CRCGN008_HEPG2_24H:L06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl methacrylate 1.22 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN008_HEPG2_24H:L06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 5.62485
UBQLN2 ubiquilin 2 5.5658
RPP38 ribonuclease P/MRP 38kDa subunit 5.2983
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.19715
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.60675
CHN1 chimerin 1 4.40015
SSBP2 single-stranded DNA binding protein 2 4.13485
PRR15L proline rich 15-like 4.111
ALDOC aldolase C, fructose-bisphosphate 3.9948
GPER1 G protein-coupled estrogen receptor 1 3.97177
GARRE1 granule associated Rac and RHOG effector 1 3.70405
VGLL4 vestigial-like family member 4 3.62608
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.38503
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.35105
GATA3 GATA binding protein 3 3.22527
HEBP1 heme binding protein 1 2.88335
GPATCH8 G patch domain containing 8 2.79885
TBP TATA box binding protein 2.7582
LMBRD1 LMBR1 domain containing 1 2.68185
SCYL3 SCY1-like 3 (S. cerevisiae) 2.61627
CCNF cyclin F 2.37818
ICAM1 intercellular adhesion molecule 1 2.31703
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.22935
MAGEH1 melanoma antigen family H1 2.22035
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.19055
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.1331
TCIM transcriptional and immune response regulator 2.0688
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.02865
MKRN2 makorin ring finger protein 2 2.0037

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -10.0
LDHD lactate dehydrogenase D -10.0
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.9743
CDC25B cell division cycle 25B -4.65345
NT5DC2 5'-nucleotidase domain containing 2 -4.5989
TUBB6 tubulin, beta 6 class V -4.2697
TLCD3A TLC domain containing 3A -3.7063
RFC2 replication factor C (activator 1) 2, 40kDa -3.56887
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.41225
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.25227
ZMIZ1 zinc finger, MIZ-type containing 1 -3.22555
HSPA8 heat shock 70kDa protein 8 -3.14047
HMG20B high mobility group 20B -3.08795
OXA1L oxidase (cytochrome c) assembly 1-like -3.0622
WASHC4 WASH complex subunit 4 -2.88893
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.51465
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.392
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.23395
RSU1 Ras suppressor protein 1 -2.22355
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.18867
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.1756
TXNRD1 thioredoxin reductase 1 -2.1502
TATDN2 TatD DNase domain containing 2 -2.14435
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.10675
OGDHL oxoglutarate dehydrogenase-like -2.1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.0774
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.0712
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.06805
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.05105
IL17B interleukin 17B -2.0359