CRCGN008_HEPG2_24H:L05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl methacrylate 2.44 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN008_HEPG2_24H:L05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
JADE2 jade family PHD finger 2 5.82718
CARMIL1 capping protein regulator and myosin 1 linker 1 5.12035
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9813
CIAO3 cytosolic iron-sulfur assembly component 3 4.908
CHMP6 charged multivesicular body protein 6 4.90205
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.79255
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.78195
SNAP25 synaptosomal-associated protein, 25kDa 4.50968
EPHA3 EPH receptor A3 4.43592
GSTZ1 glutathione S-transferase zeta 1 4.35405
SSBP2 single-stranded DNA binding protein 2 4.05113
PRR15L proline rich 15-like 3.90125
PEX11A peroxisomal biogenesis factor 11 alpha 3.78298
CNPY3 canopy FGF signaling regulator 3 3.59205
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.59123
LOC122526780 uncharacterized LOC122526780 3.5898
GPER1 G protein-coupled estrogen receptor 1 3.57565
CYCS cytochrome c, somatic 3.38495
NOSIP nitric oxide synthase interacting protein 3.3455
TIAM1 T-cell lymphoma invasion and metastasis 1 3.30483
VGLL4 vestigial-like family member 4 3.10075
CHN1 chimerin 1 3.00475
MAP7 microtubule-associated protein 7 2.45767
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.43567
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.41065
SLC35A5 solute carrier family 35, member A5 2.37075
TNIP1 TNFAIP3 interacting protein 1 2.34635
FOS FBJ murine osteosarcoma viral oncogene homolog 2.31485
LPAR2 lysophosphatidic acid receptor 2 2.28408
MRPL58 mitochondrial ribosomal protein L58 2.2103
FAM200C family with sequence similarity 200 member C 2.2045
BPHL biphenyl hydrolase-like (serine hydrolase) 2.19925
CERS6 ceramide synthase 6 2.1302
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.09065
AHCY adenosylhomocysteinase 2.03985
CDCA4 cell division cycle associated 4 2.01715
LGI1 leucine-rich, glioma inactivated 1 2.00525

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.0152
CCNB2 cyclin B2 -4.93515
LDHD lactate dehydrogenase D -4.68295
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.64115
SLC35F2 solute carrier family 35, member F2 -4.32425
FGFR4 fibroblast growth factor receptor 4 -3.85042
RGS2 regulator of G-protein signaling 2 -3.13355
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.02195
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.0013
OXA1L oxidase (cytochrome c) assembly 1-like -2.7793
FHL2 four and a half LIM domains 2 -2.75885
SPAG4 sperm associated antigen 4 -2.68055
NKG7 natural killer cell granule protein 7 -2.6404
CTSW cathepsin W -2.2914
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.25235
HSPA8 heat shock 70kDa protein 8 -2.23168
MYH6 myosin, heavy chain 6, cardiac muscle, alpha -2.22132
TNNT1 troponin T type 1 (skeletal, slow) -2.20635
FGF21 fibroblast growth factor 21 -2.2025
FBXL12 F-box and leucine-rich repeat protein 12 -2.172
MYH7 myosin, heavy chain 7, cardiac muscle, beta -2.08225
TNNT3 troponin T type 3 (skeletal, fast) -2.04705
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.0138
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.0079