosensory) transporter protein 4 2.2389
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.23577
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.2346
CDON cell adhesion associated, oncogene regulated 2.23395
KLHL11 kelch-like family member 11 2.22595
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.2171
BMP3 bone morphogenetic protein 3 2.21455
SPTA1 spectrin, alpha, erythrocytic 1 2.206
CRISP2 cysteine-rich secretory protein 2 2.1887
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.1879
CEP41 centrosomal protein 41kDa 2.18235
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.1804
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.17475
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.171
HSPA1L heat shock 70kDa protein 1-like 2.1629
MCHR1 melanin-concentrating hormone receptor 1 2.16285
LIMD1 LIM domains containing 1 2.15855
MX1 MX dynamin-like GTPase 1 2.1549
USP2 ubiquitin specific peptidase 2 2.15325
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.1501
KLF1 Kruppel-like factor 1 (erythroid) 2.1467
ZNF552 zinc finger protein 552 2.14235
KEL Kell blood group, metallo-endopeptidase 2.14
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.13145
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.1231
VPS50 VPS50 subunit of EARP/GARPII complex 2.1227
SMAD3 SMAD family member 3 2.11605
ZNF507 zinc finger protein 507 2.1147
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.0963
ACTN2 actinin, alpha 2 2.08901
ZBBX zinc finger, B-box domain containing 2.089
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.0857
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 2.08335
TESPA1 thymocyte expressed, positive selection associated 1 2.08175
IL12A interleukin 12A 2.08135
RIGI RNA sensor RIG-I 2.07965
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.07188
IFI44L interferon-induced protein 44-like 2.0714
RNPS1 RNA binding protein S1, serine-rich domain 2.06783
SMIM41 small integral membrane protein 41 2.05975
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.05795
BTG4 B-cell translocation gene 4 2.05415
WNT2 wingless-type MMTV integration site family member 2 2.0479
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.0443
GYPB glycophorin B (MNS blood group) 2.03208
HLA-DMB major histocompatibility complex, class II, DM beta 2.02905
ADAM21 ADAM metallopeptidase domain 21 2.0231
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.02256
MMP26 matrix metallopeptidase 26 2.02245
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 2.01855
DUSP13A dual specificity phosphatase 13A 2.01555
CFAP44 cilia and flagella associated protein 44 2.0132
WWC1 WW and C2 domain containing 1 2.0105

decreased expression

Symbol Name Standardized Value
NRIP1 nuclear receptor interacting protein 1 -5.12092
CD320 CD320 molecule -5.02105
C2CD5 C2 calcium-dependent domain containing 5 -4.9089
ZMIZ1 zinc finger, MIZ-type containing 1 -4.6752
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.61585
RPS5 ribosomal protein S5 -4.51675
RGS2 regulator of G-protein signaling 2 -4.3939
RHEB Ras homolog enriched in brain -3.6971
VDAC1 voltage-dependent anion channel 1 -3.00085
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.99915
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.88393
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.8502
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.77382
OXA1L oxidase (cytochrome c) assembly 1-like -2.67405
CDC25B cell division cycle 25B -2.63985
FOS FBJ murine osteosarcoma viral oncogene homolog -2.63185
RNF167 ring finger protein 167 -2.4207
SAMD14 sterile alpha motif domain containing 14 -2.38365
RHOB ras homolog family member B -2.33065
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.2647
RPL11 ribosomal protein L11 -2.21975
MTOR mechanistic target of rapamycin (serine/threonine kinase) -2.2036
SOAT2 sterol O-acyltransferase 2 -2.17842
ITGB1BP1 integrin beta 1 binding protein 1 -2.1638
NVL nuclear VCP-like -2.157
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -2.11785
CCL24 chemokine (C-C motif) ligand 24 -2.0943
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.08965
SMG5 SMG5 nonsense mediated mRNA decay factor -2.07517
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.06805
DUSP14 dual specificity phosphatase 14 -2.0597
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.02985
RAP1GAP RAP1 GTPase activating protein -2.02335
CDH22 cadherin 22, type 2 -2.0188