CRCGN008_HEPG2_24H:K23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description clofibrate 1.36 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN008_HEPG2_24H:K23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.4615
CXCL2 chemokine (C-X-C motif) ligand 2 5.2962
STIMATE STIM activating enhancer 4.98495
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.9259
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.9022
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.3431
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.32045
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.1598
NOSIP nitric oxide synthase interacting protein 3.8706
RPP38 ribonuclease P/MRP 38kDa subunit 3.85585
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.78767
CDPF1 cysteine-rich, DPF motif domain containing 1 3.77505
GPER1 G protein-coupled estrogen receptor 1 3.61542
CD40 CD40 molecule, TNF receptor superfamily member 5 3.56363
H2BC12 H2B clustered histone 12 3.32925
TIAM1 T-cell lymphoma invasion and metastasis 1 3.30927
KIF5C kinesin family member 5C 3.09107
MAP7 microtubule-associated protein 7 3.00085
HEBP1 heme binding protein 1 2.91325
HLA-DRA major histocompatibility complex, class II, DR alpha 2.87963
CHN1 chimerin 1 2.7399
NPDC1 neural proliferation, differentiation and control, 1 2.3506
TRIM13 tripartite motif containing 13 2.31645
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.20875
AXIN1 axin 1 2.1363
CRTAP cartilage associated protein 2.0254
ALLC allantoicase 2.00525

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -10.0
ENOPH1 enolase-phosphatase 1 -5.1794
TLCD3A TLC domain containing 3A -4.8527
HLA-DMA major histocompatibility complex, class II, DM alpha -3.53195
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.36737
CLTB clathrin, light chain B -3.34203
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.2981
ZMIZ1 zinc finger, MIZ-type containing 1 -3.0169
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.6396
FOS FBJ murine osteosarcoma viral oncogene homolog -2.3835
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.30315
PGM1 phosphoglucomutase 1 -2.1943
HSPA8 heat shock 70kDa protein 8 -2.15513
BBS7 Bardet-Biedl syndrome 7 -2.15275
ANKRD17 ankyrin repeat domain 17 -2.14585
RIC8B RIC8 guanine nucleotide exchange factor B -2.1019
ZW10 zw10 kinetochore protein -2.07225