CRCGN008_HEPG2_24H:K24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description clofibrate 0.68 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

117 genes differentially expressed following the CRCGN008_HEPG2_24H:K24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
CHN1 chimerin 1 7.1847
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.4753
MOK MOK protein kinase 5.1923
PPARG peroxisome proliferator-activated receptor gamma 5.15675
MINDY1 MINDY lysine 48 deubiquitinase 1 5.12955
ANO1 anoctamin 1, calcium activated chloride channel 5.0
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.885
GSTZ1 glutathione S-transferase zeta 1 4.8703
STK10 serine/threonine kinase 10 4.77327
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.77075
PNKP polynucleotide kinase 3'-phosphatase 4.727
CIAO3 cytosolic iron-sulfur assembly component 3 4.51135
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.2736
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.15182
GPER1 G protein-coupled estrogen receptor 1 3.92645
HLA-DRA major histocompatibility complex, class II, DR alpha 3.76455
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.53673
GATA3 GATA binding protein 3 3.39322
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.3388
PRKCH protein kinase C, eta 3.25513
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.17455
SLC75A1 solute carrier family 75 member 1 3.10095
E2F2 E2F transcription factor 2 3.0576
JADE2 jade family PHD finger 2 2.93187
EPHA3 EPH receptor A3 2.74672
DEFB126 defensin, beta 126 2.7333
SSBP2 single-stranded DNA binding protein 2 2.7239
ZFYVE21 zinc finger, FYVE domain containing 21 2.63665
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.62713
LOC122526780 uncharacterized LOC122526780 2.61015
PLSCR3 phospholipid scramblase 3 2.49207
CBFB core-binding factor, beta subunit 2.44023
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.4192
HACD1 3-hydroxyacyl-CoA dehydratase 1 2.4117
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.40038
CETP cholesteryl ester transfer protein, plasma 2.3831
EGLN1 egl-9 family hypoxia-inducible factor 1 2.3588
DAND5 DAN domain family member 5, BMP antagonist 2.3214
GUK1 guanylate kinase 1 2.30215
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.29743
MCRS1 microspherule protein 1 2.2784
SCRN1 secernin 1 2.2671
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.2593
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.25045
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 2.24385
FTSJ3 FtsJ homolog 3 (E. coli) 2.21955
KANSL3 KAT8 regulatory NSL complex subunit 3 2.19775
DISC1 disrupted in schizophrenia 1 2.19605
NDE1 nudE neurodevelopment protein 1 2.1938
DRAM1 DNA-damage regulated autophagy modulator 1 2.19375
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.1733
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.17145
DOCK2 dedicator of cytokinesis 2 2.16345
ARL2BP ADP-ribosylation factor-like 2 binding protein 2.15705
FABP4 fatty acid binding protein 4, adipocyte 2.15655
TXNL4B thioredoxin-like 4B 2.1454
RRAGA Ras-related GTP binding A 2.13615
SSTR4 somatostatin receptor 4 2.1333
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.12083
LRRC15 leucine rich repeat containing 15 2.10955
COL8A1 collagen, type VIII, alpha 1 2.10643
BFSP2 beaded filament structural protein 2, phakinin 2.0945
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 2.09203
GRK4 G protein-coupled receptor kinase 4 2.08823
MIS18BP1 MIS18 binding protein 1 2.0844
NIT2 nitrilase family, member 2 2.07495
SH2D1A SH2 domain containing 1A 2.06942
HAUS7 HAUS augmin-like complex, subunit 7 2.06658
HOXC5 homeobox C5 2.06515
FBN1 fibrillin 1 2.06507
SSUH2 ssu-2 homolog (C. elegans) 2.04385
NRBF2 nuclear receptor binding factor 2 2.04095
MCF2 MCF.2 cell line derived transforming sequence 2.04045
KRT34 keratin 34, type I 2.0383
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.03465
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.02885
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like 2.0232
VILL villin-like 2.0171
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.0139
TXNIP thioredoxin interacting protein 2.00997
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.00752
ELSPBP1 epididymal sperm binding protein 1 2.0069
STK32B serine/threonine kinase 32B 2.00625
PTOV1 prostate tumor overexpressed 1 2.00615
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.0019
IFFO1 intermediate filament family orphan 1 2.00002

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -6.8481
OXA1L oxidase (cytochrome c) assembly 1-like -5.87855
SMNDC1 survival motor neuron domain containing 1 -5.6325
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -5.00455
LDHD lactate dehydrogenase D -5.0035
C2CD5 C2 calcium-dependent domain containing 5 -4.788
HSPB1 heat shock 27kDa protein 1 -4.71125
FASTKD5 FAST kinase domains 5 -4.412
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.40257
RNF167 ring finger protein 167 -3.0282
FBXL12 F-box and leucine-rich repeat protein 12 -2.863
NRIP1 nuclear receptor interacting protein 1 -2.72828
TUBA4A tubulin, alpha 4a -2.68025
SETBP1 SET binding protein 1 -2.5682
CFAP298 cilia and flagella associated protein 298 -2.40505
PPL periplakin -2.3595
PUM1 pumilio RNA-binding family member 1 -2.351
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -2.30425
MAP2K5 mitogen-activated protein kinase kinase 5 -2.28807
CEP70 centrosomal protein 70kDa -2.2439
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -2.21955
EFNA3 ephrin-A3 -2.21935
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.15345
IRF8 interferon regulatory factor 8 -2.1022
PHC1 polyhomeotic homolog 1 (Drosophila) -2.0966
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.09295
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -2.0908
SNRPC small nuclear ribonucleoprotein polypeptide C -2.0792
PTBP2 polypyrimidine tract binding protein 2 -2.07355
APOE apolipoprotein E -2.05372